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[149.72.166.62]) by mx.google.com with ESMTPS id af79cd13be357-8cfc8f5f778si1168051385a.22.2026.03.22.20.00.23 for (version=TLS1_3 cipher=TLS_AES_128_GCM_SHA256 bits=128/128); Sun, 22 Mar 2026 20:00:24 -0700 (PDT) Received-SPF: pass (google.com: domain of bounces+35285666-9e1b-tjphuhs=gmail.com@mail.blueprint.bryanjohnson.com designates 149.72.166.62 as permitted sender) client-ip=149.72.166.62; Authentication-Results: mx.google.com; dkim=pass header.i=@blueprint.bryanjohnson.com header.s=kl header.b=RBgL5WCl; dkim=pass header.i=@sendgrid.info header.s=smtpapi header.b=pSeBiVdE; spf=pass (google.com: domain of bounces+35285666-9e1b-tjphuhs=gmail.com@mail.blueprint.bryanjohnson.com designates 149.72.166.62 as permitted sender) smtp.mailfrom="bounces+35285666-9e1b-tjphuhs=gmail.com@mail.blueprint.bryanjohnson.com"; dmarc=pass (p=QUARANTINE sp=QUARANTINE dis=NONE) header.from=bryanjohnson.com DKIM-Signature: v=1; a=rsa-sha256; c=relaxed/relaxed; d=blueprint.bryanjohnson.com; h=content-type:date:from:mime-version:subject:feedback-id: list-unsubscribe:list-unsubscribe-post:to:cc:content-type:date:feedback-id:from: subject:to; s=kl; t=1774234822; bh=CN7JZBn6SQOhyJyz9LzPG5U0RsK6iy3te+2dL/vWsfw=; b=RBgL5WClHPzpMXMSqqH8VIK6wadNWxuSFROqaKwNIVLsEMytRiQXx05eZO+bva7Tcjjv D1Tl/2/Pk74t/h2GDKqYF9fiNIr9Vg+stzTL6JIzlUsbi8L3FCdtXsC9Ne7ei6y2XMqME0 0+NyLMe2GxDRI6f9Fm5gE0ROebfLWM2pHfL4IJGjqkiJyRW30sgvtOPNbdF9D43crTxBAp u22fTjPYwxUnp+MArduXpH7ZY2ANjBWob+drZb8Jsx1fTqZOPwv2ueaQ7GCPsAU4JJzK+e tFKaHP0wd9ZcHqE3SxouIFmbO146dBueRyvVeBrr0Xo/tCKLvyMA0PbNEoxqMOyw== DKIM-Signature: v=1; a=rsa-sha256; c=relaxed/relaxed; d=sendgrid.info; h=content-type:date:from:mime-version:subject:feedback-id: list-unsubscribe:list-unsubscribe-post:to:cc:content-type:date:feedback-id:from: subject:to; s=smtpapi; t=1774234822; bh=CN7JZBn6SQOhyJyz9LzPG5U0RsK6iy3te+2dL/vWsfw=; b=pSeBiVdE9Rh+M6hPK5ZdfcRBRKR9C2WP/OAfBk0uqM9h98p0UGBr2WzwZLm4D3/zMJMk dRerf8cqbip0kCES0x5LeVkE0IJVFD5Kp1ujRdnTIWxqOe0gruVCBvSRWaGwTJUlPgP7cU lad3vbLr46RS9HIeBIMnL4lGSVIagsFOQ= Received: by recvd-6c8dd88c66-thr49 with SMTP id recvd-6c8dd88c66-thr49-1-69C0ACC6-1CD 2026-03-23 03:00:22.858443147 +0000 UTC m=+1151116.053035698 Received: from MzUyODU2NjY (unknown) by geopod-ismtpd-26 (SG) with HTTP id s4_S4zpMSBKNpfUJnJm1ow Mon, 23 Mar 2026 03:00:22.856 +0000 (UTC) Content-Type: multipart/alternative; boundary=d2c5e3d49745e66a8a868127f7df63800d181c0b37cfe2d239de6631c39c Date: Mon, 23 Mar 2026 03:00:22 +0000 (UTC) From: Bryan Johnson Mime-Version: 1.0 Message-ID: Subject: we made a metabolic discovery Feedback-ID: 01KKA4J24M8K8TYVAXVTXWR1FN:UDtiqU:27885238018:kl List-Unsubscribe: =?us-ascii?Q?=3Chttps=3A=2F=2Fmanage=2Ekmail-lists=2Ecom=2Fsubscriptions=2Funsubscribe=3Fa=3DUD?= =?us-ascii?Q?tiqU&c=3D01KJT9DP2RVS1CVFD3BD75ZESG&k=3D450?= =?us-ascii?Q?25595cf22049e7e57727e73cdc99b&m=3D01KM6N2?= =?us-ascii?Q?V5H8BSMY7B89G2XD7ZN&r=3D01KMC99RAN0CDEQQW?= =?us-ascii?Q?5PS9Q5VSY=3E?= List-Unsubscribe-Post: List-Unsubscribe=One-Click X-Kmail-Account: UDtiqU X-Kmail-Message: 01KM6N2V5H8BSMY7B89G2XD7ZN X-Kmail-Ops: 01KJT9DP2RVS1CVFD3BD75ZESG X-Report-Abuse: Please report any spam or abuse to: abuse@klaviyo.com X-SG-EID: =?us-ascii?Q?u001=2ERSkxLJ=2F7dOz8Izq79rm58aaqrRoQvgOtDRPqri4s8wUs60RmWNByvvjh6?= =?us-ascii?Q?nYet8g+DuLDqQQYEBieqRBg68mMpeFGKU2yJlMm?= =?us-ascii?Q?zEREPCjv1FnOoqycLEdLVH+OBsV=2F1vPIcFO3c4S?= =?us-ascii?Q?1B7IurYagS4RPewczuRb0sngBucn6AUSXSajOfd?= =?us-ascii?Q?2+5eaX161SHIqZ7WyWswcBLMiKzIWJ2AqtARxPz?= =?us-ascii?Q?QgZWcEYyUA+hX9EGMEIZh29u9xOy1cAUkq8eBRs?= =?us-ascii?Q?jw3G?= X-SG-ID: =?us-ascii?Q?u001=2ESdBcvi+Evd=2FbQef8eZF3BiU3Zi1S53GtqGa3TWBmqe75yn5aYrkvkfG+Z?= =?us-ascii?Q?GKrHRvqCI1cV9HjBz0XvSghBglTQltvhoA8bXxy?= =?us-ascii?Q?HibePBmuHY9dYowZ3YKEvrkeqsmVouILT1QzI8Y?