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From: Hunter Williams <huntershealthhacks@mail.beehiiv.com>
Reply-To: Hunter's Health Hacks <hunter@zeroats.com>
Subject: The Brain Peptide You Don't Know About
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Date: Tue, 27 Jan 2026 23:09:49 +0000
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Happy Tuesday! =0A=0AI just launched a brand new podcast episode on Spotify=
 that=E2=80=99s been a long time coming. =0A=0AI=E2=80=99ve wanted to cover=
 P21 for a while, but for a long stretch it was one of those peptides that =
was hard to source consistently in the research world. Fortunately, that ha=
s changed. =0A=0AP21 | The Brain Peptide Nobody Is Talking About: (https://=
open.spotify.com/episode/0tGTzCBkb5ApSBWSYuG2rC?si=3DYu3lrNo1S9u0cuNiWLqRNQ=
)=0A=0AP21 is a brain health peptide. =0A=0AIt sits in a lane different fro=
m the classic =E2=80=9Climitless=E2=80=9D nootropic vibe. =0A=0AIt=E2=80=99=
s closer to the world of neural repair, neurogenesis, and long-term brain r=
esilience. =0A=0AIf you=E2=80=99ve been around my content, you know I=E2=80=
=99m not the guy who leans on stimulatory brain compounds to perform. I lik=
e tools that make the system work better, so you need to force less over ti=
me.=0A=0AIn this email, I=E2=80=99m going to break down P21 the same way I =
did in the episode, covering the background, mechanisms, benefits, the actu=
al data, how I dose it, and who I think it fits best.=0A=0A=E2=80=94=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=
=94=0A=0A**Background and History**=0A=0AP21 is sometimes written as P021 i=
n the published literature. =0A=0AIt was developed as a small synthetic neu=
rotrophic peptide derived from ciliary neurotrophic factor (CNTF). =0A=0ACN=
TF has strong neurotrophic effects, but as a full protein, it has practical=
 limitations, such as delivery challenges and unwanted systemic effects. Re=
searchers wanted something smaller, more stable, and more usable.=0A=0AP21 =
is engineered as a short peptide with an adamantane modification that incre=
ases lipophilicity and helps it cross the blood-brain barrier more effectiv=
ely. =0A=0AIn other words, this was designed to actually reach the brain an=
d do meaningful work there, rather than a cool idea on paper that never tra=
nslates.=0A=0AThis peptide has been studied most heavily in the context of =
neurodegeneration and cognitive decline, especially Alzheimer=E2=80=99s dis=
ease models. =0A=0AIt also shows up in research on cognitive aging and deve=
lopmental models like Down syndrome. =0A=0AIt is not a mainstream compound =
yet, which is exactly why I wanted to bring it to the surface.=0A=0A=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=
=94=E2=80=94=0A=0A**Mechanisms**=0A=0AP21 is best understood as a neurotrop=
hic peptide mimetic. =0A=0AIt interfaces with CNTF-related signaling pathwa=
ys that influence neuronal survival, differentiation, and plasticity. =0A=
=0AMechanistically, it is associated with pathways like JAK/STAT3, MAPK, an=
d PI3K/Akt, which are heavily involved in how neurons adapt and survive und=
er stress.=0A=0AOne of the signature concepts around P21 is LIF inhibition,=
 meaning it interferes with leukemia inhibitory factor signaling. =0A=0ALIF=
 signaling can suppress aspects of neurogenesis, and P21 appears to reduce =
that brake, allowing neural stem cells to form new neurons more readily.=0A=
=0AThe other big headline is **BDNF upregulation**. =0A=0AP21 is associated=
 with increased expression of brain-derived neurotrophic factor, which then=
 triggers downstream TrkB signaling and PI3K/Akt activity. =0A=0AFrom there=
, a key downstream effect is inhibition of GSK3=CE=B2, which matters becaus=
e GSK3=CE=B2 activity is tied to tau phosphorylation, a hallmark of Alzheim=
er=E2=80=99s pathology.=0A=0AIn short, it supports regeneration and synapti=
c integrity through upstream trophic signaling.=0A=0A=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=
=0A**Benefits**=0A=0AThe benefits of P21 read like a checklist of what peop=
le want for long-term brain health. =0A=0AFirst, there is the cognitive ang=
le. In animal models, P21 improves learning and memory performance in both =
healthy and disease contexts. That includes improvements in object recognit=
ion memory and spatial learning tasks, which are common behavioral measures=
 used to evaluate memory.=0A=0ASecond, there is the neurogenesis and plasti=
city piece. P21 has been shown to increase markers of newborn neurons in th=
e dentate gyrus of the hippocampus, a brain region deeply tied to learning =
and memory. Alongside that, studies show improvements in synaptic markers t=
hat reflect stronger connectivity and synaptic maintenance.=0A=0AThird, the=
re is the neuroprotection angle. In Alzheimer=E2=80=99s models, P21 is link=
ed to reductions in tau pathology, and in some cases, modest improvements i=
n soluble amyloid measures. It also shows protective effects on dendritic a=
nd synaptic integrity, which is important because synaptic loss closely tra=
cks cognitive decline.=0A=0AIn plain language, P21 shows signs of helping t=
he brain stay clean, connected, and adaptable. For me personally, it feels =
like clarity without a =E2=80=9Cwired=E2=80=9D feeling. =0A=0AIt feels like=
 the brain runs more smoothly. I prefer this feel over the racy, stimulant =
feel from other higher-horsepower compounds.=0A=0A=E2=80=94=E2=80=94=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A=
**Clinical Data**=0A=0A_There are no published human clinical trials on P21=
_ in the way people expect when they ask for =E2=80=9Cclinical data.=E2=80=
=9D Most of what we have is animal data and mechanistic work.=0A=0AThe foun=
dational paper that put P21 on the map showed that peripheral administratio=
n enhanced learning and memory in normal adult mice and promoted neurogenes=
is and maturation of newly born neurons in the hippocampus.=C2=A0=0A=0AFrom=
 there, we see a consistent body of work in Alzheimer=E2=80=99s models. In =
the triple transgenic Alzheimer=E2=80=99s mouse model (3xTg-AD), chronic or=
al administration in the diet restored deficits in cognition, neurogenesis,=
 and synaptic plasticity, and strongly attenuated tau pathology.=C2=A0=0A=
=0AA major open-access paper later showed preventive effects on dendritic a=
nd synaptic deficits and cognitive impairment, again pointing to neurogenes=
is and synaptic protection as key outcomes.=C2=A0=0A=0AWe also have data in=
 cognitive aging and developmental models, including Down syndrome model mi=
ce, where early treatment improved developmental milestones and later-life =
