Return-Path: Received: from [2607:fb90:e281:43e1::f0:ffff] ([2607:fb90:e281:43e1:146c:3fce:4f9e:3910]) by smtp.gmail.com with ESMTPSA id 00721157ae682-79a905ba0a9sm79498237b3.46.2026.03.24.15.19.39 for (version=TLS1_2 cipher=ECDHE-ECDSA-AES128-GCM-SHA256 bits=128/128); Tue, 24 Mar 2026 15:19:40 -0700 (PDT) Date: Tue, 24 Mar 2026 18:19:34 -0400 From: tjphuhs@gmail.com To: "=?utf-8?Q?oc.tjphuhs=40gmail.com?=" Message-ID: In-Reply-To: <20260324.220458.1556dce8@mta13> References: <20260324.220458.1556dce8@mta13> Subject: Fwd: Dihexa Deep Dive X-Readdle-Message-ID: a1657de7-3360-4585-9560-59dd60d5ba42@Spark MIME-Version: 1.0 Content-Type: multipart/alternative; boundary="69c30dfa_2fa02401_4efb" --69c30dfa_2fa02401_4efb Content-Type: text/plain; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Disposition: inline ---------- =46orwarded message ---------- =46rom: Hunter Williams Date: Mar 24, 2026 at 6:05=E2=80=AFPM -0400 To: tjphuhs=40gmail.com Subject: Dihexa Deep Dive > New video is live=21 > March 24, 2026 =C2=A0 =7C =C2=A0 Read online > Dihexa Deep Dive > New video is live=21 > > > > Happy Tuesday=21 > I just dropped a brand new deep dive video over on Spotify. This one is= all about Dihexa. > > Dihexa Deep Dive =7C Dosing, Safety, and Why I Keep Coming Back to It > The Hunter Williams Podcast =C2=B7 Episode > open.spotify.com/episode/1AgU8pUfumBRW3W5UiYpnu=3Fsi=3Dk8U0UKEYR9Wwevbs= h5cSTg > > I genuinely think Dihexa is one of the most underappreciated compounds = in the cognitive enhancement space right now. > If you've been following me for a while, you know I'm not really a noot= ropics guy. > When you're hormonally optimized and running peptides, you get a lot of= cognitive function as a byproduct. I don't need to push the gas pedal to= o often. > But Dihexa is different. > It sits in this perfect middle ground for me. Strong enough that I actu= ally feel it working. Not so strong that I lose my personality or start f= eeling like a robot. I like operating as a human being with empathy and s= ocial awareness, and some nootropics can strip that away. > In today=E2=80=99s email, I will break down what I covered in the video= . > > Dihexa > Dihexa is a synthetic peptide developed over two decades at Washington = State University. It was derived from angiotensin IV. > What makes it special is that it promotes synaptogenesis, meaning it he= lps your brain form brand new synaptic connections between neurons. > > How It Works in the Brain > Dihexa binds to hepatocyte growth factor (HG=46). That binding helps HG= =46 dimerize. Once that happens, it activates the c-Met receptor tyrosine= kinase on the surface of your neurons. This initiates downstream signali= ng via the PI3K/AKT pathway and the MAPK/ERK cascade. > The end result is synaptogenesis. > New synaptic connections form in your hippocampus and other brain regio= ns responsible for learning and memory. > It also crosses the blood-brain barrier when taken orally. Most neurotr= ophic factors can't do that. Dihexa can, thanks to its engineered lipophi= licity and small molecular size. > One more interesting detail. The half-life is around 12 to 13 days. Tha= t's extraordinarily long. It means you get a cumulative effect when dosin= g regularly. It also means you probably don't need to take it every singl= e day. > > Studies > A 2021 study out of China Pharmaceutical University confirmed that oral= Dihexa improved spatial learning in APP/PS1 mice. > It increased neuronal cell counts, elevated synaptophysin expression, a= nd reduced neuroinflammation. Specifically, it decreased IL-1=CE=B2 and T= N=46-=CE=B1 while increasing the anti-inflammatory cytokine IL-10. > Then there's a 2025 study from Rowan University. Dihexa dose-dependentl= y improved working memory after repeated mild traumatic brain injury. > As someone who played football and has had multiple concussions, the TB= I angle is near and dear to me. This is where I think Dihexa has some rea= l untapped potential. > > Dosing and How I Use It > Let me share what I covered in the video about dosing. Keep in mind thi= s is based on community experience and the