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From: TJ Bourdeau <tjphuhs@gmail.com>
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Date: Mon, 16 Mar 2026 10:27:30 -0400
Subject: Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Message-Id: <79D31172-1CBE-40C2-B738-175776D4AAA4@gmail.com>
References: <20260316142504.3.995cce27ee027500@mg-d0.substack.com>
To: oc.tjphuhs@gmail.com
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v=3D"content-type" content=3D"text/html; charset=3Dutf-8"></head><body dir=3D=
"auto"><br id=3D"lineBreakAtBeginningOfSignature"><div dir=3D"ltr">TJ</div><=
div dir=3D"ltr"><br>Begin forwarded message:<br><br></div><blockquote type=3D=
"cite"><div dir=3D"ltr"><b>From:</b> Derek from Peptide Price &lt;derekprusk=
i@substack.com&gt;<br><b>Date:</b> March 16, 2026 at 10:25:49=E2=80=AFAM EDT=
<br><b>To:</b> tjphuhs@gmail.com<br><b>Subject:</b> <b>Nobody Lost 7 Pounds o=
f Fat in Their First Week on a GLP-1. Let's Talk About Why.</b><br><b>Reply-=
To:</b> Derek from Peptide Price &lt;reply+35so0v&amp;4iwoe6&amp;&amp;82edb6=
be5b009f85c0744544f02d4a5269faf369ed1e663207a198ec47c9f0d9@mg1.substack.com&=
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gb(0,0,0,.1);border-radius: 9999px;text-transform: uppercase;font-size: 12px=
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 middle;margin-right: 4px">READ IN APP</span><img class=3D"icon text-icon" s=
rc=3D"https://substackcdn.com/image/fetch/$s_!ET-_!,w_36,c_scale,f_png,q_aut=
o:good,fl_progressive:steep/https%3A%2F%2Fsubstack.com%2Ficon%2FLucideArrowU=
pRight%3Fv%3D4%26height%3D36%26fill%3Dnone%26stroke%3D%2523808080%26strokeWi=
dth%3D2" width=3D"18" height=3D"18" style=3D"min-width: 18px;min-height: 18p=
x;border: none;vertical-align: middle;margin-right: 0;margin-left: 0;max-wid=
th: 18px" alt=3D"" data-unique-identifier=3D""></a></td></tr></tbody></table=
></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr height=3D=
"16"><td height=3D"16" style=3D"font-size:0px;line-height:0;">&nbsp;</td></t=
r></tbody></table></div></div><div class=3D"post typography" dir=3D"auto" st=
yle=3D"--image-offset-margin: -120px;padding: 32px 0 0 0;font-size: 16px;lin=
e-height: 26px;"><div class=3D"body markup" dir=3D"auto" style=3D"text-align=
: initial;font-size: 16px;line-height: 26px;width: 100%;word-break: break-wo=
rd;margin-bottom: 16px;"><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55)=
;line-height: 26px;font-size: 16px;margin-top: 0;"><em>Research &amp; Educat=
ional Content Only =E2=80=94 Not Medical Advice</em></p><div style=3D"font-s=
ize: 16px;line-height: 26px;"><hr style=3D"margin: 32px 0;padding: 0;height:=
 1px;background: rgb(0,0,0,.1);border: none;"></div><p style=3D"margin: 0 0 2=
0px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">This is a ran=
t, and it=E2=80=99s a necessary one.</p><p style=3D"margin: 0 0 20px 0;color=
: rgb(54,55,55);line-height: 26px;font-size: 16px;">Social media is full of p=
eople claiming they lost 7, 8, even 10 pounds in their first week on a GLP-1=
. And on the flip side, people who stopped their GLP-1 and claim they =E2=80=
=9Cgained 7 pounds of fat back=E2=80=9D in days. Both narratives are spreadi=
ng fast, and both are doing real damage to people who are quietly comparing t=
heir experience and wondering what=E2=80=99s wrong with them.</p><div class=3D=
"captioned-image-container-static" style=3D"font-size: 16px;line-height: 26p=
x;margin: 32px auto;"><figure style=3D"width: 100%;margin: 0 auto;"><table c=
lass=3D"image-wrapper" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpad=
ding=3D"0" data-component-name=3D"Image2ToDOMStatic" style=3D"mso-padding-al=
t: 1em 0 1.6em;"><tbody><tr><td style=3D"text-align: center;"></td><td class=
=3D"content" align=3D"left" width=3D"1456" style=3D"text-align: center;"><a c=
lass=3D"image-link" target=3D"_blank" href=3D"https://substack.com/redirect/=
e6dea80e-95b8-4234-943f-fccac8ac7e07?j=3DeyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfd=
amY0krRXGMy3p768BWtuZifRB-Zs" rel=3D"" style=3D"position: relative;flex-dire=
ction: column;align-items: center;padding: 0;width: auto;height: auto;border=
: none;text-decoration: none;display: block;margin: 0;"><img class=3D"wide-i=
mage" data-attrs=3D"{&quot;src&quot;:&quot;https://substack-post-media.s3.am=