cognitive outcomes (links to papers below).=0A=0A=E2=80=94=E2=80=94=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A=
**Dosage**=0A=0AAs always, this is not medical advice. This is purely discu=
ssion of research use and what I have observed personally and through conve=
rsations with others.=0A=0AIn my own use, I started conservatively. =0A=0AM=
y sweet spot for subcutaneous use has generally been **100 to 250 microgram=
s per day**, and I have seen many people do well in a **100 to 500 microgra=
m per day** range. =0A=0ASome people report more pronounced effects when th=
ey go higher, including into the milligram range, especially over multiple =
weeks. I do not think you need to start there.=0A=0AFor intranasal use, I h=
ave seen people use higher doses to achieve comparable effects, since intra=
nasal delivery can be variable. =0A=0AA common conceptual range discussed i=
s **1 to 4 mg per day** in divided doses, with smaller sprays multiple time=
s per day. If you go intranasal, I would still start low and earn your way =
up very slowly over time.=0A=0ACycling is flexible. I like 5 days on, 2 day=
s off, or even 3 days a week in periods of heavy work. =0A=0AIf someone has=
 active brain fog, high inflammation, or a history of concussions, daily us=
e for a period makes more sense.=0A=0ABioLongevity does not carry P21, but =
you can use my code HUNTER20 at [Soma Chems to try it out.](https://somache=
ms.com/product/p21/) =0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**Final Thoughts**=0A=0A=
P21 fits best for people who care about long-term brain health and want som=
ething that supports the system rather than blasting it. =0A=0AIf you have =
a demanding work schedule, a high cognitive load, and you want more clarity=
 without leaning on stimulants, P21 is interesting.=0A=0AIt also fits for p=
eople who have a history of concussions or head trauma. =0A=0ACerebrolysin =
remains the gold standardto me for neural repair. =0A=0AThe reality is that=
 sourcing is harder than it used to be, especially if you are not willing t=
o deal with crypto or international supply chain friction. =0A=0AIn my opin=
ion, P21 stands a viable alternative.=0A=0AP21 is a lighter, more accessibl=
e brain repair tool than Cerebrolysin. Unlike the complex biologic mixture =
of Cerebrolysin, P21 is a defined, engineered peptide. Both support repair =
and reduce neuroinflammation, but P21 does so more selectively.=0A=0AI also=
 think P21 fits for people who are already in decent brain health and want =
something they can use more frequently, without needing a heavy interventio=
n. =0A=0AIt is a maintenance tool that can become a performance tool when y=
our stress load rises.=0A=0AIn closing, thank you so much for being a reade=
r and supporter of my work. Without the support from readers like you, I wo=
uld not have the privilege to do what I do! =0A=0ABest,=0A=0AHunter William=
s=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=
=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=
=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=
=E2=80=94=E2=80=94=E2=80=94=0A=0A**Further Reading **=0A=0A* [https://febs.=
onlinelibrary.wiley.com/doi/10.1016/j.febslet.2010.06.025](https://febs.onl=
inelibrary.wiley.com/doi/10.1016/j.febslet.2010.06.025)=C2=A0=0A=0A* [https=
://pubmed.ncbi.nlm.nih.gov/20600002/](https://pubmed.ncbi.nlm.nih.gov/20600=
002/)=C2=A0=0A=0A* [https://www.sciencedirect.com/science/article/abs/pii/S=
0969996114001958](https://www.sciencedirect.com/science/article/abs/pii/S09=
69996114001958)=C2=A0=0A=0A* [https://pubmed.ncbi.nlm.nih.gov/25046994/](ht=
tps://pubmed.ncbi.nlm.nih.gov/25046994/)=C2=A0=0A=0A* [https://pmc.ncbi.nlm=
.nih.gov/articles/PMC5488423/](https://pmc.ncbi.nlm.nih.gov/articles/PMC548=
8423/)=C2=A0=0A=0A* [https://www.nature.com/articles/srep45561](https://www=
.nature.com/articles/srep45561)=C2=A0=0A=0A* [https://pubmed.ncbi.nlm.nih.g=
ov/24702821/](https://pubmed.ncbi.nlm.nih.gov/24702821/)=C2=A0=0A=0A* [http=
s://pmc.ncbi.nlm.nih.gov/articles/PMC8385525/](https://pmc.ncbi.nlm.nih.gov=
/articles/PMC8385525/)=C2=A0=0A=0A=0A=E2=80=94=E2=80=94=E2=80=94=0A=0AYou a=
re reading a plain text version of this post. For the best experience, copy=
 and paste this link in your browser to view the post online:=0Ahttps://hun=
tershealthhacks.beehiiv.com/p/the-brain-peptide-you-don-t-know-about
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ound-color:#FFFFFF;"><div role=3D"article" aria-roledescription=3D"email" a=
ria-label=3D"email_name" lang=3D"en" style=3D"font-size:1rem"><div style=3D=
"display:none;max-height:0px;overflow:hidden;"> New video on P21 is live! &=
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#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#16=
0;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&=
#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#820=
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60;&#8204;&#160;&#8204;&#160;&#8204;&#160;&#8204; </div><table role=3D"none=
" width=3D"100%" border=3D"0" cellspacing=3D"0" align=3D"center" cellpaddin=
g=3D"0" class=3D"gg"><tr><td align=3D"center" valign=3D"top"><table role=3D=
"none" width=3D"670" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" class=
=3D"aa" style=3D"width:670px;table-layout:fixed;"><tr><td class=3D"bodyWrap=
per" align=3D"center" valign=3D"top" style=3D"padding:10px 5px 10px 5px;"><=
table role=3D"none" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpaddi=
ng=3D"0" align=3D"center"><tr><td align=3D"center" valign=3D"top" style=3D"=
border-width:0px 0px 0px 0px;border-style: solid; border-color: #FFFFFF;bor=
der-radius:10px 10px 0px 0px;background-color:#FFFFFF;" class=3D"c"><table =
role=3D"none" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"=
0" align=3D"center"><tr id=3D"header"><td style=3D"padding:15px 15px 0px 15=
px;"><div style=3D"padding-top:0px;padding-right:0px;padding-bottom:20px;pa=
dding-left:0px;"><table role=3D"none" width=3D"100%" border=3D"0" cellspaci=
ng=3D"0" cellpadding=3D"0" align=3D"center"><tr><td class=3D"f" align=3D"ri=
ght" valign=3D"top"><p> January 27, 2026 &nbsp; | &nbsp; <a href=3D"https:/=
/link.mail.beehiiv.com/v1/c/GZhT8rImA7OWdzolmAIKSCWUANA%2FuWXnKNkqODGBownxf=
GJW43yLGtAfMHy8%0ATEgSYOLWxGGjM8lJ6xAjBrRVSTgKhIAoUdJKRpKQKJAzOT%2FvbSBEYVu=
5MnC%2F%0AnY14loHks0BqLM31pPPaxI5U2xOlpH%2FwGH1kWSnPRM%2FqvpfbskQ%3D%0A/039=
fcebc700351e4"><span class=3D"translation_missing" title=3D"translation mis=
sing: en.templates.posts.email.header.listen_online">Listen Online</span></=
a> &nbsp; | &nbsp; <a href=3D"https://link.mail.beehiiv.com/v1/c/AbtFBmRVGO=