underground nootropic space. > Oral capsules are the most common route. The typical range is 5 to 40 m= g. Personally, 10 mg is the sweet spot. At 5 mg, I notice something subtl= e. At 10 mg, I get a solid cognitive bump without being pushed too far. > =46or subcutaneous injection, I'd stay around 1 to 3 mg 2-3 times per w= eek. Injection is 100% bioavailable, compared with roughly 38% for oral a= dministration. > I like to take the oral capsules three times per week, or sometimes jus= t on days when I know I need to be locked in for deep work. > Given the long half-life, you really don't need daily dosing. Two to th= ree times per week gives you solid benefit without unnecessary accumulati= on. > =46or cycling, I recommend 8 to 12 weeks on, then two to four weeks off= . And on your off days, consider taking alpha-GPC to help replenish neuro= transmitters. That's a great support compound for any nootropic protocol.= > > =46inal Thoughts > Here's my honest take on Dihexa. > Every time I take it, I get a noticeable effect. The cognitive clarity = and focus are tangible. Not overwhelming. Not personality-altering. Just = a clean bump in processing power when I need it. > Will we ever have extensive clinical data on Dihexa itself=3F Probably = not. No pharmaceutical company is going to invest hundreds of millions to= take a simple peptide through =46DA approval when they can't patent it. = The economics don't work. > =46or age-related cognitive decline, I think Dihexa could be genuinely = helpful. =46or TBI recovery, I'd absolutely include it alongside Cerebrol= ysin, BPC-157, and TB-500. > =46or healthy folks who want a cognitive edge without the heavy push of= something like Modafinil, it's a great fit. > Start low. Work your way up. Cycle responsibly. Don't be the person who= jumps to 40 mg a day because someone on the internet told you to. > Thank you for your support of my work=21 > Best, > Hunter Williams > P.S. You can get Dihexa from the following places: > > =E2=80=A2 > BioLongevity Labs code HUNTERW (it=E2=80=99s an ingredient = in BioMind alongside Noopept and J-147) > =E2=80=A2 > Parabolic Peptides code TAYLORW (just pure dihexa) > > > =46urther Reading > > =E2=80=A2 > https://pubmed.ncbi.nlm.nih.gov/34827486/ > =E2=80=A2 > https://www.liebertpub.com/doi/full/10.1177/2689288X2513928= 51 > > Want more=3F Here=E2=80=99s how you can work with me: > =F0=9F=91=89Join my private coaching group, The AXION Collective: > > =E2=80=A2 > The AXION Collective > > =F0=9F=91=89Try Zeroats, the world=E2=80=99s first sugar-free, naturall= y flavored oatmeal: > > =E2=80=A2 > Store:=C2=A0https://zeroats.com/ > =E2=80=A2 > Amazon:=C2=A0https://a.co/d/2gq1zJ9 > > =F0=9F=91=89Link To All My Old Videos: > > =E2=80=A2 > DropBox with all videos > > =F0=9F=91=89Audio Versions of All Videos: > > =E2=80=A2 > Itunes > =E2=80=A2 > Spotify > > =F0=9F=91=89Get the Peptide Cheat Sheet: > > =E2=80=A2 > Peptide Cheat Sheet > > =F0=9F=91=89All my daily essentials on Amazon > > =E2=80=A2 > Amazon Storefront > > =F0=9F=91=89Get discounts on your favorite peptides and research chemic= als: > > =E2=80=A2 > PEPTIDES > =E2=80=A2 > BioLongevity Labs (use code hunterw for 15% off):=C2=A0= https://biolongevitylabs.com/ > > =F0=9F=91=8910% off the BEST workout supplements from Unmatched Supps (= pre-workout, whey protein, creatine, EAAs, electrolytes - use code HUNTER= W at checkout): > > =E2=80=A2 > https://www.unmatchedsupps.com=3Fsca=5Fref=3D8677061.S6mh8S= OsogBzjOO > > =F0=9F=91=89Submit A Video Topic =46or My Next YouTube Video: > > =E2=80=A2 > https://hunterwilliamsvideotopic.carrd.co/ > > Update your email preferences or unsubscribe here > =C2=A9 2026 Hunter's Health Hacks > 228 Park Ave S, =2329976, New York, New York 10003, United States > Powered by beehiiv > Terms of Service --69c30dfa_2fa02401_4efb Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Disposition: inline
---------- =46orwarded message ----= ------
=46rom: Hunter Williams <huntershealthhacks=40mail.beehiiv.com&= gt;
Date: Mar 24, 2026 at 6:05=E2=80=AFPM -0400
To: tjphuhs=40gmail.com <tjphuhs=40gmail.com>
Subject: Dihexa Deep Dive