azonaws.com/public/images/be649466-ce84-4c20-8cc3-9d57bb020507_1536x1024.png=
&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;ima=
geSize&quot;:null,&quot;height&quot;:971,&quot;width&quot;:1456,&quot;resize=
Width&quot;:null,&quot;bytes&quot;:2731116,&quot;alt&quot;:null,&quot;title&=
quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quo=
t;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&=
quot;:&quot;https://derekpruski.substack.com/i/191134111?img=3Dhttps%3A%2F%2=
Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbe649466-ce84-4c20=
-8cc3-9d57bb020507_1536x1024.png&quot;,&quot;isProcessing&quot;:false,&quot;=
align&quot;:null,&quot;offset&quot;:false}" alt=3D"" width=3D"550" height=3D=
"366.7925824175824" src=3D"https://substackcdn.com/image/fetch/$s_!TNxJ!,w_1=
100,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-p=
ost-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbe649466-ce84-4c20-8cc3-9d57b=
b020507_1536x1024.png" style=3D"border: none !important;vertical-align: midd=
le;display: block;-ms-interpolation-mode: bicubic;height: auto;margin-bottom=
: 0;width: auto !important;max-width: 100% !important;margin: 0 auto;" data-=
unique-identifier=3D""></a></td><td style=3D"text-align: center;"></td></tr>=
</tbody></table></figure></div><p style=3D"margin: 0 0 20px 0;color: rgb(54,=
55,55);line-height: 26px;font-size: 16px;">Nothing is wrong with them. The s=
cale is just lying, and nobody is explaining why.</p><p style=3D"margin: 0 0=
 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">Let=E2=80=99=
s fix that.</p><div class=3D"subscribe-widget is-signed-up" data-component-n=
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e=3D"text-decoration: unset;list-style: none;font-size: 16px;line-height: 26=
px;text-align: center;cursor: pointer;border-radius: 4px;"><a class=3D"butto=
n subscribe-btn primary" href=3D"https://substack.com/redirect/2/eyJlIjoiaHR=
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1dG1fY2FtcGFpZ249ZW1haWwtY2hlY2tvdXQmbmV4dD1odHRwcyUzQSUyRiUyRmRlcmVrcHJ1c2t=
pLnN1YnN0YWNrLmNvbSUyRnAlMkZub2JvZHktbG9zdC03LXBvdW5kcy1vZi1mYXQtaW4tdGhlaXI=
mcj00aXdvZTYmdG9rZW49ZXlKMWMyVnlYMmxrSWpveU56TTJNakl6T1Rnc0ltbGhkQ0k2TVRjM01=
6WTNNVEUwT0N3aVpYaHdJam94TnpjMk1qWXpNVFE0TENKcGMzTWlPaUp3ZFdJdE16TTJOVE0yTnl=
Jc0luTjFZaUk2SW1Ob1pXTnJiM1YwSW4wLkw3blRCWGpMN2Z1U1VmLWUxWEE5RlU2OVBvUXFHcV9=
0aFpnOHdOQkVLa2MiLCJwIjoxOTExMzQxMTEsInMiOjMzNjUzNjcsImYiOnRydWUsInUiOjI3MzY=
yMjM5OCwiaWF0IjoxNzczNjcxMTQ4LCJleHAiOjIwODkyNDcxNDgsImlzcyI6InB1Yi0wIiwic3V=
iIjoibGluay1yZWRpcmVjdCJ9.wSPmig9D-ZPllPEBHxPPqPn90iPqj5cyhTMF85eBnIU?&amp;u=
tm_medium=3Demail&amp;utm_source=3Dsubscribe-widget&amp;utm_content=3D191134=
111" style=3D"font-family: system-ui,-apple-system,BlinkMacSystemFont,'Segoe=
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'Segoe UI Symbol';display: inline-block;box-sizing: border-box;cursor: point=
er;border: none;border-radius: 8px;font-size: 14px;line-height: 20px;font-we=
ight: 600;text-align: center;opacity: 1;outline: none;white-space: nowrap;te=
xt-decoration: none !important;margin: 0 auto;background-color: #FF6719;colo=
r: #ffffff !important;padding: 12px 20px;height: auto;"><span style=3D"color=
: #ffffff;text-decoration: none;">Upgrade to paid</span></a></div></div><div=
 style=3D"font-size: 16px;line-height: 26px;"><hr style=3D"margin: 32px 0;pa=
dding: 0;height: 1px;background: rgb(0,0,0,.1);border: none;"></div><p style=
=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16p=
x;"><strong>You Cannot Lose 7 Pounds of Fat in a Week</strong></p><p style=3D=
"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;"=
>To lose one pound of actual body fat, you need to burn roughly 3,500 calori=
es more than you consume. To lose 7 pounds of fat in 7 days, you=E2=80=99d n=
eed a 24,500 calorie deficit in a single week =E2=80=94 that=E2=80=99s 3,500=
 calories per day. Unless something truly extraordinary is happening, that n=
umber is physiologically impossible for the vast majority of people.</p><p s=
tyle=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size:=
 16px;">So what is actually happening on that scale? Water. Almost entirely w=
ater.</p><div style=3D"font-size: 16px;line-height: 26px;"><hr style=3D"marg=