1Si5%2FIAr18O8Rpm2YBpccd1JDKRrXeJ35BPs91tgAiKxnTotWu%0AD%2BPCO8udtxEX1g5ji9=
S%2F%2FWpGRdbvwU%2F1YAhTKfmHNRHufnIhS323C%2FS95jVE%0A9RPTmtUMkZ9E6wbuQhDa8E=
q00nMdHszvVAxf06SyCbTSTgo8KnU%3D%0A/b4a52ce68d43e875"><span class=3D"transl=
ation_missing" title=3D"translation missing: en.templates.posts.email.heade=
r.read_online">Read Online</span></a></p></td></tr><tr><td class=3D"dd" ali=
gn=3D"center" valign=3D"top" style=3D"padding:15px 0;"><table role=3D"none"=
 width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"c=
enter"><tr><td align=3D"center" valign=3D"top"><h1 style=3D"text-align:left=
;font-family:'Trebuchet MS','Lucida Grande',Tahoma,sans-serif;font-weight:B=
old;font-size:32px;color:#2A2A2A;padding:2px 0;line-height:38px;"> The Brai=
n Peptide You Don&#39;t Know About </h1><p style=3D"text-align:left;font-fa=
mily:'Helvetica',Arial,sans-serif;font-weight:normal;font-size:20px;color:#=
3E3E3E;padding:5px 0;line-height:24px;"> New video on P21 is live! </p></td=
></tr></table></td></tr><tr><td align=3D"center" valign=3D"top" class=3D"dd=
"><table role=3D"none" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpa=
dding=3D"0" align=3D"center"><tr><td align=3D"left" valign=3D"middle" class=
=3D"mob-stack"><table role=3D"none" border=3D"0" cellspacing=3D"0" cellpadd=
ing=3D"0" align=3D"right" class=3D"social-mobile"><tr><td align=3D"left" va=
lign=3D"middle"><table role=3D"none" border=3D"0" cellspacing=3D"0" cellpad=
ding=3D"0" align=3D"left" style=3D"width:100%"><tr><td align=3D"center" val=
ign=3D"middle"><a href=3D"https://link.mail.beehiiv.com/v1/c/QxQkHVvSNsO%2F=
5TQJnurvl5KvDv58fwoGrGY49DvLqaAL8iTfImgQFmW98azP%0A6RnZ5RvoSwK1VtEsR9HFabcO=
pWQOdPBK6h9TP89J68GLg0XdjPA0qNAyCGQh%0AXaG1BKzcYNfBXJ%2BW2vwChc8Mi1L0CzGKvm=
FG12efP24BXWrczBs%3D%0A/e4d9dc4ed31f0fe7" style=3D"text-decoration:none; di=
splay:block;"><table role=3D"none" border=3D"0" cellspacing=3D"0" cellpaddi=
ng=3D"0" align=3D"center"><tr><td align=3D"center" valign=3D"middle" style=
=3D"border: 1px solid #E5E7EB; border-radius: 100%; width: 18px; height: 18=
px; padding: 8px;"><img style=3D"display:block; width:100%; height:100%; ma=
x-width:18px; max-height:18px; object-fit: contain;" alt=3D"share on facebo=
ok" width=3D"18" border=3D"0" src=3D"https://media.beehiiv.com/cdn-cgi/imag=
e/fit=3Dscale-down,format=3Dauto,onerror=3Dredirect,quality=3D80/static_ass=
ets/header/facebook.png"/></td></tr></table></a></td><td width=3D"8" style=
=3D"width:8px;">&nbsp;</td><td align=3D"center" valign=3D"middle"><a href=
=3D"https://link.mail.beehiiv.com/v1/c/FGy58LvSigrSUMD97i4EQ4hJ0Eg6esM6bxOt=
ShXwQdCI9jMFfKmf4felOz9Y%0AyERoBd2Q5FnGVuz71DJ1hRPMPuA3Yz%2FUG57ZbL3lRgfbwQ=
3MkP7U9pTZGemJ%0AMylEpWkCMbXQgytMLXG0uxiZq2HjOqiVWurA7eRc7tk3NiniqfI%3D%0A/=
e46e04d9630c37fb" style=3D"text-decoration:none; display:block;"><table rol=
e=3D"none" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center=
"><tr><td align=3D"center" valign=3D"middle" style=3D"border: 1px solid #E5=
E7EB; border-radius: 100%; width: 18px; height: 18px; padding: 8px;"><img s=
tyle=3D"display:block; width:100%; height:100%; max-width:18px; max-height:=
18px; object-fit: contain;" alt=3D"share on twitter" width=3D"18" height=3D=
"18" border=3D"0" src=3D"https://media.beehiiv.com/cdn-cgi/image/fit=3Dscal=
e-down,format=3Dauto,onerror=3Dredirect,quality=3D80/static_assets/header/x=
.png"/></td></tr></table></a></td><td width=3D"8" style=3D"width:8px;">&nbs=
p;</td><td align=3D"center" valign=3D"middle"><a href=3D"https://link.mail.=
beehiiv.com/v1/c/bSckO5hXejCCdC8n2eABdjYD%2FVPXdu41Seawg1WoGO%2FnFOwEfiOA46=
9OzQMQ%0AFKqr3RG8urXF9F0DnO6vIwWNfrKgpoLWNvmnAH63T0fPGgHXkw0XalHLXJgl%0A0IO=
gl668D9GBKXaAt1TrDOwPnwSpr0epp%2Fdp7KHhdO5KIMZa7QI%3D%0A/05cc0aa7512a0846" =
style=3D"text-decoration:none; display:block;"><table role=3D"none" border=
=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td align=
=3D"center" valign=3D"middle" style=3D"border: 1px solid #E5E7EB; border-ra=
dius: 100%; width: 18px; height: 18px; padding: 8px;"><img style=3D"display=
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t: contain;" alt=3D"share on threads" width=3D"18" height=3D"18" border=3D"=
0" src=3D"https://media.beehiiv.com/cdn-cgi/image/fit=3Dscale-down,format=
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</td></tr></table></a></td><td width=3D"8" style=3D"width:8px;">&nbsp;</td>=
<td align=3D"center" valign=3D"middle"><a href=3D"https://link.mail.beehiiv=
.com/v1/c/7ojt3Dr3YafG9M9BFK%2Bya1Rjte8OsMBgc6XSOUahGsbmzj%2BsYaLv1Cx7s%2BM=
L%0AUi%2F6zFM9PKFdXWcdmuTagI28oND56aFUCleX1pIb2%2BtMcHODBGppprx7fiWK%0Asj%2=
Bdrb4SYQkTjXU%2FYJcYsnBGdGtEq3klxa93eoJY2gY0uFbAoJs%3D%0A/f9eb1f97cef587ed"=
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=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td align=
=3D"center" valign=3D"middle" style=3D"border: 1px solid #E5E7EB; border-ra=
dius: 100%; width: 18px; height: 18px; padding: 8px;"><img style=3D"display=
:block; width:100%; height:100%; max-width:18px; max-height:18px; object-fi=
t: contain;" alt=3D"share on linkedin" width=3D"18" height=3D"18" border=3D=
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e></td></tr><tr><td style=3D"line-height:0;"><div data-open-tracking=3D"tru=
e"><img src=3D"https://link.mail.beehiiv.com/v1/o/JYaan2tbNQ8SZCx2kE3s960WC=
tewnSIkzc6Leh23NpwoG0Cj6gNBp9ubj1yA%0ASl0HjmADMyGJG%2BDpd%2BFdjonznXiuwHiWQ=
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2Fi3zTbNjTq0nIS%2FKkQcg%2FP%0AKhef0v9QoTgAbBXTTQLrdBTrHp0LS59kMehhNgxO4vKqt=
xTHlX06oV7gPgcs%0AT4eg1NTcnwH6u0ll1y0GFocBp%2ByVuUJQFYKXh49D1%2Bg2BYi8Mhen9=
5BhWu8Q%0Aw8%2FZCeznOyX%2F%2BkczObJnQt4aXl0tIFIi49T1i1z7oSYhMRenTmLqf5B0mMT=
o%0Azqs%3D%0A/28679cc6af50d2a1.gif" alt=3D"" width=3D"1" height=3D"1" style=
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/tr><tr id=3D"content-blocks"><td class=3D"email-card-body" align=3D"center=
" valign=3D"top" style=3D"padding-bottom:px;"><table role=3D"none" width=3D=
"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><t=
r><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left=
;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span sty=
le=3D"font-size:1.5rem;">Happy Tuesday! </span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">I just launched a brand new podcast episode on Spotify that=
=E2=80=99s been a long time coming. </span></p></td></tr><tr><td class=3D"d=
d" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:brea=
k-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:=
1.5rem;">I=E2=80=99ve wanted to cover P21 for a while, but for a long stret=
ch it was one of those peptides that was hard to source consistently in the=