= =?us-ascii?Q?Qj+vzWdAtxDsbHc2aQnd440hW+7AnTdj=2FYVLdxj?= =?us-ascii?Q?cZxk1mJmTTgsURDYWKTQHy4PiaIc+E7NcH8weCI?= =?us-ascii?Q?Vd1OUIGgUTqtF8XJfcIH2zmVIhIYpuq+fonuMoe?= =?us-ascii?Q?dx55sUvzh0xNHJqPLA6E9Udpa+VxaG3krdVU1c7?= =?us-ascii?Q?PqEn2bx2wF3Lm=2Fva8BPfdKiWrH4smL0EiUoQ7+r?= =?us-ascii?Q?vOu2xbFkGFLQTCHEL1laoZ9SPdjs76BVUzTVZNZ?= =?us-ascii?Q?gOCtpOdl6DU4FiK?= To: tjphuhs@gmail.com X-Entity-ID: u001.jUcd5nuE7bFtshTLUhoRtg== --d2c5e3d49745e66a8a868127f7df63800d181c0b37cfe2d239de6631c39c Content-Transfer-Encoding: quoted-printable Content-Type: text/plain; charset=utf-8 Mime-Version: 1.0 [Blueprint Homepage](https://blueprint.bryanjohnson.com) Hi friend,=C2=A0 =C2=A0 This is email 3 in a 3-part series on magic mushrooms. =C2=A0 In the last two emails, I shared why we began testing psilocybin as a poten= tial longevity therapy, the scientific rationale behind it, and the fully q= uantified protocol measuring 249 biomarkers across three medically supervis= ed doses ([read more here](https://blueprint.bryanjohnson.com/blogs/news/ma= gic-mushrooms)).=C2=A0 =C2=A0 Note: I took magic mushrooms under medical supervision. Speak with your doc= tor if you have questions. =C2=A0 I reported early results, including a >35% reduction in systemic inflammati= on, youthful shifts in brain network activity, a normal but contained corti= sol response, and my subjective experience ([read more here](https://bluepr= int.bryanjohnson.com/blogs/news/magic-mushroom-biomarker-results)). =C2=A0 Today, I am sharing an unexpected finding=E2=80=A6 =C2=A0 Mushrooms may hit a metabolic reset button in the brain, improving blood su= gar control drastically. This is a first in-human observation.=C2=A0 https://blueprint.bryanjohnson.com/ https://blueprint.bryanjohnson.com/ =E2=80=94 =C2=A0 My blood sugar results=C2=A0 - + before: top 2% of population + after: top 0.2% of population + better than 99.75% of 18-25 yr olds + mean glucose dropped 8% + time above 125 mg/dL: zero min + variability dropped 11% A single session of mushrooms reduced my estimated HbA1c from 4.7% to 4.4%,= a relative reduction of 6.8%. The positive effect was still as strong on d= ay 3 post-dose as it was on day 1. =C2=A0 Why does this matter? =C2=A0 We treat diabetes and metabolic dysfunction with chronic daily medication (= metformin, insulin, GLP-1s). This data suggests that a neuroplastic event m= ight have downstream effects on the liver and pancreas that mimic or exceed= these drugs. =C2=A0 For context, taking metformin daily takes 6 months to drop blood glucose 10= -15%.=C2=A0 =C2=A0 =E2=80=94 =C2=A0 Thermal map =C2=A0 We also have another world-first=E2=80=A6 the first-ever face and upper bod= y thermal map of a mushroom journey. https://blueprint.bryanjohnson.com/ https://blueprint.bryanjohnson.com/ =C2=A0We found... - + my core body temp increased 1.5-2=C2=B0F (~1=C2=B0C), matching human st= udies in which 30 mg psilocybin raises temperature by 1.8=C2=B0F (1.0=C2=B0= C) + my upper chest and throat increased 2.5=C2=B0F (1.4=C2=B0C), producing a = thoracic heat bloom visible in the thermal image + my nose and lips cooled significantly, showing emotional intensity, sadne= ss, and arousal + my cheeks warmed, showing joy, connection, happiness, and subtle sadness + my forehead cooled, showing cognitive effort and introspection + my arms cooled, showing peripheral vasoconstriction Overall, there was sympathetic activation, peripheral vasoconstriction, and= increased cardiovascular load, leading to increased core and reduced perip= heral blood flow. =C2=A0 Around the peak (2.5 hrs), my heart rate was still elevated by 15 bpm (55 b= pm to 70 bpm), and interestingly, my fingertip SpO=E2=82=82 was decreased b= y 5% (99% to 94%), both consistent with lasting sympathetic activation. =C2=A0 =E2=80=94 =C2=A0 What=E2=80=99s next?