in: 32px 0;padding: 0;height: 1px;background: rgb(0,0,0,.1);border: none;"><=
/div><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;f=
ont-size: 16px;"><strong>The Carb-Water Connection Most People Don=E2=80=99t=
 Know About</strong></p><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);=
line-height: 26px;font-size: 16px;"><span>Here=E2=80=99s the piece of educat=
ion that changes everything. Your body stores carbohydrates as glycogen =E2=80=
=94 essentially a fuel reserve kept in your muscles and liver for quick ener=
gy. The critical detail is that glycogen does not store alone. Glycogen is s=
tored in the liver, muscles, and fat cells in hydrated form =E2=80=94 three t=
o four parts water for every part glycogen. </span><a href=3D"https://substa=
ck.com/redirect/8cb1b6cd-8396-4d0d-bdce-577f45c8b6ff?j=3DeyJ1IjoiNGl3b2U2In0=
.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs" rel=3D"" style=3D"color: #ff67=
19;text-decoration: none;">PubMed</a></p><p style=3D"margin: 0 0 20px 0;colo=
r: rgb(54,55,55);line-height: 26px;font-size: 16px;"><span>What that means i=
n plain English: for every gram of carbohydrate your body stores as fuel, it=
 holds onto roughly 3-4 grams of water alongside it. Each gram of glycogen i=
s associated with 3-4 grams of water. As your body burns through reduced die=
tary carbs and into glycogen stores, the water attached to the glycogen is l=
ost as well =E2=80=94 resulting in what=E2=80=99s commonly known as losing w=
ater weight. There=E2=80=99s no fat loss here yet. </span><a href=3D"https:/=
/substack.com/redirect/9276e821-c644-497c-8c01-7770122d9112?j=3DeyJ1IjoiNGl3=
b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs" rel=3D"" style=3D"color=
: #ff6719;text-decoration: none;">8fit</a></p><p style=3D"margin: 0 0 20px 0=
;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">Run the math on so=
meone eating a normal diet. The average person stores several hundred grams o=
f glycogen at any given time. At a 3-4:1 water ratio, that=E2=80=99s easily 3=
-7 pounds of water weight sitting in your body right now =E2=80=94 just from=
 carbohydrate storage alone. Add sodium into the mix, which also causes your=
 body to retain fluid, and the swings get even larger.</p><div style=3D"font=
-size: 16px;line-height: 26px;"><hr style=3D"margin: 32px 0;padding: 0;heigh=
t: 1px;background: rgb(0,0,0,.1);border: none;"></div><p style=3D"margin: 0 0=
 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;"><strong>Wha=
t Actually Happens When Someone Starts a GLP-1</strong></p><p style=3D"margi=
n: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">GLP-1=
 compounds work by suppressing appetite, slowing gastric emptying, and impro=
ving insulin sensitivity. The appetite suppression in particular is real and=
 meaningful =E2=80=94 most people naturally and significantly reduce how muc=
h food they=E2=80=99re eating, often without even trying.</p><p style=3D"mar=
gin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">Her=
e=E2=80=99s where it gets interesting. When someone starts a GLP-1 and their=
 appetite drops dramatically, a few things tend to happen at the same time:<=
/p><ul style=3D"margin-top: 0;padding: 0;"><li style=3D"margin: 8px 0 0 32px=
;mso-special-format: bullet;"><p style=3D"color: rgb(54,55,55);line-height: 2=
6px;margin-bottom: 0;box-sizing: border-box;padding-left: 4px;font-size: 16p=
x;margin: 0;">Carbohydrate intake drops significantly because they=E2=80=99r=
e eating less overall</p></li><li style=3D"margin: 8px 0 0 32px;mso-special-=
format: bullet;"><p style=3D"color: rgb(54,55,55);line-height: 26px;margin-b=
ottom: 0;box-sizing: border-box;padding-left: 4px;font-size: 16px;margin: 0;=
">Sodium intake drops because they=E2=80=99re eating fewer processed foods a=
nd restaurant meals</p></li><li style=3D"margin: 8px 0 0 32px;mso-special-fo=
rmat: bullet;"><p style=3D"color: rgb(54,55,55);line-height: 26px;margin-bot=
tom: 0;box-sizing: border-box;padding-left: 4px;font-size: 16px;margin: 0;">=
Total food volume decreases, meaning less food mass sitting in the digestive=
 system</p></li></ul><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);lin=
e-height: 26px;font-size: 16px;"><span>Every single one of those things caus=
es the scale to drop =E2=80=94 fast =E2=80=94 and none of it is fat. It=E2=80=
