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[69.67.186.2]) by mx.google.com with ESMTPS id 6a1803df08f44-89c853598b1si240291446d6.453.2026.03.24.15.05.25 for (version=TLS1_3 cipher=TLS_AES_256_GCM_SHA384 bits=256/256); Tue, 24 Mar 2026 15:05:25 -0700 (PDT) Received-SPF: pass (google.com: domain of bounces+tjphuhs=gmail.com@bh.mail.beehiiv.com designates 69.67.186.2 as permitted sender) client-ip=69.67.186.2; Authentication-Results: mx.google.com; dkim=pass header.i=@bhmta.beehiiv.com header.s=bh header.b=2Mbvj71f; dkim=pass header.i=@mail.beehiiv.com header.s=bh header.b="jFY7V/fP"; spf=pass (google.com: domain of bounces+tjphuhs=gmail.com@bh.mail.beehiiv.com designates 69.67.186.2 as permitted sender) smtp.mailfrom="bounces+tjphuhs=gmail.com@bh.mail.beehiiv.com"; dmarc=pass (p=REJECT sp=REJECT dis=NONE) header.from=beehiiv.com X-BmtaRef: eyJfQF8iOiJcXF8vIiwicmVjaXBpZW50IjoidGpwaHVoc0BnbWFpbC5jb20iLCJ4X2xpc3RfaWQiOiJmZDQxNjMwZS1lOTFmLTQ2ZDktYTI3NC1iNzQwZGFiNzU2ZDIiLCJ4X3N1YnNjcmliZXJfaWQiOiI5YzQwZDYzOS02ZTFkLTQyOTItYTlkNy0wZTRjYmJiNWQ1ZGIifQ== DKIM-Signature: v=1; a=rsa-sha256; d=bhmta.beehiiv.com; s=bh; c=relaxed/relaxed; bh=S+3INYgb5yctgdYnylgeI4VDMNyoUSsocT8toO8p5CM=; h=from:subject:mime-version:content-type:content-transfer-encoding: list-unsubcribe:feedback-id:list-unsubscribe-post:reply-to:to:cc: content-type:feedback-id:from:subject:to; t=1774389898; b=2Mbvj71f1O6+ix2GhPJDxCRE+eSOM+vrR2cY7wbujOLvZJ4uflyZFLtc5eZHIaepiLsGfRLP/ hg68yG63bCUURYyyP4hSPH7LN3svDXuwTLtiJA9kZ6BTQ645wViA1u5rnO/O261hRcqe5/S90CA d0JE7k2K3buodzcdG554DaDUsD2cbgyzWGcNq/ql5h7v/Qu3deZwGDHOYlcl+JaEz+p/EqTL7ih pzddwif4Y15TT+YC0h8LCUsioSF7aXTKDWDNazPkDMetjRQDSDVfQ4fG8JX8cpCDCQNy4QduHR/ Zd1E5HYvW3/LGbpFRvAvVDtrAl9x1Fr45Q4nHby3S2EQ==; DKIM-Signature: v=1; a=rsa-sha256; d=mail.beehiiv.com; s=bh; c=relaxed/relaxed; bh=S+3INYgb5yctgdYnylgeI4VDMNyoUSsocT8toO8p5CM=; h=from:subject:mime-version:content-type:content-transfer-encoding: list-unsubcribe:feedback-id:list-unsubscribe-post:reply-to:to:cc: content-type:feedback-id:from:subject:to; t=1774389898; b=jFY7V/fPkWyJ+6r05o4b2sV82qsogL+HW5tI8fj8q+65hY1c4y396/ob5SrNQP4TusJ42jz5R lidE6qTnk98s+iBOuDzVXH+Pc6vNn7gsiHJcg7KeMOPEMK8QNHMsm8uemuRPEneX1uZU+LLIFJO FrCGYQgEi8gqKH+I3gM380glSIsQDe/HRn7CCZhoamfbVEL3+uo0l/uKx95dRKePpmyajeHUkqE YiRyOFtfyvw7p7DlR4sj8zkM+A+CHWDoQAxPFLo3hqgc/rPXbG947r84p4QBvxoNY7BzUQL8nQU zwqeAftktuSQSGWlRQdd1YD/ShaxkaVRmqDqwyHf8F2A==; Received: from mail.beehiiv.com by bhmta(mta13) with HTTP id <7f40ba1727cd11f1b1a61228d4c0508b> for ; Tue, 24 Mar 2026 22:04:58 +0000 Content-Type: multipart/alternative; boundary="BNbOu2hoQIK2VdRZ6vKUsQ" To: "tjphuhs@gmail.com" Feedback-ID: 6a6a56e0-6d99-437d-9e81-db99fc1a9ad5:newsletter:fd41630e-e91f-46d9-a274-b740dab756d2:c8f61fda6a60803 From: Hunter Williams List-Unsubscribe: , List-Unsubscribe-Post: List-Unsubscribe=One-Click Reply-To: =?utf-8?Q?Hunter=27s_Health_Hacks?= Subject: Dihexa Deep Dive X-Batch-Id: 5975d0f0-ee4f-49ea-8dd0-42b6c3503f43 X-Subscriber-ID: 9c40d639-6e1d-4292-a9d7-0e4cbbb5d5db sId: fd41630e-e91f-46d9-a274-b740dab756d2 x-beehiiv-ids: {"account_name":"https://huntershealthhacks.beehiiv.com/","campaign_id":"6a6a56e0-6d99-437d-9e81-db99fc1a9ad5","category":"newsletter","email_generated_at":1774389895,"user_id":"fd41630e-e91f-46d9-a274-b740dab756d2"} x-beehiiv-type: newsletter x-list-id: fd41630e-e91f-46d9-a274-b740dab756d2 x-list-owner: x-newsletter: https://huntershealthhacks.beehiiv.com/p/dihexa-deep-dive