=C2=A0 =C2=A0 Pending data:=C2=A0 - + telomere length and relative telomerase activity (telomere regeneration= capacity) + epigenetic measurements + microbiome The data we have so far is promising. I=E2=80=99ll continue to share any re= sults. Follow along [on X](https://x.com/bryan_johnson).=C2=A0 =C2=A0=C2=A0 Be well,=C2=A0 Bryan=C2=A0 =C2=A0 =C2=A0 Note: I took magic mushrooms under medical supervision, in a legal setting,= and with a professional facilitator. This email reflects my personal exper= ience and interpretation of early-stage research. The information shared is= exploratory and educational in nature, not medical advice, and not intende= d as guidance or recommendations for others. If you're curious for yourself= , speak with your doctor. [Blueprint](https://blueprint.bryanjohnson.com/) Most emails suck. We're trying not to. What did you think of this email? 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from magic mushrooms=E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F = =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87= =CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2= =80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD= =8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80= =87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F = =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87= =CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2= =80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD= =8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80= =87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F = =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87= =CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2= =80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD= =8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80= =87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F = =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87= =CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2= =80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD= =8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80= =87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F = =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87= =CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2= =80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD= =8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80= =87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F = =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87= =CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2= =80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD= =8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80= =87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F = =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87= =CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =E2=80=87=CD=8F =C2= =AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD = =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2= =AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD = =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2= =AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD = =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2= =AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD = =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2= =AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD = =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2= =AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD = =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2= =AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD = =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2=AD =C2= =AD =C2=AD =C2=AD
3D""=
Hi friend, 
 