=99s glycogen being depleted and the water leaving with it. It=E2=80=99s sod=
ium dropping and fluid following. Glycogen losses are associated with an add=
itional three to four parts water, meaning as much as 5 kg of weight change m=
ight not be associated with any fat loss at all. </span><a href=3D"https://s=
ubstack.com/redirect/8cb1b6cd-8396-4d0d-bdce-577f45c8b6ff?j=3DeyJ1IjoiNGl3b2=
U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs" rel=3D"" style=3D"color: #=
ff6719;text-decoration: none;">PubMed</a></p><p style=3D"margin: 0 0 20px 0;=
color: rgb(54,55,55);line-height: 26px;font-size: 16px;">That=E2=80=99s over=
 11 pounds of potential scale movement that has absolutely nothing to do wit=
h body fat.</p><div style=3D"font-size: 16px;line-height: 26px;"><hr style=3D=
"margin: 32px 0;padding: 0;height: 1px;background: rgb(0,0,0,.1);border: non=
e;"></div><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 2=
6px;font-size: 16px;"><strong>The Same Thing Happens in Reverse</strong></p>=
<p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-s=
ize: 16px;">Anyone who has done serious cutting and bulking phases in the gy=
m already knows this intuitively. When you come off a cut and start eating m=
ore =E2=80=94 especially more carbs and sodium =E2=80=94 the scale jumps fas=
t. A 5-7 pound swing in a matter of days is completely normal and expected. I=
t doesn=E2=80=99t mean you gained fat. It means your glycogen stores refille=
d and brought water back with them.</p><p style=3D"margin: 0 0 20px 0;color:=
 rgb(54,55,55);line-height: 26px;font-size: 16px;">The same thing happens wh=
en someone stops a GLP-1. Their appetite returns, food intake increases, car=
bs and sodium go back up, and glycogen refills. The scale goes up 5-7 pounds=
 in a week and social media screams that they =E2=80=9Cgained all the fat ba=
ck.=E2=80=9D They didn=E2=80=99t. Their body just rehydrated.</p><p style=3D=
"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;"=
>Actual fat regain takes weeks and months of caloric surplus =E2=80=94 not d=
ays.</p><div style=3D"font-size: 16px;line-height: 26px;"><hr style=3D"margi=
n: 32px 0;padding: 0;height: 1px;background: rgb(0,0,0,.1);border: none;"></=
div><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;fo=
nt-size: 16px;"><strong>So Does Any of This Mean GLP-1s Don=E2=80=99t Work?<=
/strong></p><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height:=
 26px;font-size: 16px;">Absolutely not. GLP-1 compounds are well-researched a=
nd the fat loss over time is real and meaningful. The appetite suppression i=
s genuine, the metabolic effects are genuine, and for many researchers the l=
ong-term results are significant. The point isn=E2=80=99t to discredit the c=
ompounds =E2=80=94 it=E2=80=99s to set realistic expectations so people don=E2=
=80=99t get discouraged when their first week looks different from someone e=
lse=E2=80=99s highlight reel.</p><div style=3D"font-size: 16px;line-height: 2=
6px;"><hr style=3D"margin: 32px 0;padding: 0;height: 1px;background: rgb(0,0=
,0,.1);border: none;"></div><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,=
55);line-height: 26px;font-size: 16px;"><strong>Stop Comparing Your Research=
 Journey</strong></p><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);lin=
e-height: 26px;font-size: 16px;">This is the bottom line. Social media rewar=
ds dramatic results and big numbers. Nobody posts =E2=80=9CI lost 1.2 pounds=
 this week, which is probably mostly fat.=E2=80=9D They post the week they d=
ropped 8 pounds of water and call it a transformation.</p><p style=3D"margin=
: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">Your p=
rotocol is yours. Your starting point, your carb intake, your sodium habits,=
 your hydration =E2=80=94 all of it is different from the person you=E2=80=99=
re comparing yourself to. A slower start on the scale doesn=E2=80=99t mean t=
he compound isn=E2=80=99t working. It might just mean your body was already r=
easonably hydrated and your diet was already reasonably clean.</p><p style=3D=
"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;"=
>Trust the process, give it time, and ignore the noise.</p><div style=3D"fon=
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