x-newsletter-id: https://huntershealthhacks.beehiiv.com/ x-newsletter-signup: https://huntershealthhacks.beehiiv.com/subscribe Mime-Version: 1.0 Date: Tue, 24 Mar 2026 22:04:58 +0000 Message-ID: <20260324.220458.1556dce8@mta13> --BNbOu2hoQIK2VdRZ6vKUsQ Content-Type: text/plain; charset="utf-8" Content-Transfer-Encoding: quoted-printable Happy Tuesday! =0A=0AI just dropped a brand new deep dive video over on Spo= tify. This one is all about Dihexa. =0A=0ADihexa Deep Dive | Dosing, Safety= , and Why I Keep Coming Back to It: (https://open.spotify.com/episode/1AgU8= pUfumBRW3W5UiYpnu?si=3Dk8U0UKEYR9Wwevbsh5cSTg)=0A=0AI genuinely think Dihex= a is one of the most underappreciated compounds in the cognitive enhancemen= t space right now.=0A=0AIf you've been following me for a while, you know I= 'm not really a nootropics guy. =0A=0AWhen you're hormonally optimized and = running peptides, you get a lot of cognitive function as a byproduct. I don= 't need to push the gas pedal too often.=0A=0ABut Dihexa is different.=0A= =0AIt sits in this perfect middle ground for me. Strong enough that I actua= lly feel it working. Not so strong that I lose my personality or start feel= ing like a robot. I like operating as a human being with empathy and social= awareness, and some nootropics can strip that away.=0A=0AIn today=E2=80=99= s email, I will break down what I covered in the video. =0A=0A=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=0A=0A**Dihexa**=0A=0ADihexa is a synthetic peptide developed over tw= o decades at Washington State University. It was derived from angiotensin I= V. =0A=0AWhat makes it special is that it promotes synaptogenesis, meaning = it helps your brain form brand new synaptic connections between neurons.=0A= =0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=0A=0A**How It Works in the Brain**=0A=0ADihexa binds = to hepatocyte growth factor (HGF). That binding helps HGF dimerize. Once th= at happens, it activates the c-Met receptor tyrosine kinase on the surface = of your neurons. This initiates downstream signaling via the PI3K/AKT pathw= ay and the MAPK/ERK cascade.=0A=0AThe end result is synaptogenesis. =0A=0AN= ew synaptic connections form in your hippocampus and other brain regions re= sponsible for learning and memory.=0A=0AIt also crosses the blood-brain bar= rier when taken orally. Most neurotrophic factors can't do that. Dihexa can= , thanks to its engineered lipophilicity and small molecular size.=0A=0AOne= more interesting detail. The half-life is around 12 to 13 days. That's ext= raordinarily long. It means you get a cumulative effect when dosing regular= ly. It also means you probably don't need to take it every single day.=0A= =0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=0A=0A**Studies**=0A=0AA 2021 study out of China Pharm= aceutical University confirmed that oral Dihexa improved spatial learning i= n APP/PS1 mice. =0A=0AIt increased neuronal cell counts, elevated synaptoph= ysin expression, and reduced neuroinflammation. Specifically, it decreased = IL-1=CE=B2 and TNF-=CE=B1 while increasing the anti-inflammatory cytokine I= L-10.=0A=0AThen there's a 2025 study from Rowan University. Dihexa dose-dep= endently improved working memory after repeated mild traumatic brain injury= . =0A=0AAs someone who played football and has had multiple concussions, th= e TBI angle is near and dear to me. This is where I think Dihexa has some r= eal untapped potential.