 research world. Fortunately, that has changed. </span></p></td></tr><tr cl=
ass=3D"embed-gen-img-r"><td align=3D"center" valign=3D"top" style=3D"paddin=
g:12px 27px 12px 27px;" class=3D"dd"><table role=3D"none" width=3D"100%" bo=
rder=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td ali=
gn=3D"center" valign=3D"top" class=3D"o" style=3D"padding:12px 12px 12px 12=
px;;background-color:#FFFFFF;border-color:#F1F1F1;border-radius:5px 5px 5px=
 5px;border-width:1px 1px 1px 1px;"><!--[if !mso]><!--><div style=3D"displa=
y:none; float:left; overflow:hidden; width:0; max-height:0; line-height:0;"=
 class=3D"mob-show"><table role=3D"none" border=3D"0" cellspacing=3D"0" cel=
lpadding=3D"0" align=3D"right" width=3D"100%"><tr><td align=3D"center" vali=
gn=3D"top"><a href=3D"https://link.mail.beehiiv.com/v1/c/EIcYK6OQ2iHM4fZBet=
xFGtgz36Cw8gRbdKYgq4RFQl%2FpfBObj9blZ2Sn6r%2B4%0Ac%2F%2FSoXxfHDkkuTOvC4g6Gy=
VGiLZoLLY%2FQXgPEZ78tzms8%2F19EE5BePXUx%2F5j%0AZGX7knAZgdyhfTv5WgWf8d7cms4Y=
57n%2FX6KyMi3ER0hLrYJfOK8%3D%0A/83df18e2b53364eb" target=3D"_blank"><img sr=
c=3D"https://image-cdn-ak.spotifycdn.com/image/ab6772ab0000169296c8446465c2=
1e7e82c32cda" width=3D"100%" style=3D"height:auto;display:block;"/></a></td=
></tr><tr><td height=3D"16" style=3D"font-size:16px;line-height:16px;">&nbs=
p;</td></tr></table></div><!--<![endif]--><table role=3D"none" border=3D"0"=
 cellspacing=3D"0" cellpadding=3D"0" align=3D"right" width=3D"100%"><tr><td=
 width=3D"57%" align=3D"center" valign=3D"middle" class=3D"mob-stack"><tabl=
e role=3D"none" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=
=3D"0" align=3D"center"><tr><td align=3D"left" valign=3D"middle" class=3D"l=
"><p><a href=3D"https://link.mail.beehiiv.com/v1/c/jNLpp8YknoczVFGi9MuHXmsy=
gZa1LdIphJJyyt8rqJhpgmBQogCntMdsBS7t%0ACnRm8KsGsNj%2BC5G6kdLrrS11qNEX%2BLgw=
XBAmkTXZOolGhrz9T2c0TNBSfCHY%0AgvRTMVGdj%2F9If37LDiAW%2BX13QSAigJDWmmVxxu%2=
FHfqABM0GNp2c%3D%0A/2a7ee4caa6a93213" style=3D"text-decoration:none;font-st=
yle:normal;color:#2D2D2D !important;font-size:14px;line-height:20px;" targe=
t=3D"_blank"> P21 | The Brain Peptide Nobody Is Talking About <tr><td align=
=3D"left" valign=3D"top" class=3D"m"><p style=3D"font-size:13px;line-height=
:19px;color:#2D2D2D;"> The Hunter Williams Podcast =C2=B7 Episode </p></td>=
</tr><tr><td align=3D"left" valign=3D"bottom" class=3D"n" style=3D"vertical=
-align:bottom;padding-top:12px;"><p style=3D"word-break:break-word;">open.s=
potify.com/episode/0tGTzCBkb5ApSBWSYuG2rC?si=3DYu3lrNo1S9u0cuNiWLqRNQ</p></=
td></tr></a></p></td></tr></table></td><td width=3D"3%" style=3D"font-size:=
16px;line-height:16px;" class=3D"mob-hide">&nbsp;</td><td width=3D"40%" ali=
gn=3D"left" valign=3D"top" class=3D"mob-hide"><a href=3D"https://link.mail.=
beehiiv.com/v1/c/Wtx%2Bx3pAxJXeLP4UgN7eURwdqL7bHcWjg7ujkGbFsEd3D5ClX98gF5Tf=
PywE%0AlN3bPuFJYRugPp1ZHpYLCDs%2Be4R%2FjFhrri4mYZpDS15RbHfqaIOU4VHw655g%0A6=
r3ZLDMRYvIP5w8sEiLHOHDCr%2FRiqkgyar%2BIDqf8GXJ9sc6GGsE%3D%0A/c28f0524d445fd=
7f" target=3D"_blank"><img src=3D"https://image-cdn-ak.spotifycdn.com/image=
/ab6772ab0000169296c8446465c21e7e82c32cda" width=3D"232" style=3D"height:au=
to;display:block;"/></a></td></tr></table></td></tr></table></td></tr><tr><=
td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wo=
rd-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">P21 is a brain health peptide. </span></p></td></tr>=
<tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:le=
ft;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span s=
tyle=3D"font-size:1.5rem;">It sits in a lane different from the classic =E2=
=80=9Climitless=E2=80=9D nootropic vibe. </span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">It=E2=80=99s closer to the world of neural repair, neurogenes=
is, and long-term brain resilience. </span></p></td></tr><tr><td class=3D"d=
d" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:brea=
k-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:=
1.5rem;">If you=E2=80=99ve been around my content, you know I=E2=80=99m not=
 the guy who leans on stimulatory brain compounds to perform. I like tools =
that make the system work better, so you need to force less over time.</spa=
n></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15=
px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:=
150.0%;"><span style=3D"font-size:1.5rem;">In this email, I=E2=80=99m going=
 to break down P21 the same way I did in the episode, covering the backgrou=
nd, mechanisms, benefits, the actual data, how I dose it, and who I think i=
t fits best.</span></p></td></tr><tr><td align=3D"center" valign=3D"top" st=
yle=3D"font-size:0px;line-height:0px;padding:30px 0px 30px;" class=3D"dd"><=
table class=3D"j" role=3D"none" width=3D"50%" border=3D"0" cellspacing=3D"0=
" cellpadding=3D"0" align=3D"center"><tr><td> &nbsp; </td></tr></table></td=
></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-al=
ign:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><=
span style=3D"font-size:1.5rem;"><b>Background and History</b></span></p></=
td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-=
align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"=
><span style=3D"font-size:1.5rem;">P21 is sometimes written as P021 in the =
published literature. </span></p></td></tr><tr><td class=3D"dd" align=3D"le=
ft" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p st=
yle=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">It wa=
s developed as a small synthetic neurotrophic peptide derived from ciliary =
neurotrophic factor (CNTF). </span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
>CNTF has strong neurotrophic effects, but as a full protein, it has practi=
cal limitations, such as delivery challenges and unwanted systemic effects.=
 Researchers wanted something smaller, more stable, and more usable.</span>=
</p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px=
;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:15=
0.0%;"><span style=3D"font-size:1.5rem;">P21 is engineered as a short pepti=
de with an adamantane modification that increases lipophilicity and helps i=
t cross the blood-brain barrier more effectively. </span></p></td></tr><tr>=
<td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;w=
ord-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">In other words, this was designed to actually reach =
the brain and do meaningful work there, rather than a cool idea on paper th=
at never translates.</span></p></td></tr><tr><td class=3D"dd" align=3D"left=
" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p styl=
e=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">This pe=
