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From: Hunter Williams <huntershealthhacks@mail.beehiiv.com>
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Subject: Spermidine, NAD+, and Longevity
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Happy Wednesday!=20

Over the past few weeks, I=E2=80=99ve gone deep down the rabbit hole on spe=
rmidine.

Spermidine has been around for a while.

It is a naturally occurring polyamine found in foods such as wheat germ, mu=
shrooms, soybeans, and aged cheese.

It also exists within every cell in our body, and like most things, endogen=
ous levels decline with age.=20

In animal models, spermidine consistently extends lifespan.=20

I=E2=80=99ve been adding it to my supplement stack recently and have seen n=
oticeable improvements in my energy levels.

If you=E2=80=99re serious about longevity signaling, mitochondrial health, =
and building a non-disease-favoring internal environment, spermidine deserv=
es your attention.

Let=E2=80=99s break it down.

=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
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=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94

**How Spermidine Works**

Spermidine=E2=80=99s primary claim to fame is its ability to activate autop=
hagy.

Autophagy is the cellular cleanup process. It=E2=80=99s how your cells remo=
ve damaged proteins, dysfunctional mitochondria, and cellular debris. It is=
 one of the most consistently associated mechanisms with lifespan extension=
 across species.

Spermidine induces autophagy independent of direct mTOR inhibition.=20

Instead, one of its major actions is the inhibition of EP300 acetyltransfer=
ase.=20

EP300 promotes protein acetylation, which suppresses autophagy. By inhibiti=
ng EP300, spermidine deacetylates key autophagy proteins, turning the clean=
up machinery back on.

It also enhances mitophagy, the removal of damaged mitochondria. That impro=
ves mitochondrial efficiency, reduces reactive oxygen species, and lowers i=
nflammatory signaling.

Essentially, it is a cellular quality control enhancer.

=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
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=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94

**Benefits and Clinical Efficacy**

In worms and flies, spermidine increases lifespan by roughly 10-30%.=20

In mice, dietary supplementation improves median lifespan, reduces cardiac =
hypertrophy, preserves diastolic function, and reduces fibrosis.

Cardiovascular protection is one of the strongest themes in the literature.=
 In aged mice, spermidine improves endothelial function, lowers blood press=
ure, and preserves mitochondrial integrity in heart tissue.

Now, what about humans?

We do not yet have massive lifespan trials. But we do have epidemiological =
data linking higher dietary intake of spermidine to reduced cardiovascular =
and all-cause mortality.=20

We also have small randomized controlled trials in older adults showing spe=
rmidine-rich extracts are safe and well-tolerated, with some cognitive bene=
fits in specific subgroups.

=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
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=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94

**How Spermidine Could Support Exogenous NAD+ Supplementation**

This is where it gets interesting.

NAD+ is metabolic fuel.=20

It drives sirtuins, supports mitochondrial respiration, and assists DNA rep=
air. When you supplement with exogenous NAD+ or high-dose precursors like N=
MN, you increase substrate availability.

But here is the problem.

If your mitochondria are dysfunctional, you are pouring premium fuel into a=
 dirty engine.

Spermidine enhances mitophagy. It improves mitochondrial quality control. I=
t reduces oxidative stress and potentially lowers chronic NAD+ consumption =
by inhibiting PARP activation driven by ongoing DNA damage.

Sirtuins require NAD+. Spermidine activates downstream SIRT1 pathways in an=
imal models.=20

In simple terms, NAD+ provides the fuel and spermidine enhances the signali=
ng response.

They are complementary.

Spermidine does not raise NAD+ levels directly and is not a precursor.=20

But it does improve NAD+ efficiency and cellular resilience so that the NAD=
+ you are using actually produces meaningful longevity signaling.

If you are using exogenous NAD+, adding spermidine makes mechanistic sense.

=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
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=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94

**Dosage **

Human trials have used a wide range of doses.

Some plant-extract studies are in the 1-1.2 mg/day range. There are safety =
studies in healthy older adults at 40 mg/day showing good tolerability. The=
re are pharmacokinetic studies at 15 mg/day.

Based on mechanistic reasoning and available human safety data, my personal=
 sweet spot is 5-10 mg per day.

At that dose, you are above dietary intake levels but well within studied s=
afety margins.=20

You are likely achieving meaningful autophagy signaling without going into =
experimental megadosing territory.

This is not something I would pulse. I view spermidine as a consistent back=
ground longevity signal. Think of it more like mitochondrial maintenance th=
an an acute intervention.

If you are fasting aggressively, using rapamycin, or running strong autopha=
gy-inducing stacks already, it may be somewhat redundant.

But if you are simply lifting, eating clean, and supplementing NAD+, this i=
s a smart addition.

=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
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=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94

**Where I Get My Spermidine**

Polyamines are sensitive compounds, and quality matters. I want purity, sta=
bility, and proper dosing transparency.

I get mine from NAD Regen through BioStack Labs.

You can access it here:

[http://biostacklabs.com/hunter](https://biostacklabs.com/hunter)

I=E2=80=99ve had great experiences with it, and it contains a few other ing=
redients synergize with spermidine to enhance its effects.=20

If you=E2=80=99re going to invest in NAD+, make sure you=E2=80=99re not pou=
ring it into broken mitochondria.

Fix the engine first, optimize mitochondrial quality control, and stop wast=
ing your cellular currency!=20

Best,

Hunter Williams

=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94

**Further Reading**

Here are several primary sources if you want to dig deeper:

* [https://www.nature.com/articles/nm.4222](https://www.nature.com/articles=
/nm.4222)

* [https://pubmed.ncbi.nlm.nih.gov/29955838](https://pubmed.ncbi.nlm.nih.go=
v/29955838/)

* [https://pubmed.ncbi.nlm.nih.gov/30388439](https://pubmed.ncbi.nlm.nih.go=
v/30388439/)

* [https://pubmed.ncbi.nlm.nih.gov/29371440/](https://pubmed.ncbi.nlm.nih.g=
ov/29371440/)

* [https://pubmed.ncbi.nlm.nih.gov/29315079/](https://pubmed.ncbi.nlm.nih.g=
ov/29315079/)