New video= is live=21 &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C= &=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=231= 60;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2=80=8C&=23160;=E2= =80=8C&=23160;=E2=80=8C

March 24, 2026 &=23160; =7C &=23160; Read online

Dihexa Deep Dive

New video is live=21
3D=22share
&=23160;
3D=22share
&=23160;
3D=22share
&=23160;
3D=22share
3D=22=22

Happy Tuesday=21

I just dropped a brand new deep dive video over on Spotify. Thi= s one is all about Dihexa.
<=21--=5Bif =21mso=5D><=21-->
&=23= 160;
<=21--<=21=5Bendif=5D-->

Dihexa Deep Dive =7C Dosing,= Safety, and Why I Keep Coming Back to It
The Hunter Williams P= odcast =C2=B7 Episode
open.spotify.com/episode/1AgU8pUfumBRW3W5UiYpnu=3Fsi=3Dk8U0UK= EYR9Wwevbsh5cSTg

&=23160;

I genuinely think Dihexa is one of the most underappreciated co= mpounds in the cognitive enhancement space right now.

If you've been following me for a while, you know I'm not reall= y a nootropics guy.

When you're hormonally optimized and running peptides, you get = a lot of cognitive function as a byproduct. I don't need to push the gas = pedal too often.

But Dihexa is different.

It sits in this perfect middle ground for me. Strong enough tha= t I actually feel it working. Not so strong that I lose my personality or= start feeling like a robot. I like operating as a human being with empat= hy and social awareness, and some nootropics can strip that away.<= /p>

In today=E2=80=99s email, I will break down what I covered in t= he video.
&=23160;

Dihexa

Dihexa is a synthetic peptide developed over two decades at Was= hington State University. It was derived from angiotensin IV.

What makes it special is that it promotes synaptogenesis, meani= ng it helps your brain form brand new synaptic connections between neuron= s.
&=23160;

How It Works in the Brain

Dihexa binds to hepatocyte growth factor (HG=46). That binding = helps HG=46 dimerize. Once that happens, it activates the c-Met receptor = tyrosine kinase on the surface of your neurons. This initiates downstream= signaling via the PI3K/AKT pathway and the MAPK/ERK cascade.

The end result is synaptogenesis.

New synaptic connections form in your hippocampus and other bra= in regions responsible for learning and memory.

It also crosses the blood-brain barrier when taken orally. Most= neurotrophic factors can't do that. Dihexa can, thanks to its engineered= lipophilicity and small molecular size.