ptide has been studied most heavily in the context of neurodegeneration and=
 cognitive decline, especially Alzheimer=E2=80=99s disease models. </span><=
/p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;=
text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150=
.0%;"><span style=3D"font-size:1.5rem;">It also shows up in research on cog=
nitive aging and developmental models like Down syndrome. </span></p></td><=
/tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-alig=
n:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><sp=
an style=3D"font-size:1.5rem;">It is not a mainstream compound yet, which i=
s exactly why I wanted to bring it to the surface.</span></p></td></tr><tr>=
<td align=3D"center" valign=3D"top" style=3D"font-size:0px;line-height:0px;=
padding:30px 0px 30px;" class=3D"dd"><table class=3D"j" role=3D"none" width=
=3D"50%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center">=
<tr><td> &nbsp; </td></tr></table></td></tr><tr><td class=3D"dd" align=3D"l=
eft" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p s=
tyle=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"><b>M=
echanisms</b></span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=
=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"ms=
o-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">P21 is best un=
derstood as a neurotrophic peptide mimetic. </span></p></td></tr><tr><td cl=
ass=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-br=
eak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"fo=
nt-size:1.5rem;">It interfaces with CNTF-related signaling pathways that in=
fluence neuronal survival, differentiation, and plasticity. </span></p></td=
></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-al=
ign:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><=
span style=3D"font-size:1.5rem;">Mechanistically, it is associated with pat=
hways like JAK/STAT3, MAPK, and PI3K/Akt, which are heavily involved in how=
 neurons adapt and survive under stress.</span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">One of the signature concepts around P21 is LIF inhibition, m=
eaning it interferes with leukemia inhibitory factor signaling. </span></p>=
</td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;tex=
t-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%=
;"><span style=3D"font-size:1.5rem;">LIF signaling can suppress aspects of =
neurogenesis, and P21 appears to reduce that brake, allowing neural stem ce=
lls to form new neurons more readily.</span></p></td></tr><tr><td class=3D"=
dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:bre=
ak-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size=
:1.5rem;">The other big headline is </span><span style=3D"font-size:1.5rem;=
"><b>BDNF upregulation</b></span><span style=3D"font-size:1.5rem;">. </span=
></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15p=
x;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:1=
50.0%;"><span style=3D"font-size:1.5rem;">P21 is associated with increased =
expression of brain-derived neurotrophic factor, which then triggers downst=
ream TrkB signaling and PI3K/Akt activity. </span></p></td></tr><tr><td cla=
ss=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-bre=
ak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"fon=
t-size:1.5rem;">From there, a key downstream effect is inhibition of GSK3=
=CE=B2, which matters because GSK3=CE=B2 activity is tied to tau phosphoryl=
ation, a hallmark of Alzheimer=E2=80=99s pathology.</span></p></td></tr><tr=
><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;=
word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span styl=
e=3D"font-size:1.5rem;">In short, it supports regeneration and synaptic int=
egrity through upstream trophic signaling.</span></p></td></tr><tr><td alig=
n=3D"center" valign=3D"top" style=3D"font-size:0px;line-height:0px;padding:=
30px 0px 30px;" class=3D"dd"><table class=3D"j" role=3D"none" width=3D"50%"=
 border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td>=
 &nbsp; </td></tr></table></td></tr><tr><td class=3D"dd" align=3D"left" sty=
le=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"=
mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"><b>Benefits<=
/b></span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"paddin=
g:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-line-hei=
ght-alt:150.0%;"><span style=3D"font-size:1.5rem;">The benefits of P21 read=
 like a checklist of what people want for long-term brain health. </span></=
p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;t=
ext-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.=
0%;"><span style=3D"font-size:1.5rem;">First, there is the cognitive angle.=
 In animal models, P21 improves learning and memory performance in both hea=
lthy and disease contexts. That includes improvements in object recognition=
 memory and spatial learning tasks, which are common behavioral measures us=
ed to evaluate memory.</span></p></td></tr><tr><td class=3D"dd" align=3D"le=
ft" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p st=
yle=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Secon=
d, there is the neurogenesis and plasticity piece. P21 has been shown to in=
crease markers of newborn neurons in the dentate gyrus of the hippocampus, =
a brain region deeply tied to learning and memory. Alongside that, studies =
show improvements in synaptic markers that reflect stronger connectivity an=
d synaptic maintenance.</span></p></td></tr><tr><td class=3D"dd" align=3D"l=
eft" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p s=
tyle=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Thir=
d, there is the neuroprotection angle. In Alzheimer=E2=80=99s models, P21 i=
s linked to reductions in tau pathology, and in some cases, modest improvem=
ents in soluble amyloid measures. It also shows protective effects on dendr=
itic and synaptic integrity, which is important because synaptic loss close=
ly tracks cognitive decline.</span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
>In plain language, P21 shows signs of helping the brain stay clean, connec=
ted, and adaptable. For me personally, it feels like clarity without a =E2=
=80=9Cwired=E2=80=9D feeling. </span></p></td></tr><tr><td class=3D"dd" ali=
gn=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word=
;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem=
;">It feels like the brain runs more smoothly. I prefer this feel over the =
racy, stimulant feel from other higher-horsepower compounds.</span></p></td=
></tr><tr><td align=3D"center" valign=3D"top" style=3D"font-size:0px;line-h=
eight:0px;padding:30px 0px 30px;" class=3D"dd"><table class=3D"j" role=3D"n=