=E2=80=94=E2=80=94=E2=80=94

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body class=3D"a" style=3D"margin:0px auto;padding:0px;word-wrap:normal;word=
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escription=3D"email" aria-label=3D"email_name" lang=3D"en" style=3D"font-si=
ze:1rem"><div style=3D"display:none;max-height:0px;overflow:hidden;"> Don&#=
39;t waste your NAD+! &#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&=
#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#820=
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 border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td =
class=3D"f" align=3D"right" valign=3D"top"><p> February 25, 2026 &nbsp; | &=
nbsp; <a href=3D"https://link.mail.beehiiv.com/ss/c/u001.KRi0pFg1TnB-L5Xr4V=
THbTUXhpH0c4aibrubwMtxLGEIUaSv5HtWd5ujPkVIrtS2tnMWgOQxLbySN0kl-x_HM8g0NK5vJ=
YA0Kn2CDVeP9JC26o-n6U3UTD2GkqJlEmY2cyyiUo2xq3xbvxEjbYYpPCq5YSY45TN6w_2bE42-=
UQy0hDbjlbe6HIpWkA1XBHcxkvGy9NSRF9LX2_1Eb6VNNe3S-b0qFSKADhWni8-8PNyQSoZT3QK=
ByMMnjy0H7VlXruI5DuFWCsAUAY3ryTQ3VzWZcATiLLSIJNy9spFRiF3YouSkGpaCAHGUXNZw6-=
_clweNoFv5QgZeNvIQT6qrPySOHDsfETd4kyjQJi22QHO1H2HtthK0xhkgcQg1Du5rn7a8svZ6d=
98VSAC9T6bwLexMs1TZQ0tsH2op07k0P6Szi9-RzVZ0urDZ8CEeUx9AlBFwoKazU3uSqa_Zt0is=
ogaeK9-VNdR-I07--wdxNOKQ89BrCGDUxMQC_i-XKDEKnHryRW6jWq5zV1se7wqbDUWQgRuoB2i=
ui6YK0q_A4pzzIkRIp3m870qULAvf1zILAw5BgmGtG8-pArI2A_XFPhfstldgSWGxOSYr1nDOVw=
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header.read_online">Read Online</span></a></p></td></tr><tr><td class=3D"dd=
" align=3D"center" valign=3D"top" style=3D"padding:15px 0;"><table role=3D"=
none" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=
=3D"center"><tr><td align=3D"center" valign=3D"top"><h1 style=3D"text-align=
:left;font-family:'Trebuchet MS','Lucida Grande',Tahoma,sans-serif;font-wei=
ght:Bold;font-size:32px;color:#2A2A2A;padding:2px 0;line-height:38px;"> Spe=
rmidine, NAD+, and Longevity </h1><p style=3D"text-align:left;font-family:'=
Helvetica',Arial,sans-serif;font-weight:normal;font-size:20px;color:#3E3E3E=
;padding:5px 0;line-height:24px;"> Don&#39;t waste your NAD+! </p></td></tr=
></table></td></tr><tr><td align=3D"center" valign=3D"top" class=3D"dd"><ta=
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align=3D"center" valign=3D"middle"><a href=3D"https://link.mail.beehiiv.com=
/ss/c/u001.fw6KhFr6V_IfF6b8t1O5ckqsEQXxy1v_4uKeAt_RbthiNPHfyXjVzQm18hqDOQb8=
aRPosXzjv2F9b8uEzXxFptwHa918sG4YVoZBluaSoBgoYGB8w7gB_wRPnFyallUCEhzpR0-BEme=
iycsbjmNUC32fHjBt0ZkT6Sq5KRKepNRQqQba4wQtvIreCsX-TebcllUyDUnCE1Ryv-mMnZI46Z=
Tf90xfL4gls2KWrpOkH5yUlPNeujQkHlgwqFiXJpRzDUjt6R1bMwb44O2pgL_ppj1HldO1YCZYt=
ycgLtdlI0VPb264x9rb96AtG48PE74iDVC0K9IhPY0DKfbl992kPfhg_rY9s1skyTJGTjidgDJp=
QgN50uh37nHv6KuZyOnr7gpxvz9FU-ho7ytB9VohPPkhZVI65hDLtSydv7EKmrg/4og/qHX3SIY=
ZQLKiy-AGcWTRMQ/h3/h001.AX7HBPW2zf3AbWl0af-z6lUpNZv7FkpvPC4JSbzY-aM" style=
=3D"text-decoration:none; display:block;"><table role=3D"none" border=3D"0"=
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er" valign=3D"middle" style=3D"border: 1px solid #E5E7EB; border-radius: 10=
0%; width: 18px; height: 18px; padding: 8px;"><img style=3D"display:block; =
width:100%; height:100%; max-width:18px; max-height:18px; object-fit: conta=
in;" alt=3D"share on threads" width=3D"18" height=3D"18" border=3D"0" src=
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onerror=3Dredirect,quality=3D80/static_assets/header/threads.png"/></td></t=
r></table></a></td><td width=3D"8" style=3D"width:8px;">&nbsp;</td><td alig=
n=3D"center" valign=3D"middle"><a href=3D"https://link.mail.beehiiv.com/ss/=
c/u001.fw6KhFr6V_IfF6b8t1O5cqLWyTPQA35UBCDAeDm2PWu31FN7unBuw2JgHciT5NNvyGvz=
1hIjqKFFsOFWKtxueac8EJfu4Unitfyzz8Z-5Qqscw9azu7KARAEh8q7VG_NwxSGkRDRJvGb9s5=
mqtkxiPchnXTy2IudPuDTljksgtprgWfiht2APM8HTCsRvtQEVOxVMQ0ogOugllEyCHrFAf7ySd=
YXGLzQC4IEnKyu3VgkALAEUsfWTy3y_-3lyjyA_oz9hH3b_BCPPW8kRDAdsJNkjO2NvBGd04Sfr=
DqBOSiLwqBYhFpSmEsQr7VYSHFnCIneFor9s9iBi1_3TuqScGsHvgaBXX_TQ16mWEAUMXvZlEFi=
lpdZXZr1IKzpYAHjAttprgoIhn7E-nOSKudd5Q/4og/qHX3SIYZQLKiy-AGcWTRMQ/h4/h001.p=
_HmqPm4Cyz59vvu5kBm1WHEfTWeufBUcKsSC2FFhMA" style=3D"text-decoration:none; =
display:block;"><table role=3D"none" border=3D"0" cellspacing=3D"0" cellpad=
ding=3D"0" align=3D"center"><tr><td align=3D"center" valign=3D"middle" styl=
e=3D"border: 1px solid #E5E7EB; border-radius: 100%; width: 18px; height: 1=
8px; padding: 8px;"><img style=3D"display:block; width:100%; height:100%; m=
ax-width:18px; max-height:18px; object-fit: contain;" alt=3D"share on linke=
din" width=3D"18" height=3D"18" border=3D"0" src=3D"https://media.beehiiv.c=
om/cdn-cgi/image/fit=3Dscale-down,format=3Dauto,onerror=3Dredirect,quality=
=3D80/static_assets/header/linkedin.png"/></td></tr></table></a></td></tr><=
/table></td></tr></table></td></tr></table></td></tr><tr><td style=3D"line-=
height:0;"><div data-open-tracking=3D"true"> <img src=3D"https://link.mail.=
beehiiv.com/ss/o/u001.U0NhyFVr9IdSaTRbqTkuyQ/4og/qHX3SIYZQLKiy-AGcWTRMQ/ho.=
gif" alt=3D"" width=3D"1" height=3D"1" border=3D"0" style=3D"height:1px !im=
portant;width:1px !important;border-width:0 !important;margin-top:0 !import=
ant;margin-bottom:0 !important;margin-right:0 !important;margin-left:0 !imp=
ortant;padding-top:0 !important;padding-bottom:0 !important;padding-right:0=
 !important;padding-left:0 !important;"/> </div></td></tr></table></div></t=
d></tr><tr id=3D"content-blocks"><td class=3D"email-card-body" align=3D"cen=
ter" valign=3D"top" style=3D"padding-bottom:px;"><table role=3D"none" width=
=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"=
><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:l=
eft;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span =
style=3D"font-size:1.5rem;">Happy Wednesday! </span></p></td></tr><tr><td c=
lass=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-b=
reak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"f=
ont-size:1.5rem;">Over the past few weeks, I=E2=80=99ve gone deep down the =
rabbit hole on spermidine.</span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
>Spermidine has been around for a while.</span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">It is a naturally occurring polyamine found in foods such as =
