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Subject: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
From: Derek from Peptide Price <derekpruski@substack.com>
To: tjphuhs@gmail.com
Message-Id: <20260319113726.3.d8d40b9fd48edc89@mg-d1.substack.com>
Date: Thu, 19 Mar 2026 11:37:26 +0000
Feedback-Id: post-191466016:cat-post:pub-3365367:substack
Sender: Derek from Peptide Price <derekpruski@substack.com>
References: <post-191466016@substack.com>
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Reply-To: Derek from Peptide Price
 <reply+35zs4g&4iwoe6&&c1514736830119f9c9ae5e844b086d1510a08723a5169d938401b2e980cf2ca0@mg1.substack.com>

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View this post on the web at https://derekpruski.substack.com/p/long-covid-=
and-mitochondrial-peptides

This post is for educational and informational purposes only. None of this =
is medical advice, none of this is intended to diagnose or treat any diseas=
e or condition, and none of this should be taken as a recommendation to use=
 any compound for any purpose. All compounds referenced are research use on=
ly. Always consult with a qualified medical professional before making any =
decisions about your health.
This is one of the more interesting topics I=E2=80=99ve been sitting on for=
 a while, and it keeps coming up enough in research circles that it deserve=
s a thorough breakdown.
Long COVID has affected a significant number of people, and conventional me=
dicine has largely struggled to explain why some individuals never fully re=
cover. What=E2=80=99s emerging from the research, however, points toward a =
very specific and compelling mechanism =E2=80=94 and it opens up an interes=
ting conversation about compounds that directly target that mechanism.
Let=E2=80=99s start from the beginning...

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}</style></head><body class=3D"email-body" style=3D"font-kerning: auto;--im=
age-offset-margin: -120px;"><img src=3D"https://eotrx.substackcdn.com/open?=
token=3DeyJtIjoiPDIwMjYwMzE5MTEzNzI2LjMuZDhkNDBiOWZkNDhlZGM4OUBtZy1kMS5zdWJ=
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lor:#333333;line-height:1px;max-height:0px;max-width:0px;opacity:0;overflow=
:hidden;">This post is for educational and informational purposes only.</di=
v><div class=3D"preview" style=3D"display:none;font-size:1px;color:#333333;=
line-height:1px;max-height:0px;max-width:0px;opacity:0;overflow:hidden;">&#=
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nbsp; &#8199; &#173;&#847; &nbsp; &#8199; &#173;</div><table class=3D"email=
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ing=3D"0" cellpadding=3D"0"><tbody><tr><td></td><td class=3D"content" width=
=3D"550"></td><td></td></tr><tr><td></td><td class=3D"content" width=3D"550=
" align=3D"left"><div style=3D"font-size: 16px;line-height: 26px;max-width:=
 550px;width: 100%;margin: 0 auto;overflow-wrap: break-word;"><table role=
=3D"presentation" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=
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"presentation" width=3D"auto" border=3D"0" cellspacing=3D"0" cellpadding=3D=
"0"><tbody><tr><td style=3D"vertical-align:middle;"><span class=3D"pencraft=
 pc-reset reset-IxiVJZ tw-font-body tw-text-ssm tw-text-substack-secondary"=
 style=3D"font-family: SF Pro Text, -apple-system, system-ui, BlinkMacSyste=
mFont, Inter, Segoe UI, Roboto, Helvetica, Arial, sans-serif, Apple Color E=
moji, Segoe UI Emoji, Segoe UI Symbol;font-size: 13px;color: unset;list-sty=
le: none;text-decoration: unset;margin: 0;"><div class=3D"pencraft pc-reset=
 align-right-VJbKw5 size-12-mmZ61m reset-IxiVJZ" style=3D"list-style: none;=
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ation: unset;margin: 0;"><span class=3D"pencraft pc-reset reset-IxiVJZ" tra=
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G9jaG9uZHJpYWwtcGVwdGlkZXMiLCJwIjoxOTE0NjYwMTYsInMiOjMzNjUzNjcsImYiOnRydWUs=
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ne-height: 26px;"><div class=3D"post-header" role=3D"region" aria-label=3D"=
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lign: start;unicode-bidi: isolate;color: rgb(54,55,55);font-family: 'SF Pro=
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ased;-moz-osx-font-smoothing: antialiased;-webkit-appearance: optimizelegib=
ility;-moz-appearance: optimizelegibility;appearance: optimizelegibility;ma=
rgin: 0;line-height: 36px;font-size: 32px;"><a href=3D"https://substack.com=
/app-link/post?publication_id=3D3365367&post_id=3D191466016&utm_source=3Dpo=