one" width=3D"50%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=
=3D"center"><tr><td> &nbsp; </td></tr></table></td></tr><tr><td class=3D"dd=
" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break=
-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1=
.5rem;"><b>Clinical Data</b></span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
><i>There are no published human clinical trials on P21</i></span><span sty=
le=3D"font-size:1.5rem;"> in the way people expect when they ask for =E2=80=
=9Cclinical data.=E2=80=9D Most of what we have is animal data and mechanis=
tic work.</span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"=
padding:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-li=
ne-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">The foundational p=
aper that put P21 on the map showed that peripheral administration enhanced=
 learning and memory in normal adult mice and promoted neurogenesis and mat=
uration of newly born neurons in the hippocampus.=C2=A0</span></p></td></tr=
><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:l=
eft;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span =
style=3D"font-size:1.5rem;">From there, we see a consistent body of work in=
 Alzheimer=E2=80=99s models. In the triple transgenic Alzheimer=E2=80=99s m=
ouse model (3xTg-AD), chronic oral administration in the diet restored defi=
cits in cognition, neurogenesis, and synaptic plasticity, and strongly atte=
nuated tau pathology.=C2=A0</span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
>A major open-access paper later showed preventive effects on dendritic and=
 synaptic deficits and cognitive impairment, again pointing to neurogenesis=
 and synaptic protection as key outcomes.=C2=A0</span></p></td></tr><tr><td=
 class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word=
-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D=
"font-size:1.5rem;">We also have data in cognitive aging and developmental =
models, including Down syndrome model mice, where early treatment improved =
developmental milestones and later-life cognitive outcomes (links to papers=
 below).</span></p></td></tr><tr><td align=3D"center" valign=3D"top" style=
=3D"font-size:0px;line-height:0px;padding:30px 0px 30px;" class=3D"dd"><tab=
le class=3D"j" role=3D"none" width=3D"50%" border=3D"0" cellspacing=3D"0" c=
ellpadding=3D"0" align=3D"center"><tr><td> &nbsp; </td></tr></table></td></=
tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align=
:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><spa=
n style=3D"font-size:1.5rem;"><b>Dosage</b></span></p></td></tr><tr><td cla=
ss=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-bre=
ak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"fon=
t-size:1.5rem;">As always, this is not medical advice. This is purely discu=
ssion of research use and what I have observed personally and through conve=
rsations with others.</span></p></td></tr><tr><td class=3D"dd" align=3D"lef=
t" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p sty=
le=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">In my =
own use, I started conservatively. </span></p></td></tr><tr><td class=3D"dd=
" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break=
-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1=
.5rem;">My sweet spot for subcutaneous use has generally been </span><span =
style=3D"font-size:1.5rem;"><b>100 to 250 micrograms per day</b></span><spa=
n style=3D"font-size:1.5rem;">, and I have seen many people do well in a </=
span><span style=3D"font-size:1.5rem;"><b>100 to 500 microgram per day</b><=
/span><span style=3D"font-size:1.5rem;"> range. </span></p></td></tr><tr><t=
d class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wor=
d-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">Some people report more pronounced effects when they=
 go higher, including into the milligram range, especially over multiple we=
eks. I do not think you need to start there.</span></p></td></tr><tr><td cl=
ass=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-br=
eak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"fo=
nt-size:1.5rem;">For intranasal use, I have seen people use higher doses to=
 achieve comparable effects, since intranasal delivery can be variable. </s=
pan></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px =
15px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-al=
t:150.0%;"><span style=3D"font-size:1.5rem;">A common conceptual range disc=
ussed is </span><span style=3D"font-size:1.5rem;"><b>1 to 4 mg per day</b><=
/span><span style=3D"font-size:1.5rem;"> in divided doses, with smaller spr=
ays multiple times per day. If you go intranasal, I would still start low a=
nd earn your way up very slowly over time.</span></p></td></tr><tr><td clas=
s=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-brea=
k:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font=
-size:1.5rem;">Cycling is flexible. I like 5 days on, 2 days off, or even 3=
 days a week in periods of heavy work. </span></p></td></tr><tr><td class=
=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break=
:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-=
size:1.5rem;">If someone has active brain fog, high inflammation, or a hist=
ory of concussions, daily use for a period makes more sense.</span></p></td=
></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-al=
ign:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><=
span style=3D"font-size:1.5rem;">BioLongevity does not carry P21, but you c=
an use my code HUNTER20 at </span><span style=3D"font-size:1.5rem;"><a clas=
s=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/P4sal0P8Ecqzzxwjz9ShS=
whV4hY42cNBmU3EDIZGS01RhkMjMdT0BKJVhimW%0A2UDEwV2aot0F7Ydg2%2B4UwyAr8rYIKaD=
Z4bWCCOrOhO2fcnGmUzaxhm1gFzEY%0ARDGYFmTti5sc1GVZxpvzn%2F7gto857h5a1Z6xK7Wty=
tM1jzU9HcY%3D%0A/d86e4f2fd45d0364" target=3D"_blank" rel=3D"noopener norefe=
rrer nofollow"><span>Soma Chems to try it out.</span></a></span><span style=
=3D"font-size:1.5rem;">=C2=A0</span></p></td></tr><tr><td align=3D"center" =
valign=3D"top" style=3D"font-size:0px;line-height:0px;padding:30px 0px 30px=
;" class=3D"dd"><table class=3D"j" role=3D"none" width=3D"50%" border=3D"0"=
 cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td> &nbsp; </td>=
</tr></table></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding=
:0px 15px;text-align:left;word-break:break-word;"><p style=3D"mso-line-heig=
ht-alt:150.0%;"><span style=3D"font-size:1.5rem;"><b>Final Thoughts</b></sp=
an></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 1=