wheat germ, mushrooms, soybeans, and aged cheese.</span></p></td></tr><tr><=
td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wo=
rd-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">It also exists within every cell in our body, and li=
ke most things, endogenous levels decline with age. </span></p></td></tr><t=
r><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left=
;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span sty=
le=3D"font-size:1.5rem;">In animal models, spermidine consistently extends =
lifespan. </span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D=
"padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-l=
ine-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">I=E2=80=99ve been=
 adding it to my supplement stack recently and have seen noticeable improve=
ments in my energy levels.</span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
>If you=E2=80=99re serious about longevity signaling, mitochondrial health,=
 and building a non-disease-favoring internal environment, spermidine deser=
ves your attention.</span></p></td></tr><tr><td class=3D"dd" align=3D"left"=
 style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=
=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Let=E2=
=80=99s break it down.</span></p></td></tr><tr><td align=3D"center" valign=
=3D"top" style=3D"font-size:0px;line-height:0px;padding:30px 0px 30px;" cla=
ss=3D"dd"><table class=3D"j" role=3D"none" width=3D"50%" border=3D"0" cells=
pacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td> &nbsp; </td></tr><=
/table></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 1=
5px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt=
:150.0%;"><span style=3D"font-size:1.5rem;"><b>How Spermidine Works</b></sp=
an></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 1=
5px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt=
:150.0%;"><span style=3D"font-size:1.5rem;">Spermidine=E2=80=99s primary cl=
aim to fame is its ability to activate autophagy.</span></p></td></tr><tr><=
td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wo=
rd-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">Autophagy is the cellular cleanup process. It=E2=80=
=99s how your cells remove damaged proteins, dysfunctional mitochondria, an=
d cellular debris. It is one of the most consistently associated mechanisms=
 with lifespan extension across species.</span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">Spermidine induces autophagy independent of direct mTOR inhib=
ition. </span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"pa=
dding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-line=
-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Instead, one of its =
major actions is the inhibition of EP300 acetyltransferase. </span></p></td=
></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-al=
ign:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><=
span style=3D"font-size:1.5rem;">EP300 promotes protein acetylation, which =
suppresses autophagy. By inhibiting EP300, spermidine deacetylates key auto=
phagy proteins, turning the cleanup machinery back on.</span></p></td></tr>=
<tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:le=
ft;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span s=
tyle=3D"font-size:1.5rem;">It also enhances mitophagy, the removal of damag=
ed mitochondria. That improves mitochondrial efficiency, reduces reactive o=
xygen species, and lowers inflammatory signaling.</span></p></td></tr><tr><=
td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wo=
rd-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">Essentially, it is a cellular quality control enhanc=
er.</span></p></td></tr><tr><td align=3D"center" valign=3D"top" style=3D"fo=
nt-size:0px;line-height:0px;padding:30px 0px 30px;" class=3D"dd"><table cla=
ss=3D"j" role=3D"none" width=3D"50%" border=3D"0" cellspacing=3D"0" cellpad=
ding=3D"0" align=3D"center"><tr><td> &nbsp; </td></tr></table></td></tr><tr=
><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;=
word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span styl=
e=3D"font-size:1.5rem;"><b>Benefits and Clinical Efficacy</b></span></p></t=
d></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-a=
lign:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;">=
<span style=3D"font-size:1.5rem;">In worms and flies, spermidine increases =
lifespan by roughly 10-30%. </span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
>In mice, dietary supplementation improves median lifespan, reduces cardiac=
 hypertrophy, preserves diastolic function, and reduces fibrosis.</span></p=
></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;te=
xt-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0=
%;"><span style=3D"font-size:1.5rem;">Cardiovascular protection is one of t=
he strongest themes in the literature. In aged mice, spermidine improves en=
dothelial function, lowers blood pressure, and preserves mitochondrial inte=
grity in heart tissue.</span></p></td></tr><tr><td class=3D"dd" align=3D"le=
ft" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p st=
yle=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Now, =
what about humans?</span></p></td></tr><tr><td class=3D"dd" align=3D"left" =
style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=
=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">We do no=
t yet have massive lifespan trials. But we do have epidemiological data lin=
king higher dietary intake of spermidine to reduced cardiovascular and all-=
cause mortality. </span></p></td></tr><tr><td class=3D"dd" align=3D"left" s=
tyle=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=
=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">We also =
have small randomized controlled trials in older adults showing spermidine-=
rich extracts are safe and well-tolerated, with some cognitive benefits in =
specific subgroups.</span></p></td></tr><tr><td align=3D"center" valign=3D"=
top" style=3D"font-size:0px;line-height:0px;padding:30px 0px 30px;" class=
=3D"dd"><table class=3D"j" role=3D"none" width=3D"50%" border=3D"0" cellspa=