=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**Dosing and How I Us= e It**=0A=0ALet me share what I covered in the video about dosing. Keep in = mind this is based on community experience and the underground nootropic sp= ace.=0A=0AOral capsules are the most common route. The typical range is 5 t= o 40 mg. Personally, 10 mg is the sweet spot. At 5 mg, I notice something s= ubtle. At 10 mg, I get a solid cognitive bump without being pushed too far.= =0A=0AFor subcutaneous injection, I'd stay around 1 to 3 mg 2-3 times per w= eek. Injection is 100% bioavailable, compared with roughly 38% for oral adm= inistration. =0A=0AI like to take the oral capsules three times per week, o= r sometimes just on days when I know I need to be locked in for deep work.= =0A=0AGiven the long half-life, you really don't need daily dosing. Two to = three times per week gives you solid benefit without unnecessary accumulati= on.=0A=0AFor cycling, I recommend 8 to 12 weeks on, then two to four weeks = off. And on your off days, consider taking alpha-GPC to help replenish neur= otransmitters. That's a great support compound for any nootropic protocol.= =0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=0A=0A**Final Thoughts**=0A=0AHere's my honest take= on Dihexa.=0A=0AEvery time I take it, I get a noticeable effect. The cogni= tive clarity and focus are tangible. Not overwhelming. Not personality-alte= ring. Just a clean bump in processing power when I need it.=0A=0AWill we ev= er have extensive clinical data on Dihexa itself? Probably not. No pharmace= utical company is going to invest hundreds of millions to take a simple pep= tide through FDA approval when they can't patent it. The economics don't wo= rk. =0A=0AFor age-related cognitive decline, I think Dihexa could be genuin= ely helpful. For TBI recovery, I'd absolutely include it alongside Cerebrol= ysin, BPC-157, and TB-500. =0A=0AFor healthy folks who want a cognitive edg= e without the heavy push of something like Modafinil, it's a great fit.=0A= =0AStart low. Work your way up. Cycle responsibly. Don't be the person who = jumps to 40 mg a day because someone on the internet told you to.=0A=0AThan= k you for your support of my work!=0A=0ABest,=0A=0AHunter Williams=0A=0AP.S= . You can get Dihexa from the following places:=0A=0A* [BioLongevity Labs c= ode HUNTERW (it=E2=80=99s an ingredient in BioMind alongside Noopept and J-= 147)](https://biolongevitylabs.com/product/biomind/?_gl=3D17ettte_upMQ.._ga= MTM2NTU5NDA2Mi4xNzc0MzczNTI0_ga_QESWFYYLJD*czE3NzQzNzM1MjMkbzEkZzAkdDE3NzQz= NzM1MjMkajYwJGwwJGgxMzczMDM2MjYx)=0A=0A* [Parabolic Peptides code TAYLORW (= just pure dihexa)](https://parabolicpeptides.com/shop/ols/products/dihexa-5= mg60qty)=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**Further Reading**=0A=0A* [https://= pubmed.ncbi.nlm.nih.gov/34827486/](https://pubmed.ncbi.nlm.nih.gov/34827486= /)=0A=0A* [https://www.liebertpub.com/doi/full/10.1177/2689288X251392851](h= ttps://www.liebertpub.com/doi/full/10.1177/2689288X251392851)=0A=0A=0A=E2= =80=94=E2=80=94=E2=80=94=0A=0AYou are reading a plain text version of this = post. For the best experience, copy and paste this link in your browser to = view the post online:=0Ahttps://huntershealthhacks.beehiiv.com/p/dihexa-dee= p-dive --BNbOu2hoQIK2VdRZ6vKUsQ Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Dihexa Deep Dive
New video is live!  ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌
=