5px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt=
:150.0%;"><span style=3D"font-size:1.5rem;">P21 fits best for people who ca=
re about long-term brain health and want something that supports the system=
 rather than blasting it. </span></p></td></tr><tr><td class=3D"dd" align=
=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"=
><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;"=
>If you have a demanding work schedule, a high cognitive load, and you want=
 more clarity without leaning on stimulants, P21 is interesting.</span></p>=
</td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;tex=
t-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%=
;"><span style=3D"font-size:1.5rem;">It also fits for people who have a his=
tory of concussions or head trauma. </span></p></td></tr><tr><td class=3D"d=
d" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:brea=
k-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:=
1.5rem;">Cerebrolysin remains the gold standardto me for neural repair. </s=
pan></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px =
15px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-al=
t:150.0%;"><span style=3D"font-size:1.5rem;">The reality is that sourcing i=
s harder than it used to be, especially if you are not willing to deal with=
 crypto or international supply chain friction. </span></p></td></tr><tr><t=
d class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wor=
d-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=
=3D"font-size:1.5rem;">In my opinion, P21 stands a viable alternative.</spa=
n></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15=
px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:=
150.0%;"><span style=3D"font-size:1.5rem;">P21 is a lighter, more accessibl=
e brain repair tool than Cerebrolysin. Unlike the complex biologic mixture =
of Cerebrolysin, P21 is a defined, engineered peptide. Both support repair =
and reduce neuroinflammation, but P21 does so more selectively.</span></p><=
/td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text=
-align:left;word-break:break-word;"><p style=3D"mso-line-height-alt:150.0%;=
"><span style=3D"font-size:1.5rem;">I also think P21 fits for people who ar=
e already in decent brain health and want something they can use more frequ=
ently, without needing a heavy intervention. </span></p></td></tr><tr><td c=
lass=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-b=
reak:break-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"f=
ont-size:1.5rem;">It is a maintenance tool that can become a performance to=
ol when your stress load rises.</span></p></td></tr><tr><td class=3D"dd" al=
ign=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break-wor=
d;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5re=
m;">In closing, thank you so much for being a reader and supporter of my wo=
rk. Without the support from readers like you, I would not have the privile=
ge to do what I do! </span></p></td></tr><tr><td class=3D"dd" align=3D"left=
" style=3D"padding:0px 15px;text-align:left;word-break:break-word;"><p styl=
e=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1.5rem;">Best,</=
span></p></td></tr><tr><td class=3D"dd" align=3D"left" style=3D"padding:0px=
 15px;text-align:left;word-break:break-word;"><p style=3D"mso-line-height-a=
lt:150.0%;"><span style=3D"font-size:1.5rem;">Hunter Williams</span></p></t=
d></tr><tr><td align=3D"center" valign=3D"top" style=3D"font-size:0px;line-=
height:0px;padding:30px 0px 30px;" class=3D"dd"><table class=3D"j" role=3D"=
none" width=3D"50%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=
=3D"center"><tr><td> &nbsp; </td></tr></table></td></tr><tr><td class=3D"dd=
" align=3D"left" style=3D"padding:0px 15px;text-align:left;word-break:break=
-word;"><p style=3D"mso-line-height-alt:150.0%;"><span style=3D"font-size:1=
.5rem;"><b>Further Reading </b></span></p></td></tr><tr><td style=3D"paddin=
g-bottom:12px;padding-left:37px;padding-right:27px;padding-top:12px;" class=
=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_outlooklist"><ul style=
=3D"font-weight:normal;list-style-type:disc;margin-bottom:12px !important;m=
argin-top:12px !important;padding:0px 0px 0px 0px;"><li class=3D"listItem u=
ltext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;w=
ord-break:break-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" =
href=3D"https://link.mail.beehiiv.com/v1/c/%2FWC8sxKwhJSWICFK0PvoRCv1uq9BjI=
XbOw%2BYlba9S4Ubppu5lufDMonqXr%2FC%0AORn0pssQriwkAgM%2F7xerTK8PcW0pEwsLMSSQ=
uDfB5fqMVoq8jd1dWyfCZVGX%0ALr4waGykoUiUQwEhOQ%2Bv9wfArcYLa3LK57dRZwv0CgpXWq=
r7Q3c%3D%0A/5ecff0efc57db5a7" target=3D"_blank" rel=3D"noopener noreferrer =
nofollow"><span>https://febs.onlinelibrary.wiley.com/doi/10.1016/j.febslet.=
2010.06.025</span></a></span><span style=3D"font-size:1.5rem;">=C2=A0</span=
></p></li><li class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150=
.0%;padding:0px;text-align:left;word-break:break-word;"><span style=3D"font=
-size:1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c=
/W9uqIXeUnfr1gILLHTEUZMOQsNC4S9KMcGzt151ytPA9RJvF9EHIxjk%2Bk5N8%0ACaST3s%2B=
WM27pWSetcnnNiYp8UOCM3gY0hIJKvPYwJuIYNVNKgvGXH7%2B7FUMC%0AtFW4mDB8BgP8r9Uan=
C8ONIC8w9LWsKqJVBVCM3PvwtGDALOflKA%3D%0A/e9fb24aa88772891" target=3D"_blank=
" rel=3D"noopener noreferrer nofollow"><span>https://pubmed.ncbi.nlm.nih.go=
v/20600002/</span></a></span><span style=3D"font-size:1.5rem;">=C2=A0</span=
></p></li><li class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150=
.0%;padding:0px;text-align:left;word-break:break-word;"><span style=3D"font=
-size:1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c=
/xjIkwOook8jxT%2Bp5vc2J1zi%2Btn6ydpFzCi%2F9F2J5J4TLocNtZ30ohT7U17Gq%0AJtaIk=
fAi%2F%2B80L4TySNIGodSZ8morNqXRwZWDHuHCSUu5TcROjYW7BzjM95fg%0AiiK61Si6IVLa9=
AGzyw5Ix9zfyaIpxs6kWvJlaYUElPVpQWYNxiw%3D%0A/431e5b4ac216e336" target=3D"_b=
lank" rel=3D"noopener noreferrer nofollow"><span>https://www.sciencedirect.=
com/science/article/abs/pii/S0969996114001958</span></a></span><span style=
=3D"font-size:1.5rem;">=C2=A0</span></p></li><li class=3D"listItem ultext">=
<p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-bre=
ak:break-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D=
"https://link.mail.beehiiv.com/v1/c/izQHn03pIPCUBzNloRJcRkq8aLUd2tjJj9v2wgU=
vwKjv1QmIRH%2BfqrefZB1m%0Arm5CLzQxogWua8h0u5O%2BTICVAZNF783dmFRtdEi8%2Fl8Xy=
hrhDaFucVAkyecU%0AdNgFu%2FDD0%2F0O3SHrg8T0Q3iKTqLsajyCskQ16KFo9Z00klS9JtM%3=
D%0A/a68aecfabb2cff2c" target=3D"_blank" rel=3D"noopener noreferrer nofollo=
w"><span>https://pubmed.ncbi.nlm.nih.gov/25046994/</span></a></span><span s=