cing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td> &nbsp; </td></tr></t=
able></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15p=
x;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:1=
50.0%;"><span style=3D"font-size:1.5rem;"><b>How Spermidine Could Support E=
xogenous NAD+ Supplementation</b></span></p></td></tr><tr><td class=3D"dd" =
align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-w=
ord;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5=
rem;">This is where it gets interesting.</span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">NAD+ is metabolic fuel. </span></p></td></tr><tr><td class=3D=
"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:br=
eak-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-siz=
e:1.5rem;">It drives sirtuins, supports mitochondrial respiration, and assi=
sts DNA repair. When you supplement with exogenous NAD+ or high-dose precur=
sors like NMN, you increase substrate availability.</span></p></td></tr><tr=
><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;=
word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span styl=
e=3D"font-size:1.5rem;">But here is the problem.</span></p></td></tr><tr><t=
d class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wor=
d-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">If your mitochondria are dysfunctional, you are pour=
ing premium fuel into a dirty engine.</span></p></td></tr><tr><td class=3D"=
dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:bre=
ak-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size=
:1.5rem;">Spermidine enhances mitophagy. It improves mitochondrial quality =
control. It reduces oxidative stress and potentially lowers chronic NAD+ co=
nsumption by inhibiting PARP activation driven by ongoing DNA damage.</span=
></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15p=
x;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:1=
50.0%;"><span style=3D"font-size:1.5rem;">Sirtuins require NAD+. Spermidine=
 activates downstream SIRT1 pathways in animal models. </span></p></td></tr=
><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:l=
eft;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span =
style=3D"font-size:1.5rem;">In simple terms, NAD+ provides the fuel and spe=
rmidine enhances the signaling response.</span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">They are complementary.</span></p></td></tr><tr><td class=3D"=
dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:bre=
ak-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size=
:1.5rem;">Spermidine does not raise NAD+ levels directly and is not a precu=
rsor. </span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"pad=
ding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-line-=
height-alt:150.0%;"><span style=3D"font-size:1.5rem;">But it does improve N=
AD+ efficiency and cellular resilience so that the NAD+ you are using actua=
lly produces meaningful longevity signaling.</span></p></td></tr><tr><td cl=
ass=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-br=
eak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"fo=
nt-size:1.5rem;">If you are using exogenous NAD+, adding spermidine makes m=
echanistic sense.</span></p></td></tr><tr><td align=3D"center" valign=3D"to=
p" style=3D"font-size:0px;line-height:0px;padding:30px 0px 30px;" class=3D"=
dd"><table class=3D"j" role=3D"none" width=3D"50%" border=3D"0" cellspacing=
=3D"0" cellpadding=3D"0" align=3D"center"><tr><td> &nbsp; </td></tr></table=
></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;te=
xt-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0=
%;"><span style=3D"font-size:1.5rem;"><b>Dosage </b></span></p></td></tr><t=
r><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left=
;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span sty=
le=3D"font-size:1.5rem;">Human trials have used a wide range of doses.</spa=
n></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15=
px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:=
150.0%;"><span style=3D"font-size:1.5rem;">Some plant-extract studies are i=
n the 1-1.2 mg/day range. There are safety studies in healthy older adults =
at 40 mg/day showing good tolerability. There are pharmacokinetic studies a=
t 15 mg/day.</span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=
=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"ms=
o-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Based on mecha=
nistic reasoning and available human safety data, my personal sweet spot is=
 5-10 mg per day.</span></p></td></tr><tr><td class=3D"dd" align=3D"left" s=
tyle=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=
=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">At that =
dose, you are above dietary intake levels but well within studied safety ma=
rgins. </span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"pa=
dding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-line=
-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">You are likely achie=
ving meaningful autophagy signaling without going into experimental megados=
ing territory.</span></p></td></tr><tr><td class=3D"dd" align=3D"left" styl=
e=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"m=
so-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">This is not s=
omething I would pulse. I view spermidine as a consistent background longev=
ity signal. Think of it more like mitochondrial maintenance than an acute i=
ntervention.</span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=
=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"ms=
o-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">If you are fas=
ting aggressively, using rapamycin, or running strong autophagy-inducing st=
acks already, it may be somewhat redundant.</span></p></td></tr><tr><td cla=
ss=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-bre=
ak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"fon=
t-size:1.5rem;">But if you are simply lifting, eating clean, and supplement=
ing NAD+, this is a smart addition.</span></p></td></tr><tr><td align=3D"ce=