st-email-title&utm_campaign=3Demail-post-title&isFreemail=3Dtrue&r=3D4iwoe6=
&token=3DeyJ1c2VyX2lkIjoyNzM2MjIzOTgsInBvc3RfaWQiOjE5MTQ2NjAxNiwiaWF0IjoxNz=
czOTIwMjQ5LCJleHAiOjE3NzY1MTIyNDksImlzcyI6InB1Yi0zMzY1MzY3Iiwic3ViIjoicG9zd=
C1yZWFjdGlvbiJ9.uITDSdtJH3LBJv63lLavoqmQZsB2f3hiGfWzebWwnC4" style=3D"color=
: rgb(54,55,55);text-decoration: none;">Long COVID &amp; Mitochondrial Pept=
ides: What the Research Actually Suggests</a></h1><table class=3D"post-meta=
" role=3D"presentation" width=3D"100%" border=3D"0" cellspacing=3D"0" cellp=
adding=3D"0" style=3D"margin: 1em 0;height: 20px;align-items: center;"><tbo=
dy><tr><td><table role=3D"presentation" width=3D"auto" border=3D"0" cellspa=
cing=3D"0" cellpadding=3D"0"><tbody><tr><td><table role=3D"presentation" wi=
dth=3D"auto" border=3D"0" cellspacing=3D"0" cellpadding=3D"0"><tbody><tr><t=
d style=3D"vertical-align:middle;"><div class=3D"pencraft pc-reset color-pr=
imary-zABazT line-height-20-t4M0El font-meta-MWBumP size-11-NuY2Zx weight-m=
edium-fw81nC transform-uppercase-yKDgcq reset-IxiVJZ meta-EgzBVA custom-css=
-email-post-author" style=3D"list-style: none;font-size: 11px;line-height: =
20px;text-decoration: unset;color: rgb(54,55,55);margin: 0;font-family: 'SF=
 Compact',-apple-system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe U=
I',Roboto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','=
Segoe UI Symbol';font-weight: 500;text-transform: uppercase;letter-spacing:=
 .2px;"><a class=3D"pencraft pc-reset color-primary-zABazT line-height-20-t=
4M0El font-meta-MWBumP size-11-NuY2Zx weight-medium-fw81nC transform-upperc=
ase-yKDgcq reset-IxiVJZ meta-EgzBVA" style=3D"list-style: none;color: rgb(5=
4,55,55);margin: 0;font-size: 11px;line-height: 20px;font-family: 'SF Compa=
ct',-apple-system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI',Rob=
oto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','Segoe =
UI Symbol';font-weight: 500;text-transform: uppercase;letter-spacing: .2px;=
text-decoration: none" href=3D"https://substack.com/@peptideprice">Derek</a=
></div></td></tr></tbody></table></td></tr><tr><td><table role=3D"presentat=
ion" width=3D"auto" border=3D"0" cellspacing=3D"0" cellpadding=3D"0"><tbody=
><tr><td style=3D"vertical-align:middle;"><div class=3D"pencraft pc-reset c=
olor-secondary-ls1g8s line-height-20-t4M0El font-meta-MWBumP size-11-NuY2Zx=
 weight-medium-fw81nC transform-uppercase-yKDgcq reset-IxiVJZ meta-EgzBVA" =
style=3D"list-style: none;font-size: 11px;line-height: 20px;text-decoration=
: unset;color: rgb(119,119,119);margin: 0;font-family: 'SF Compact',-apple-=
system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI',Roboto,Helveti=
ca,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','Segoe UI Symbol';=
font-weight: 500;text-transform: uppercase;letter-spacing: .2px;"><time dat=
etime=3D"2026-03-19T11:37:25.874Z">Mar 19</time></div></td><td width=3D"4" =
style=3D"min-width:4px;"></td><td style=3D"vertical-align:middle;"><table r=
ole=3D"presentation" width=3D"auto" border=3D"0" cellspacing=3D"0" cellpadd=
ing=3D"0"><tbody><tr><td style=3D"vertical-align:middle;"><div class=3D"pen=
craft pc-reset color-secondary-ls1g8s line-height-20-t4M0El font-meta-MWBum=
P size-11-NuY2Zx weight-medium-fw81nC transform-uppercase-yKDgcq reset-IxiV=
JZ meta-EgzBVA" style=3D"list-style: none;font-size: 11px;line-height: 20px=
;text-decoration: unset;color: rgb(119,119,119);margin: 0;font-family: 'SF =
Compact',-apple-system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI=
',Roboto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','S=
egoe UI Symbol';font-weight: 500;text-transform: uppercase;letter-spacing: =
=2E2px;">&#8729;</div></td><td width=3D=
"4" style=3D"min-width:4px;"></td><td=20=
style=3D"vertical-align:middle;"><div class=3D"pencraft pc-reset color-paid=
-LmY0EP line-height-20-t4M0El font-meta-MWBumP size-11-NuY2Zx weight-medium=
-fw81nC transform-uppercase-yKDgcq reset-IxiVJZ meta-EgzBVA" translated=3D"=
" style=3D"list-style: none;font-size: 11px;line-height: 20px;text-decorati=
on: unset;color: rgb(94,73,217);margin: 0;font-family: 'SF Compact',-apple-=
system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI',Roboto,Helveti=
ca,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','Segoe UI Symbol';=
font-weight: 500;text-transform: uppercase;letter-spacing: .2px;">Preview</=
div></td></tr></tbody></table></td></tr></tbody></table></td></tr></tbody><=
/table></td><td align=3D"right"><table role=3D"presentation" width=3D"auto"=
 border=3D"0" cellspacing=3D"0" cellpadding=3D"0"><tbody><tr><td style=3D"v=