One more interesting detail. The half-life is around 12 to 13 d= ays. That's extraordinarily long. It means you get a cumulative effect wh= en dosing regularly. It also means you probably don't need to take it eve= ry single day.
&=23160;

Studies

A 2021 study out of China Pharmaceutical University confirmed t= hat oral Dihexa improved spatial learning in APP/PS1 mice.

It increased neuronal cell counts, elevated synaptophysin expre= ssion, and reduced neuroinflammation. Specifically, it decreased IL-1=CE=B2= and TN=46-=CE=B1 while increasing the anti-inflammatory cytokine IL-10.<= /span>

Then there's a 2025 study from Rowan University. Dihexa dose-de= pendently improved working memory after repeated mild traumatic brain inj= ury.

As someone who played football and has had multiple concussions= , the TBI angle is near and dear to me. This is where I think Dihexa has = some real untapped potential.
&=23160;

Dosing and How I Use It

Let me share what I covered in the video about dosing. Keep in = mind this is based on community experience and the underground nootropic = space.

Oral capsules are the most common route. The typical range is 5= to 40 mg. Personally, 10 mg is the sweet spot. At 5 mg, I notice somethi= ng subtle. At 10 mg, I get a solid cognitive bump without being pushed to= o far.

=46or subcutaneous injection, I'd stay around 1 to 3 mg 2-3 tim= es per week. Injection is 100% bioavailable, compared with roughly 38% fo= r oral administration.

I like to take the oral capsules three times per week, or somet= imes just on days when I know I need to be locked in for deep work.

Given the long half-life, you really don't need daily dosing. T= wo to three times per week gives you solid benefit without unnecessary ac= cumulation.

=46or cycling, I recommend 8 to 12 weeks on, then two to four w= eeks off. And on your off days, consider taking alpha-GPC to help repleni= sh neurotransmitters. That's a great support compound for any nootropic p= rotocol.
&=23160;

=46inal Thoughts

Here's my honest take on Dihexa.

Every time I take it, I get a noticeable effect. The cognitive = clarity and focus are tangible. Not overwhelming. Not personality-alterin= g. Just a clean bump in processing power when I need it.

Will we ever have extensive clinical data on Dihexa itself=3F P= robably not. No pharmaceutical company is going to invest hundreds of mil= lions to take a simple peptide through =46DA approval when they can't pat= ent it. The economics don't work.

=46or age-related cognitive decline, I think Dihexa could be ge= nuinely helpful. =46or TBI recovery, I'd absolutely include it alongside = Cerebrolysin, BPC-157, and TB-500.

=46or healthy folks who want a cognitive edge without the heavy= push of something like Modafinil, it's a great fit.

Start low. Work your way up. Cycle responsibly. Don't be the pe= rson who jumps to 40 mg a day because someone on the internet told you to= .

Thank you for your support of my work=21

Best,

Hunter Williams

P.S. You can get Dihexa from the following places:
&=23160;

=46urther Reading
3D=22ig=22

Want more=3F Here=E2=80=99s= how you can work with me:

=F0=9F=91=89Join my private= coaching group, The AXION Collective:

=F0=9F=91=89Try Zeroats, th= e world=E2=80=99s first sugar-free, naturally flavored oatmeal:

=F0=9F=91=89Get the Peptide= Cheat Sheet:

=F0=9F=91=89All my daily es= sentials on Amazon

=F0=9F=91=89Get discounts o= n your favorite peptides and research chemicals:

  • PEPTIDES<= /p>

=F0=9F=91=8910% off the BES= T workout supplements from Unmatched Supps (pre-workout, whey protein, cr= eatine, EAAs, electrolytes - use code HUNTERW at checkout):

=F0=9F=91=89Submit A Video = Topic =46or My Next YouTube Video:

Update your email preferences or unsubscribe here

=C2=A9 2026 Hunter's Health Hacks

228 Park Ave S, =2329976, New York, New York 10003, United S= tates
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