nter" valign=3D"top" style=3D"font-size:0px;line-height:0px;padding:30px 0p=
x 30px;" class=3D"dd"><table class=3D"j" role=3D"none" width=3D"50%" border=
=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td> &nbsp;=
 </td></tr></table></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"p=
adding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-lin=
e-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"><b>Where I Get My S=
permidine</b></span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=
=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"ms=
o-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Polyamines are=
 sensitive compounds, and quality matters. I want purity, stability, and pr=
oper dosing transparency.</span></p></td></tr><tr><td class=3D"dd" align=3D=
"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p=
 style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">I =
get mine from NAD Regen through BioStack Labs.</span></p></td></tr><tr><td =
class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-=
break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"=
font-size:1.5rem;">You can access it here:</span></p></td></tr><tr><td clas=
s=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-brea=
k:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font=
-size:1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/ss/c=
/u001.XBXHqIRlWD2o7jctEk3rycEABHOQ_My8EYThg1jjqXPgzQV0ePhVOQdvrmYhRCG3MguWY=
Rnu-_SAr0KEANK4Gjp39j4v5U2_8CmUr7A9Nsz2nCAjVtiDJp9_IZKpDUdyWKd3zd5xpUzmJ9xZ=
wrtMFig_dxKhFfTy3XfXDK4t7sPJACdA6aC-QWUhz-RHVtkjT19hvWBd3IgISU6Mi3RbEGjvwA_=
I-ZxELc5EFn0gtSAujffOVEgTq96iGGxsFAlYtT1HUTYxtdlNioEchl7Xkw/4og/qHX3SIYZQLK=
iy-AGcWTRMQ/h5/h001.JaukguDzf6YO7YSPg9KvAdr8XztLdp5I1hr3EK0DD2M" target=3D"=
_blank" rel=3D"noopener noreferrer nofollow"><span>http://biostacklabs.com/=
hunter</span></a></span></p></td></tr><tr><td class=3D"dd" align=3D"left" s=
tyle=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=
=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">I=E2=80=
=99ve had great experiences with it, and it contains a few other ingredient=
s synergize with spermidine to enhance its effects. </span></p></td></tr><t=
r><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left=
;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span sty=
le=3D"font-size:1.5rem;">If you=E2=80=99re going to invest in NAD+, make su=
re you=E2=80=99re not pouring it into broken mitochondria.</span></p></td><=
/tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-alig=
n:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><sp=
an style=3D"font-size:1.5rem;">Fix the engine first, optimize mitochondrial=
 quality control, and stop wasting your cellular currency! </span></p></td>=
</tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-ali=
gn:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><s=
pan style=3D"font-size:1.5rem;">Best,</span></p></td></tr><tr><td class=3D"=
dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:bre=
ak-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size=
:1.5rem;">Hunter Williams</span></p></td></tr><tr><td align=3D"center" vali=
gn=3D"top" style=3D"font-size:0px;line-height:0px;padding:30px 0px 30px;" c=
lass=3D"dd"><table class=3D"j" role=3D"none" width=3D"50%" border=3D"0" cel=
lspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td> &nbsp; </td></tr=
></table></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px=
 15px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-a=
lt:150.0%;"><span style=3D"font-size:1.5rem;"><b>Further Reading</b></span>=
</p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px=
;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:15=
0.0%;"><span style=3D"font-size:1.5rem;">Here are several primary sources i=
f you want to dig deeper:</span></p></td></tr><tr><td style=3D"padding-bott=
om:12px;padding-left:37px;padding-right:27px;padding-top:12px;" class=3D"ee=
"><div style=3D"margin-left:0px;" class=3D"edm_outlooklist"><ul style=3D"fo=
nt-weight:normal;list-style-type:disc;margin-bottom:12px !important;margin-=
top:12px !important;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"=
><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-br=
eak:break-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" href=
=3D"https://link.mail.beehiiv.com/ss/c/u001.fw6KhFr6V_IfF6b8t1O5crDH8xfAXbi=
b6Knthc5GOHix6-JGQZ1BVopekTGFExiQeiwdAop1pfaWgz2o8KLI2bg_dtyfvMuFNZdNGYkHAC=
lHu2O0qC_BUlqM7WbqiJ__xH3ZcmrVjiMP02vVGoRzfVm3HaIiAaa1kYXc2piRT_CU1yK86NuvT=
Ng314lrVmzl9tThPqrJA12PMWQ2tPj1yV2Wg-FXf1JHMAruYttlEHzFgpSa112-6csuvausk_Sv=
MINJD4Zdavw-ZX7Y292ZpQ/4og/qHX3SIYZQLKiy-AGcWTRMQ/h6/h001.hRXFegEprWC0FS1gj=
x-jsxHyv8cgWSRkSFGO0BdT4k4" target=3D"_blank" rel=3D"noopener noreferrer no=
follow"><span>https://www.nature.com/articles/nm.4222</span></a></span></p>=
</li><li class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;p=
adding:0px;text-align:left;word-break:break-word;"><span style=3D"font-size=
:1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/ss/c/u001=
.JrjGzO4qfF9nLlI-eIWxpNPuksIbEW-RqOMB4lYO2jdQEddFLZgekH6I1L8BCHm4WjncnUHbjb=
0Fr3Cvife47ou2B-FjinDVo8gP75UWvJf4p25kJ6dVAQWS64FYmroZDWUOUfbyQVz-w1ngOiPfX=
o2Tn6-OnnyVIBb10WlZrLIuHogjxIrVyvsJMLdR2xizOx9LRAmpazb2Fe_XpiVyGRvWd5CpuM02=
gd3eT2fstOgQEJUEVkrauGdp7RdgY2Gvg0mzZeuAyZzqXYfy-f6cZA/4og/qHX3SIYZQLKiy-AG=
cWTRMQ/h7/h001.D5tdqIlqLPGNp_oA1Qn3LHWQb2coyDZiyGeea4Sd-sw" target=3D"_blan=
k" rel=3D"noopener noreferrer nofollow"><span>https://pubmed.ncbi.nlm.nih.g=
ov/29955838</span></a></span></p></li><li class=3D"listItem ultext"><p styl=
e=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-break:brea=
k-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https:=
//link.mail.beehiiv.com/ss/c/u001.JrjGzO4qfF9nLlI-eIWxpNPuksIbEW-RqOMB4lYO2=
jeXc9H5d7gSgoZHA77lD_Y2TrdFj6SjMIOi4uhR-NxIe0sXM4ech1kZgWU9UcUqxZPsDsun23oR=
uQDwHKudYdA9QqdcEBX-9FzdBzFBgff7NJrzpNzTCK3nmKELSZnLfHWWX_ORCrBiYdf6ZqqW_87=
WxfJYXW0ygJDoR1Ar65N-h-F-SgHtN4ij0eCEPZAo4cCxH7WDMVkg0v2dWLiE7SzlMgZx_g0dP1=
I5nCmRSZupwg/4og/qHX3SIYZQLKiy-AGcWTRMQ/h8/h001.O2NAfUJA0Ljgp0p7hQYD8VgAQ4I=
rFloISRQpGs_bEqs" target=3D"_blank" rel=3D"noopener noreferrer nofollow"><s=