ertical-align:middle;"><a href=3D"https://substack.com/@peptideprice"><img =
class=3D"custom-css-email-avatar avatar-QIQ5yR" src=3D"https://substackcdn.=
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-43a0-af70-e96356c0f3f3_500x500.png" style=3D"box-sizing: border-box;max-wi=
dth: 550px;border: none;vertical-align: middle;width: 40px;height: 40px;min=
-width: 40px;min-height: 40px;object-fit: cover;margin: 0px;display: inline=
;border-radius: 50%" width=3D"40" height=3D"40"></a></td></tr></tbody></tab=
le></td></tr></tbody></table><table class=3D"email-ufi-2-top" role=3D"prese=
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,0,.1);min-width: 100%;"><tbody><tr height=3D"16"><td height=3D"16" style=
=3D"font-size:0px;line-height:0;">&nbsp;</td></tr><tr><td><table role=3D"pr=
esentation" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0"=
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</tr></tbody></table></td></tr></tbody></table></td></tr><tr height=3D"16">=
<td height=3D"16" style=3D"font-size:0px;line-height:0;">&nbsp;</td></tr></=
tbody></table></div></div><div class=3D"post typography" dir=3D"auto" style=
=3D"--image-offset-margin: -120px;padding: 32px 0 0 0;font-size: 16px;line-=
height: 26px;"><div class=3D"body markup" dir=3D"auto" style=3D"text-align:=
 initial;font-size: 16px;line-height: 26px;width: 100%;word-break: break-wo=
rd;margin-bottom: 16px;"><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55=
);line-height: 26px;font-size: 16px;margin-top: 0;"><em>This post is for ed=
ucational and informational purposes only. None of this is medical advice, =
none of this is intended to diagnose or treat any disease or condition, and=
 none of this should be taken as a recommendation to use any compound for a=
ny purpose. All compounds referenced are research use only. Always consult =
with a qualified medical professional before making any decisions about you=
r health.</em></p><div style=3D"font-size: 16px;line-height: 26px;"><hr sty=
le=3D"margin: 32px 0;padding: 0;height: 1px;background: rgb(0,0,0,.1);borde=
r: none;"></div><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-he=
ight: 26px;font-size: 16px;">This is one of the more interesting topics I&#=
8217;ve been sitting on for a while, and it keeps coming up enough in resea=
rch circles that it deserves a thorough breakdown.</p><p style=3D"margin: 0=
 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">Long COV=
ID has affected a significant number of people, and conventional medicine h=
as largely struggled to explain why some individuals never fully recover. W=
hat&#8217;s emerging from the research, however, points toward a very speci=
fic and compelling mechanism &#8212; and it opens up an interesting convers=
ation about compounds that directly target that mechanism.</p><p style=3D"m=
argin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;ma=
rgin-bottom: 0;">Let&#8217;s start from the beginning...</p></div></div><di=
v class=3D"paywall paywall-white-background" data-testid=3D"paywall" data-c=
omponent-name=3D"Paywall" role=3D"region" aria-label=3D"Paywall" style=3D"p=
osition: relative;font-family: system-ui,-apple-system,BlinkMacSystemFont,'=
Segoe UI',Roboto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI E=
moji','Segoe UI Symbol';text-align: center;margin-bottom: 16px;cursor: defa=
ult;-webkit-user-select: none;-moz-user-select: none;-ms-user-select: none;=
user-select: none;line-height: 26px;font-size: 16px;padding: 32px 24px 16px=
 24px;background: rgb(255,255,255);color: rgb(54,55,55);border-top: solid 2=
px #ff6719;margin-top: 6px;"><div class=3D"pencraft pc-display-flex pc-widt=
h-64 pc-height-64 pc-justifyContent-center pc-alignItems-center pc-position=
-relative pc-reset bg-secondary-UUD3_J flex-auto-j3S2WA outline-detail-vcQL=
yr pc-borderRadius-full overflow-hidden-WdpwT6 sizing-border-box-DggLA4 con=
tainer-TAtrWj paywall-unlock-avatar-static" style=3D"margin: auto;text-deco=
ration: unset;list-style: none;border-radius: 9999px;display: flex;position=
: relative;justify-content: center;align-items: center;width: 64px;height: =
64px;outline: 1px solid rgb(0,0,0,.1);outline-offset: -1px;background-color=
: rgb(238,238,238);flex: none;overflow: hidden;box-sizing: border-box;-webk=
it-user-select: none;user-select: none;font-size: 16px;line-height: 26px;--=
scale: 64px"><div class=3D"pencraft pc-display-flex pc-width-64 pc-height-6=
4 pc-justifyContent-center pc-alignItems-center pc-position-relative pc-res=
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