This is email 3 in a 3-part series on= magic mushrooms.
 
In the last two emails, I shared why = we began testing psilocybin as a potential longevity therapy, the scientifi= c rationale behind it, and the fully quantified protocol measuring 249 biom= arkers across three medically supervised doses (read more here). 
 
Note: I took magic mushrooms under me= dical supervision. Speak with your doctor if you have questions.
 
I reported early results, including a= >35% reduction in systemic inflammation, youthful shifts in brain netwo= rk activity, a normal but contained cortisol response, and my subjective ex= perience (read more here).<= /span>
 
Today, I am sharing an unexpected fin= ding=E2=80=A6
 
Mushrooms may hit a metabolic reset b= utton in the brain, improving blood sugar control drastically. This is a fi= rst in-human observation. 
3D""
3D""
=E2=80=94
 
My blood sugar results <= /strong>
  • + before: top 2% of populatio= n
    + after: top 0.2% of population
    + better than 99.75% of 18-25 yr ol= ds
    + mean glucose dropped 8%
    + time above 125 mg/dL: zero min
    + va= riability dropped 11%
A single session of = mushrooms reduced my estimated HbA1c from 4.7% to 4.4%, a relative reductio= n of 6.8%. The positive effect was still as strong on day 3 post-dose as it= was on day 1.
 
Why does = this matter?
 
We treat diabetes and metabolic dysfu= nction with chronic daily medication (metformin, insulin, GLP-1s). This dat= a suggests that a neuroplastic event might have downstream effects on the l= iver and pancreas that mimic or exceed these drugs.
 
For context, taking metformin daily t= akes 6 months to drop blood glucose 10-15%. 
 
=E2=80=94
 
T= hermal map
 
We also have another world-first=E2= =80=A6 the first-ever face and upper body thermal map of a mushroom journey= .
3D""
3D""
 We found...
  • + my core b= ody temp increased 1.5-2=C2=B0F (~1=C2=B0C), matching human studies in whic= h 30 mg psilocybin raises temperature by 1.8=C2=B0F (1.0=C2=B0C)
    + my up= per chest and throat increased 2.5=C2=B0F (1.4=C2=B0C), producing a thoraci= c heat bloom visible in the thermal image
    + my nose and lips cooled sign= ificantly, showing emotional intensity, sadness, and arousal
    + my cheeks= warmed, showing joy, connection, happiness, and subtle sadness
    + my for= ehead cooled, showing cognitive effort and introspection
    + my arms coole= d, showing peripheral vasoconstriction
Overall, there was sympathetic activa= tion, peripheral vasoconstriction, and increased cardiovascular load, leadi= ng to increased core and reduced peripheral blood flow.
 
Around the peak (2.5 hrs), my heart r= ate was still elevated by 15 bpm (55 bpm to 70 bpm), and interestingly, my = fingertip SpO=E2=82=82 was decreased by 5% (99% to 94%), both consistent wi= th lasting sympathetic activation.
 
=E2=80=94
 
What=E2=80=99s next? 
 
Pending data: 
  • + telomere length and relativ= e telomerase activity (telomere regeneration capacity)
    + epigenetic meas= urements
    + microbiome
The data we have so far is promising.= I=E2=80=99ll continue to share any results. Follow along on X. 
 &n= bsp;
Be well, 
Bryan 
 
 
Note: I took magic mushrooms under medical supervision, in a = legal setting, and with a professional facilitator. This email reflects my = personal experience and interpretation of early-stage research. The informa= tion shared is exploratory and educational in nature, not medical advice, a= nd not intended as guidance or recommendations for others. If you're curiou= s for yourself, speak with your doctor.
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