pan>https://pubmed.ncbi.nlm.nih.gov/30388439</span></a></span></p></li><li =
class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0p=
x;text-align:left;word-break:break-word;"><span style=3D"font-size:1.5rem;"=
><a class=3D"link" href=3D"https://link.mail.beehiiv.com/ss/c/u001.JrjGzO4q=
fF9nLlI-eIWxpNPuksIbEW-RqOMB4lYO2je1rJB3zwZl5tOHgIYGRIyjsKMoKTfXms1Wu6Qvo-m=
M8qJmlvcwUG0sLDKGbThpe17Eso0xM8a_F2e_3ZpzJCSYpSpOu9nRSQf0oSvUPVBMRZq5w0TiqX=
qk4-1sECQAiAv2U-3b4M7rFCy0k4Ap6HqiJhJNwPSfKnhho3ZAAEtq74yVErVItrnbntinRU4ml=
OAq2C7yJJxo1rwMF9Wmhi8j2PKTduvLIBPSYlo1tJycPw/4og/qHX3SIYZQLKiy-AGcWTRMQ/h9=
/h001.AqIfFKWgFn_WFWu82_Ldl3VsDf_GZhiPGoX5D4EMJ1Q" target=3D"_blank" rel=3D=
"noopener noreferrer nofollow"><span>https://pubmed.ncbi.nlm.nih.gov/293714=
40/</span></a></span></p></li><li class=3D"listItem ultext"><p style=3D"mso=
-line-height-alt:150.0%;padding:0px;text-align:left;word-break:break-word;"=
><span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https://link.m=
ail.beehiiv.com/ss/c/u001.JrjGzO4qfF9nLlI-eIWxpNPuksIbEW-RqOMB4lYO2jcGUzKoL=
9mj9s7aN3zQdjL6e2xlljTmWZSGmPW7mWBFLTpwgG69CKGUvSu4ALvUllLE-22c7y6QRg8PayIY=
CpupLAuzlbPNcZZUF6dKlzY-8Z3HFDgenIXlLBNB9_UUWcj5FsvwsKkY2GE3GZzUHsn6TkUA3ZF=
qfdAFzHQElHRGNlJgWOrSSBRt7sNL-5dGwvTs2Paf8IpY2DHwFRNEVRFey-ymzdybHV2KlSkTtZ=
AOIw/4og/qHX3SIYZQLKiy-AGcWTRMQ/h10/h001.OKg8NMigvK376AXvDNQnf3baeeuWhvJuR-=
Yf9i39Xy0" target=3D"_blank" rel=3D"noopener noreferrer nofollow"><span>htt=
ps://pubmed.ncbi.nlm.nih.gov/29315079/</span></a></span><br></p></li></ul><=
/div></td></tr></table></td></tr></table></td></tr><tr><td align=3D"center"=
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g=3D"0" cellpadding=3D"0" align=3D"center"><tr><td><tr><td class=3D"b" alig=
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ole=3D"none" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0=
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t,quality=3D80/static_assets/youtube_light.png"/></a></td><td><span style=
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center" valign=3D"top" style=3D"padding-bottom:20px;padding-left:15px;paddi=
ng-right:15px;padding-top:20px; " class=3D"dd"><table role=3D"none" border=
=3D"0" cellspacing=3D"0" cellpadding=3D"0" style=3D"margin:0 auto 0 auto;">=
<tr><td align=3D"center" valign=3D"top" style=3D"width:189px;"><img src=3D"=
https://media.beehiiv.com/cdn-cgi/image/fit=3Dscale-down,format=3Dauto,oner=
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x 0px 0px;border-style:solid;border-width:0px 0px 0px 0px;box-sizing:border=
-box;border-color:#E5E7EB;" border=3D"0"/></td></tr></table></td></tr><tr><=
td id=3D"want-more-heres-how-you-can-work-wi" class=3D"dd" align=3D"center"=
 valign=3D"top" style=3D"color:#2A2A2A;font-weight:normal;padding:0px 15px;=
text-align:center;"><h2 style=3D"color:#2A2A2A;font-weight:normal;mso-line-=
height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Want more? Here=E2=80=
=99s how you can work with me:</span></h2></td></tr><tr><td id=3D"join-my-p=
rivate-coaching-group-the-" class=3D"dd" align=3D"left" valign=3D"top" styl=
e=3D"color:#2A2A2A;font-weight:normal;padding:0px 15px;text-align:left;"><h=
4 style=3D"color:#2A2A2A;font-weight:normal;mso-line-height-alt:112.5%;"><s=
pan style=3D"font-size:1.5rem;">=F0=9F=91=89Join my private coaching group,=
 The AXION Collective:</span></h4></td></tr><tr><td style=3D"padding-bottom=
:12px;padding-left:37px;padding-right:27px;padding-top:12px;" class=3D"ee">=
<div style=3D"margin-left:0px;" class=3D"edm_outlooklist"><ul style=3D"font=
-weight:normal;list-style-type:disc;margin-bottom:12px !important;margin-to=
p:12px !important;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><=
p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-brea=
k:break-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"=
https://link.mail.beehiiv.com/ss/c/u001.UjJbMIoVWSyy6fZtu6gv3xnGcH8KVDTA4C7=
1EJ0NMLLrZUNxWPxdE_i0Q1M4vkRbZlcTaMqLKuHYLNKXtPr_OYi7FUv9uokYVRuNd8G-XtutP7=
2G_rJP9aMjMvzQ62Ny8D5gFXywCfhR6_t6VAqqHMriCoJcnwKjosZI0OKRmO_pgGTWUY6kNpr0Z=
UG6RoHJ3XtniS_cHnWuD4JXnSRJI_egOhlQJRolosX2JfaMZJaN-YXlOrCLzkm_OArarMi3GMkR=
RpDcB79Kf03uXIEuQg/4og/qHX3SIYZQLKiy-AGcWTRMQ/h13/h001.8esJR83XXpIhOAooJEgS=
52hvbwiXLO2diwUUUn5pph8" target=3D"_blank" rel=3D"noopener noreferrer nofol=
low"><span>The AXION Collective</span></a></span></p></li></ul></div></td><=
/tr><tr><td id=3D"try-zeroats-the-worlds-first-sugarf" class=3D"dd" align=
=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:normal;padding:=
0px 15px;text-align:left;"><h4 style=3D"color:#2A2A2A;font-weight:normal;ms=
o-line-height-alt:112.5%;"><span style=3D"font-size:1.5rem;">=F0=9F=91=89Tr=
y Zeroats, the world=E2=80=99s first sugar-free, naturally flavored oatmeal=
:</span></h4></td></tr><tr><td style=3D"padding-bottom:12px;padding-left:37=
px;padding-right:27px;padding-top:12px;" class=3D"ee"><div style=3D"margin-=
left:0px;" class=3D"edm_outlooklist"><ul style=3D"font-weight:normal;list-s=
tyle-type:disc;margin-bottom:12px !important;margin-top:12px !important;pad=
ding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p style=3D"mso-line-h=
eight-alt:150.0%;padding:0px;text-align:left;word-break:break-word;"><span =
style=3D"font-size:1.5rem;">Store:=C2=A0</span><span style=3D"font-size:1.5=
rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/ss/c/u001.1w9=
CaH2HuNy0TNq9Sy-zLNDOfGm_GBShiKqqb5ThPjswlSnCE_TfPRB6P1P0axL4KDjmLj4I4liBak=
ZERkY1lJs0EQJ4dUSFSHtZhQdD4l2aOo4mKhqADiCmvb_E2qy2eBzxyc6CtxJGfeQ2rQVggUP2T=
coQ3B0QWzs5i5KTH1mHPS9LkHCmDOFoJvKMC0BjRlp516Fw7oh30HazpDzjOo5aOQs9QX-KHAgT=
rIPuLmhGEoFsSavtVEYd7DkxML1t/4og/qHX3SIYZQLKiy-AGcWTRMQ/h14/h001.mt8NgO4r8B=
6ycpr3Il1WYLaG4UZQJ4CQrgJABhK4MlY" target=3D"_blank" rel=3D"noopener norefe=
rrer nofollow"><span>https://zeroats.com/</span></a></span><span style=3D"f=
ont-size:1.5rem;">=C2=A0</span></p></li><li class=3D"listItem ultext"><p st=
yle=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-break:br=
eak-word;"><span style=3D"font-size:1.5rem;">Amazon:=C2=A0</span><span styl=
e=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv=
.com/ss/c/u001.nUelgRZhw0fncfhI-zrahlyK1_iW4gORuh_iEcvZviWy4LPI_HFehbXWAhgt=