March 24, 2026   |   Read online

Dihexa Deep Dive

New video is live!

=
3D"share
&nb= sp;
3D"share
 =
 
3D"share
3D""
<= /tr>

The end result is synaptogenesis.

=

Happy= Tuesday!

I just dropped a = brand new deep dive video over on Spotify. This one is all about Dihexa.

=
 
=

=

Dihexa Deep Dive | Dosi= ng, Safety, and Why I Keep Coming Back to It

The Hunter Williams Podcast =C2=B7 Episode

open.spotify.com/episo= de/1AgU8pUfumBRW3W5UiYpnu?si=3Dk8U0UKEYR9Wwevbsh5cSTg

 

I genuinely think Dihexa is one of the most = underappreciated compounds in the cognitive enhancement space right now.

If you've been following m= e for a while, you know I'm not really a nootropics guy.

= When you're hormonally optimized and = running peptides, you get a lot of cognitive function as a byproduct. I don= 't need to push the gas pedal too often.

But Dihexa is different.

It sits in this perfect middle ground for me. Strong enough t= hat I actually feel it working. Not so strong that I lose my personality or= start feeling like a robot. I like operating as a human being with empathy= and social awareness, and some nootropics can strip that away.

<= /td>

In today=E2=80=99s email, I will break = down what I covered in the video.

 =

Dihexa

Dihexa is a synthetic peptide dev= eloped over two decades at Washington State University. It was derived from= angiotensin IV.

What mak= es it special is that it promotes synaptogenesis, meaning it helps your bra= in form brand new synaptic connections between neurons.

 

How It Works in the Brain

Dihexa binds to hepatocyte growth factor (HGF). That binding helps HG= F dimerize. Once that happens, it activates the c-Met receptor tyrosine kin= ase on the surface of your neurons. This initiates downstream signaling via= the PI3K/AKT pathway and the MAPK/ERK cascade.

New synaptic connections form in your hippocampu= s and other brain regions responsible for learning and memory.

It also crosses the blood-brain barrier = when taken orally. Most neurotrophic factors can't do that. Dihexa can,= thanks to its engineered lipophilicity and small molecular size.

One more interesting detail. The half= -life is around 12 to 13 days. That's extraordinarily long. It means yo= u get a cumulative effect when dosing regularly. It also means you probably= don't need to take it every single day.

 

Studi= es

A 2021 study out of C= hina Pharmaceutical University confirmed that oral Dihexa improved spatial = learning in APP/PS1 mice.

It increased neuronal cell counts, elevated synaptophysin expression, and = reduced neuroinflammation. Specifically, it decreased IL-1=CE=B2 and TNF-= =CE=B1 while increasing the anti-inflammatory cytokine IL-10.

= Then there's a 2025 study from Rowan = University. Dihexa dose-dependently improved working memory after repeated = mild traumatic brain injury.

As someone who played football and has had multiple concussions, the TBI = angle is near and dear to me. This is where I think Dihexa has some real un= tapped potential.

<= /tr>

Hunter Williams

<= /tr><= /table>
 

Dosing and How I Use It=

Let me share what I covered in the= video about dosing. Keep in mind this is based on community experience and= the underground nootropic space.

Oral capsules are the most common route. The typical range is 5 to 40= mg. Personally, 10 mg is the sweet spot. At 5 mg, I notice something subtl= e. At 10 mg, I get a solid cognitive bump without being pushed too far.

For subcutaneous injection, I&#= 39;d stay around 1 to 3 mg 2-3 times per week. Injection is 100% bioavailab= le, compared with roughly 38% for oral administration.

I like to take the oral capsules three times pe= r week, or sometimes just on days when I know I need to be locked in for de= ep work.

Given the long half= -life, you really don't need daily dosing. Two to three times per week = gives you solid benefit without unnecessary accumulation.

For cycling, I recommend 8 to 12 weeks on, th= en two to four weeks off. And on your off days, consider taking alpha-GPC t= o help replenish neurotransmitters. That's a great support compound for= any nootropic protocol.

=
 

Final Thoughts

Here's my honest take on Dihexa.=

Every time I take it, I get= a noticeable effect. The cognitive clarity and focus are tangible. Not ove= rwhelming. Not personality-altering. Just a clean bump in processing power = when I need it.

Will we ever= have extensive clinical data on Dihexa itself? Probably not. No pharmaceut= ical company is going to invest hundreds of millions to take a simple pepti= de through FDA approval when they can't patent it. The economics don= 9;t work.

For age-related c= ognitive decline, I think Dihexa could be genuinely helpful. For TBI recove= ry, I'd absolutely include it alongside Cerebrolysin, BPC-157, and TB-5= 00.

For healthy folks who w= ant a cognitive edge without the heavy push of something like Modafinil, it= 's a great fit.

Start lo= w. Work your way up. Cycle responsibly. Don't be the person who jumps t= o 40 mg a day because someone on the internet told you to.

Thank you for your support of my work!

Best,

P.S. You can get Dihexa from the following places:

 

Further Reading

=
<= tr>=

=F0=9F=91=89Link To All My Old Videos:

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