A7yP21qnvM-yahiCI-vNqgLUF8I1PHM1ci2b0lG_JD5dcs9g-h5A4P9muo_C7hhYezVZXotvGDJ=
Pf5Q_O-mWrgywmnMIlizVzM7xFg8dZCUWZ9qFpAYBIGIrQdT3lfiFp1N7BQsVxfoyhznrzZkjOe=
O9az286J4RHYmSK-ZgLyCp7X8duptvrp054gqeAlKtpv71/4og/qHX3SIYZQLKiy-AGcWTRMQ/h=
15/h001.iDHjjRJVesxpKdB21VSTe-G72ZAkUmzPS1d9QUFUHpM" target=3D"_blank" rel=
=3D"noopener noreferrer nofollow"><span>https://a.co/d/2gq1zJ9</span></a></=
span></p></li></ul></div></td></tr><tr><td id=3D"link-to-all-my-old-videos"=
 class=3D"dd" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-wei=
ght:normal;padding:0px 15px;text-align:left;"><h4 style=3D"color:#2A2A2A;fo=
nt-weight:normal;mso-line-height-alt:112.5%;"><span style=3D"font-size:1.5r=
em;">=F0=9F=91=89</span><span style=3D"font-size:1.5rem;">Link To All My Ol=
d Videos:</span></h4></td></tr><tr><td style=3D"padding-bottom:12px;padding=
-left:37px;padding-right:27px;padding-top:12px;" class=3D"ee"><div style=3D=
"margin-left:0px;" class=3D"edm_outlooklist"><ul style=3D"font-weight:norma=
l;list-style-type:disc;margin-bottom:12px !important;margin-top:12px !impor=
tant;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p style=3D"ms=
o-line-height-alt:150.0%;padding:0px;text-align:left;word-break:break-word;=
"><span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https://link.=
mail.beehiiv.com/ss/c/u001.fw6KhFr6V_IfF6b8t1O5cpCIVGKzm6uRDaXwtdwgYlHeFoNB=
-B3n__5ACLgTG3E6KcLksYw0Un1JlpgXK6sbxksXD5Lm38nXGHwRj4UCUrkAXRY6sMpQM4V1pac=
LCTLqu80JscPwtm2hU1db2Uix2-QipMQojuAR-EEsf1sd0CgdWiixLPEZEPu1R8uB4-JT0XhrZ1=
S9s0b-YyjzVGAL5M49onSHO021nyBmQ5HGqbCKyFt-6g3JbAguA1fCsygnTOlRzvMMSPs_f_5IV=
NmmZjLoVeUA0P_Ad2s4MrX6NRlKATdQTJNXja7gR4iIqcWsWTZVHaD4km6f_Hve_-FqyrWf1fRv=
GP1FbvDgrI5A6zWe_dv1PkOoIfqOToVmsX1z/4og/qHX3SIYZQLKiy-AGcWTRMQ/h16/h001.0L=
vDqOMuvZXmJHqeQDQJS37DT6BQSCFiDQpfpA8bwY0" target=3D"_blank" rel=3D"noopene=
r noreferrer nofollow"><span>DropBox with all videos</span></a></span></p><=
/li></ul></div></td></tr><tr><td id=3D"link-to-all-my-old-videos" class=3D"=
dd" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:normal=
;padding:0px 15px;text-align:left;"><h4 style=3D"color:#2A2A2A;font-weight:=
normal;mso-line-height-alt:112.5%;"><span style=3D"font-size:1.5rem;">=F0=
=9F=91=89</span><span style=3D"font-size:1.5rem;">Audio Versions of All Vid=
eos:</span></h4></td></tr><tr><td style=3D"padding-bottom:12px;padding-left=
:37px;padding-right:27px;padding-top:12px;" class=3D"ee"><div style=3D"marg=
in-left:0px;" class=3D"edm_outlooklist"><ul style=3D"font-weight:normal;lis=
t-style-type:disc;margin-bottom:12px !important;margin-top:12px !important;=
padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p style=3D"mso-lin=
e-height-alt:150.0%;padding:0px;text-align:left;word-break:break-word;"><sp=
an style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https://link.mail.=
beehiiv.com/ss/c/u001.JrjGzO4qfF9nLlI-eIWxpH2-I2ZEOEuXtBWjQDV-sgcA7X3JGLaUV=
L20hBauq3RgWRfuIzpuU9XVdl4g6hFznZo9ikUcyIs088uEw3Cqmjm3RfhxpFcJ4yvrROtCRmtK=
2krkjFWkBJIUEGGVcrRPKZZjOOqgom8yF6KKwtpgS50SKiNRUU75Koh-7BOSwROstLLS1eQcrXd=
wEC-nb8LTevhojIoZNL3wd4MCnsDzJKyC8VbTqEi8v-N0D-S-sFGsrYe6uR5Nhu4qtOO_AxnrQw=
iN4fPLDc5Xw39fw45DIrCXGFgqCRxqgfdsrIqYqkAI/4og/qHX3SIYZQLKiy-AGcWTRMQ/h17/h=
001.RPcC8x-h-r8xeIJVj1Lsq9QJVtdufb1DhmUXwa7FTNg" target=3D"_blank" rel=3D"n=
oopener noreferrer nofollow"><span>Itunes</span></a></span></p></li><li cla=
ss=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;t=
ext-align:left;word-break:break-word;"><span style=3D"font-size:1.5rem;"><a=
 class=3D"link" href=3D"https://link.mail.beehiiv.com/ss/c/u001.8z62hi1uQ3T=
M4taX1dDvAhGlRHE1KNDjz9M5L2SJTUnkaMu-CnLUWB8qTtxWtSauEKVcsyFFaB9hkwstM9jnT9=
xoB9n5h7zwpOJ18e8_0Mvzpom4CS6tAHcJXY9TqGn8YtiaqOhoKzg-Gn-Kc912pdaUvdZv3v5yy=
6tTE1ormGselGFJAvbnLjpLcdQYr0CW71dWscsUEki4rB79gFvHwcb77zBTQ4i4Fjb0IQyEiHQU=
2HqsWYPCr2X0DJmq3Ok3K-5HZP1ULi0VVcKvJq0y4Tt2elfawWfmJXvO7h6oO-g/4og/qHX3SIY=
ZQLKiy-AGcWTRMQ/h18/h001.wf4nD7niOcNddnlZeKJ8VCw7strs_3QpncPbI-2iCPw" targe=
t=3D"_blank" rel=3D"noopener noreferrer nofollow"><span>Spotify</span></a><=
/span></p></li></ul></div></td></tr><tr><td id=3D"get-the-peptide-cheat-she=
et" class=3D"dd" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-=
weight:normal;padding:0px 15px;text-align:left;"><h3 style=3D"color:#2A2A2A=
;font-weight:normal;mso-line-height-alt:125.0%;"><span style=3D"font-size:1=
.5rem;">=F0=9F=91=89Get the Peptide Cheat Sheet:</span></h3></td></tr><tr><=
td style=3D"padding-bottom:12px;padding-left:37px;padding-right:27px;paddin=
g-top:12px;" class=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_outl=
ooklist"><ul style=3D"font-weight:normal;list-style-type:disc;margin-bottom=
:12px !important;margin-top:12px !important;padding:0px 0px 0px 0px;"><li c=
lass=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px=
;text-align:left;word-break:break-word;"><span style=3D"font-size:1.5rem;">=
<a class=3D"link" href=3D"https://link.mail.beehiiv.com/ss/c/u001.97tz9iG2F=
yt4lvKCE-s7rrZq_ShObZ8nl_CpGJXtrivCskgx5wO0iJI40ZvpP9ivR_nwfmiV4e-JFheEswy1=
hXRXm8DuKSOO_zOdPXwgThHqaq3Z_1e0NHrSsdPLodXcr3lDgKrWTv3nDcTzTflPO3n700M7iWI=
wW05kKrL3cUmsFg__vg9ku2tzgkBfwV3echW4Hy0plnbGYEkAiHrt1ASFZPaMsEY36h7j_E3sIa=
hADAhYSUPfX5QIR8kOPGP7/4og/qHX3SIYZQLKiy-AGcWTRMQ/h19/h001.ZDr53xFtUfAlu34i=
SpBCBiTtaczDAb0z4m29lL0uJaI" target=3D"_blank" rel=3D"noopener noreferrer n=
ofollow"><span>Peptide Cheat Sheet</span></a></span></p></li></ul></div></t=
d></tr><tr><td id=3D"all-my-daily-essentials-on-amazon" class=3D"dd" align=
=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:normal;padding:=
0px 15px;text-align:left;"><h3 style=3D"color:#2A2A2A;font-weight:normal;ms=
o-line-height-alt:125.0%;"><span style=3D"font-size:1.5rem;">=F0=9F=91=89Al=
l my daily essentials on Amazon</span></h3></td></tr><tr><td style=3D"paddi=
ng-bottom:12px;padding-left:37px;padding-right:27px;padding-top:12px;" clas=
s=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_outlooklist"><ul styl=
e=3D"font-weight:normal;list-style-type:disc;margin-bottom:12px !important;=
margin-top:12px !important;padding:0px 0px 0px 0px;"><li class=3D"listItem =
ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;=
word-break:break-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link"=
 href=3D"https://link.mail.beehiiv.com/ss/c/u001.fw6KhFr6V_IfF6b8t1O5cnVK8e=
Y25CRLwlRKTpVDbusob54dBmEtPlyMSi9REfkgoE34zkniyN1JVRwx3GZSh5AcdbrN5sNfscZEA=
TO_pzJfI1cg4TjNQbgk5biL7sSf28lDFvdrXp-l6ZZJ719iaFRqaInVUkKJErT2GKevERnmM6Hh=
yg1IhOYV-0hONDp5RfwPxDwwb2_tE5Y5LJ_VY_JnqLkhwyKM57psNYrsD2HsiCZHDWsIEIrKYCZ=
Mxpzu_33R6z-kA_ZLe7jrQ9eXzk13xETl_3w6BMdhW3gsmmfM9wq_O7mWmut5Mvn40r0tDTW9oR=
J1lh0Vkuy0yV-J-uoE8Y_8Uh4EJCKJYsf-mSFV9xcDFw9ozXbZeWzNsjIV/4og/qHX3SIYZQLKi=
y-AGcWTRMQ/h20/h001.xCbhcRq2jXc5uMQljkrFeKpXuzIAVdAQDeuYICY18eQ" target=3D"=
_blank" rel=3D"noopener noreferrer nofollow"><span>Amazon Storefront</span>=
</a></span></p></li></ul></div></td></tr><tr><td id=3D"get-discounts-on-you=
r-favorite-pept" class=3D"dd" align=3D"left" valign=3D"top" style=3D"color:=
#2A2A2A;font-weight:normal;padding:0px 15px;text-align:left;"><h3 style=3D"=
color:#2A2A2A;font-weight:normal;mso-line-height-alt:125.0%;"><span style=
=3D"font-size:1.5rem;">=F0=9F=91=89Get discounts on your favorite peptides =
and research chemicals:</span></h3></td></tr><tr><td style=3D"padding-botto=
m:12px;padding-left:37px;padding-right:27px;padding-top:12px;" class=3D"ee"=
><div style=3D"margin-left:0px;" class=3D"edm_outlooklist"><ul style=3D"fon=
t-weight:normal;list-style-type:disc;margin-bottom:12px !important;margin-t=
op:12px !important;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext">=
<p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-bre=
ak:break-word;"><span style=3D"color:#ff0000;font-family:Verdana,Geneva,san=
s-serif;font-size:1.5rem;font-weight:700;">PEPTIDES</span></p><ul style=3D"=
list-style-type:circle;margin:0px 0px;padding:0px 0px 0px 0px;"><li class=
=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;tex=
t-align:left;word-break:break-word;"><span style=3D"font-size:1.5rem;">BioL=
ongevity Labs (use code hunterw for 15% off):=C2=A0</span><span style=3D"fo=
nt-size:1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/ss=
/c/u001.XBXHqIRlWD2o7jctEk3ryW8PfZZTjR9oPVnqYq_MqtnRySH0u8MUZzep7T45dQc38E9=
qddqQFazrZwcfSWyeky4j4zKQnYsIwnWAgtqmwqlXLlZxbi4itsrIZ7fDRKlvMSs-2e8mQxq5EH=
CdsgjGchLXw40pUGvcq9Wh6Xuh2OeHg3G8lizRxXotQ5ynun_rwwm7yabyTYOIWwyhGTDCkn5-U=
8tY-74WaOmD6F5wT9hrKiUr733KnrtjpCoPulPK/4og/qHX3SIYZQLKiy-AGcWTRMQ/h21/h001=
.7bQza8GPyTGRms6hhIcUaDrLnvbQdnOHAVOhWYPHIbk" target=3D"_blank" rel=3D"noop=
ener noreferrer nofollow"><span>https://biolongevitylabs.com/</span></a></s=
pan><span style=3D"font-size:1.5rem;">=C2=A0</span></p></li></ul></li></ul>=
</div></td></tr><tr><td id=3D"10-off-my-favorite-protein-powder-a" class=3D=
"dd" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:norma=
l;padding:0px 15px;text-align:left;"><h3 style=3D"color:#2A2A2A;font-weight=
:normal;mso-line-height-alt:125.0%;"><span style=3D"font-size:1.5rem;">=F0=
=9F=91=8910% off the BEST workout supplements from Unmatched Supps (pre-wor=
kout, whey protein, creatine, EAAs, electrolytes - use code HUNTERW at chec=
kout):</span></h3></td></tr><tr><td style=3D"padding-bottom:12px;padding-le=
ft:37px;padding-right:27px;padding-top:12px;" class=3D"ee"><div style=3D"ma=
rgin-left:0px;" class=3D"edm_outlooklist"><ul style=3D"font-weight:normal;l=
ist-style-type:disc;margin-bottom:12px !important;margin-top:12px !importan=
t;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p style=3D"mso-l=
ine-height-alt:150.0%;padding:0px;text-align:left;word-break:break-word;"><=
span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https://link.mai=
l.beehiiv.com/ss/c/u001.fw6KhFr6V_IfF6b8t1O5chHLhboHu6O67eTKjF4PWfeso7_pnUT=
0XbhuaV9pa8ot2lM3iNw0vbqVksSx2Qk362rf_lGssmFxDX-qwmgkndnfDQMpxt8HZizoWnUMjU=
lcP_oCexOb17zBnPrD23Eys_4WedzDC8eNOsANbIj0HnnFHu4WRmjHz-F-j2f1aOR-xteLbw08q=
rJsRv_iFO0Rgapp35oU1EJsnSkP3v_CmmVYd0RAY38XGYP8azBSS9ulPS_2NN7fzMfTkfnK3KAn=
4tylSAUwWvE7i4cPGPxddVw/4og/qHX3SIYZQLKiy-AGcWTRMQ/h22/h001.XoviY2CWUJP0v1q=
v-haD5sGBBP73qPogV_6dbLuk8lM" target=3D"_blank" rel=3D"noopener noreferrer =
nofollow"><span>https://www.unmatchedsupps.com?sca_ref=3D8677061.S6mh8SOsog=
BzjOO</span></a></span></p></li></ul></div></td></tr><tr><td id=3D"submit-a=
-video-topic-for-my-next-yo" class=3D"dd" align=3D"left" valign=3D"top" sty=
le=3D"color:#2A2A2A;font-weight:normal;padding:0px 15px;text-align:left;"><=
h3 style=3D"color:#2A2A2A;font-weight:normal;mso-line-height-alt:125.0%;"><=
span style=3D"font-size:1.5rem;">=F0=9F=91=89Submit A Video Topic For My Ne=
xt YouTube Video:</span></h3></td></tr><tr><td style=3D"padding-bottom:12px=
;padding-left:37px;padding-right:27px;padding-top:12px;" class=3D"ee"><div =
style=3D"margin-left:0px;" class=3D"edm_outlooklist"><ul style=3D"font-weig=
ht:normal;list-style-type:disc;margin-bottom:12px !important;margin-top:12p=
x !important;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p sty=
le=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-break:bre=
ak-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https=
://link.mail.beehiiv.com/ss/c/u001.KRi0pFg1TnB-L5Xr4VTHbbemRY94TuUuyD0VE5om=
xSc2SjqVacq5qi_4g0zj8XDarQBkGZiWZ-Nfn6Sk_87h8y_3KNE0hxfAv4Sg3vbH5EQidQJPNk0=
Rt-PlaE_9CrIWHYfrEuNJA5MWAUO5NYxlSAEJycfKllLdqC5pJvXz2NhbHUXrXfbBSbEQqLL-Q9=
qc5JjevHI0O_Rl_uPdeTQPeZB_U0i0VlK1GCUOnBiLP6615bmc1yEm9JJ_VjZbxoicebiChq2yh=
4WO48eqWiG6tw/4og/qHX3SIYZQLKiy-AGcWTRMQ/h23/h001.VMT4Lr-UMlrHHyg8MbAq8JSwE=
jc5zmIfP-U03Uy1Ygk" target=3D"_blank" rel=3D"noopener noreferrer nofollow">=
<span>https://hunterwilliamsvideotopic.carrd.co/</span></a></span></p></li>=
</ul></div></td></tr><tr><td class=3D"w" align=3D"center" valign=3D"top" st=
yle=3D"padding:15px 15px 15px 15px;"><table role=3D"none" width=3D"100%" bo=
rder=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td ali=
gn=3D"center" valign=3D"top"><p style=3D"font-family:'Verdana',Geneva,sans-=
serif;color:#2D2D2D!important;"> Update your email preferences or unsubscri=
be <a class=3D"link" href=3D"https://link.mail.beehiiv.com/ss/c/u001.KRi0pF=
g1TnB-L5Xr4VTHbTUXhpH0c4aibrubwMtxLGHD31DhfnyGtZU8AZ6T-BAJdGuCacsXfIUqTdenm=
7u5wpKGaX_tXZgyK6_ie3JXweGarLcX-TkRxHhU7K3hUbohMUVMftGsM8mzVa_-sWNc010N79fm=
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