tyle=3D"font-size:1.5rem;">=C2=A0</span></p></li><li class=3D"listItem ulte=
xt"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word=
-break:break-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" hre=
f=3D"https://link.mail.beehiiv.com/v1/c/enQaOMXSFbodtXpxyNw%2FHdaV8w4jOPgpX=
x1HmdsVuoFm2YAKUSgUXnSHWTVF%0Agf7NaORT6%2Bkf5sLjoWCQqGMyFAO3pVN2jTw3Tscb%2F=
8nqYL6TTJsbu7wGDpvp%0AUBnekDW2b%2FlbAIX8cw%2BUhLutbauqQK3HbJ75co6ixh1ZfG0sM=
Hs%3D%0A/a7f71c8387ad87d6" target=3D"_blank" rel=3D"noopener noreferrer nof=
ollow"><span>https://pmc.ncbi.nlm.nih.gov/articles/PMC5488423/</span></a></=
span><span style=3D"font-size:1.5rem;">=C2=A0</span></p></li><li class=3D"l=
istItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-ali=
gn:left;word-break:break-word;"><span style=3D"font-size:1.5rem;"><a class=
=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/wQ%2B79Y7MGVrnaffr3gYP=
%2B9d1yhpXwLFxln1OfQa%2FyVBMPprBegZkGPiu68rT%0ANi4LCqwzvFrAoDiDDTIUD6ADXwa5=
eznoKg8nBPSEWDvHnGM%2Bfe%2BVw64GhR0p%0AIXWEPndRQ1MAPCXe0wYT%2BgjApk8msT9Neg=
cuor7cqRkugBxgi20%3D%0A/60efa506f6f822ec" target=3D"_blank" rel=3D"noopener=
 noreferrer nofollow"><span>https://www.nature.com/articles/srep45561</span=
></a></span><span style=3D"font-size:1.5rem;">=C2=A0</span></p></li><li cla=
ss=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;t=
ext-align:left;word-break:break-word;"><span style=3D"font-size:1.5rem;"><a=
 class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/PB4QrGrCeWAgU5kS=
nwAMl%2Fqhqfq8Pvzc%2Fussa8Q6T1tf8qe%2FIEkYaXn3g2lU%0AsLUe2d%2BHCvxy1mEjgfql=
5wNg4oCUldgfRupJMKD3Lqon4QmVEICAG%2B2fXdbH%0AMPtid3kb8Z57e58z1hMl9eQX6n6nz%=
2BW6D2WO70xULFdS%2BGhOlJY%3D%0A/562397dfc8ae8bef" target=3D"_blank" rel=3D"=
noopener noreferrer nofollow"><span>https://pubmed.ncbi.nlm.nih.gov/2470282=
1/</span></a></span><span style=3D"font-size:1.5rem;">=C2=A0</span></p></li=
><li class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;paddi=
ng:0px;text-align:left;word-break:break-word;"><span style=3D"font-size:1.5=
rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/lYDJW%2B=
A9G4pXFhHyybQBXw7VeGCRHqVBXc00DKeYW34ygh0ylmboeMcv2gQ4%0APZubPb%2Fn6jNEY4g4=
d9nDF%2F43CrwE4rvQ37S6wb9A1x3hA%2BIXvKcCldCYuZrZ%0AFV%2FeTtKc92khfG3JbikEIT=
lx%2B1WSBLKDDjXL2RbTpiS6r9OyMPs%3D%0A/701c3fd40ab3b87f" target=3D"_blank" r=
el=3D"noopener noreferrer nofollow"><span>https://pmc.ncbi.nlm.nih.gov/arti=
cles/PMC8385525/</span></a></span><span style=3D"font-size:1.5rem;">=C2=A0<=
/span></p></li></ul></div></td></tr></table></td></tr></table></td></tr><tr=
><td align=3D"center" valign=3D"top"><table role=3D"none" width=3D"100%" bo=
rder=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"center"><tr><td><tr=
><td class=3D"b" align=3D"center" valign=3D"top" bgcolor=3D"#FFFFFF" style=
=3D"padding:0px 0px 0px 0px;border-style:solid;border-width: 0px 0px 0px 0p=
x;border-color: #FFFFFF;border-bottom-left-radius:10px;border-bottom-right-=
radius:10px;"><table role=3D"none" width=3D"100%" border=3D"0" cellspacing=
=3D"0" cellpadding=3D"0" align=3D"center"><tr><td align=3D"center" valign=
=3D"top" bgcolor=3D"#030712" style=3D"padding:12px"><table role=3D"none" wi=
dth=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=3D"cent=
er"><tr><td><span style=3D"padding-left:1px;"></span></td><td align=3D"cent=
er" valign=3D"middle" width=3D"75" style=3D"width:75px;"><a href=3D"https:/=
/link.mail.beehiiv.com/v1/c/1fWuWlXg6sOA2YuhbfqXUBmFaamzS5rOSCYT85QSsWbb3VM=
0y9uG0Wp3sbZN%0Ajlm4hTrOlVHiddovz1Nb4dRoP%2FVBEKPhcpu%2FssyZ26EqjZc%2FqQf97=
E5HVXPk%0ASZVAKPK0lS2yRz5K3kbOULiwCzh0NLfqOG1CGeHNlLRo4zpENQw%3D%0A/fd877d4=
97405d33e" style=3D"text-decoration:none;"><img width=3D"22" height=3D"22" =
alt=3D"ig" border=3D"0" style=3D"display:block;max-width:22px;color:light" =
src=3D"https://media.beehiiv.com/cdn-cgi/image/fit=3Dscale-down,format=3Dau=
to,onerror=3Dredirect,quality=3D80/static_assets/instagram_light.png"/></a>=
</td><td align=3D"center" valign=3D"middle" width=3D"75" style=3D"width:75p=
x;"><a href=3D"https://link.mail.beehiiv.com/v1/c/IGqWDHhqpDwJoDmnYsPAbo84R=
Vkn7%2BxIVd%2BQ7FNp8pxzoZDJ2mmVfCx%2FDkrj%0Auzw%2FV%2FWrzLI44EaxO7UBNB6Pwgf=
tLkvz%2BLSLPNZDXnutw0aIUCinYzgxnbKr%0Asu%2F3TKbYlFoDnheNYpWVwiuCK7C5%2FG3Uf=
%2F9l64zrDFEQfUv5O9Y%3D%0A/41006dab11d92fbc" style=3D"text-decoration:none;=
"><img width=3D"22" height=3D"16" alt=3D"yt" border=3D"0" style=3D"display:=
block;max-width:22px;color:light" src=3D"https://media.beehiiv.com/cdn-cgi/=
image/fit=3Dscale-down,format=3Dauto,onerror=3Dredirect,quality=3D80/static=
_assets/youtube_light.png"/></a></td><td><span style=3D"padding-left:1px;">=
</span></td></tr></table></td></tr><tr><td align=3D"center" valign=3D"top" =
style=3D"padding-bottom:20px;padding-left:15px;padding-right:15px;padding-t=
op:20px; " class=3D"dd"><table role=3D"none" border=3D"0" cellspacing=3D"0"=
 cellpadding=3D"0" style=3D"margin:0 auto 0 auto;"><tr><td align=3D"center"=
 valign=3D"top" style=3D"width:189px;"><img src=3D"https://media.beehiiv.co=
m/cdn-cgi/image/fit=3Dscale-down,format=3Dauto,onerror=3Dredirect,quality=
=3D80/uploads/asset/file/77285135-fcd3-48e6-afed-97045dbefd05/beehiiv_profi=
le_photo_large.png?t=3D1744125569" alt=3D"" height=3D"auto" width=3D"189" s=
tyle=3D"display:block;width:100%;border-radius:0px 0px 0px 0px;border-style=
:solid;border-width:0px 0px 0px 0px;box-sizing:border-box;border-color:#E5E=
7EB;" border=3D"0"/></td></tr></table></td></tr><tr><td id=3D"want-more-her=
es-how-you-can-work-wi" class=3D"dd" align=3D"center" valign=3D"top" style=
=3D"color:#2A2A2A;font-weight:normal;padding:0px 15px;text-align:center;"><=
h2 style=3D"color:#2A2A2A;font-weight:normal;mso-line-height-alt:150.0%;"><=
span style=3D"font-size:1.5rem;">Want more? Here=E2=80=99s how you can work=
 with me:</span></h2></td></tr><tr><td id=3D"join-my-private-coaching-group=
-the-" class=3D"dd" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;fo=
nt-weight:normal;padding:0px 15px;text-align:left;"><h4 style=3D"color:#2A2=
A2A;font-weight:normal;mso-line-height-alt:112.5%;"><span style=3D"font-siz=
e:1.5rem;">=F0=9F=91=89Join my private coaching group, The AXION Collective=
:</span></h4></td></tr><tr><td style=3D"padding-bottom:12px;padding-left:37=
px;padding-right:27px;padding-top:12px;" class=3D"ee"><div style=3D"margin-=
left:0px;" class=3D"edm_outlooklist"><ul style=3D"font-weight:normal;list-s=
tyle-type:disc;margin-bottom:12px !important;margin-top:12px !important;pad=
ding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p style=3D"mso-line-h=
eight-alt:150.0%;padding:0px;text-align:left;word-break:break-word;"><span =
style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https://link.mail.bee=
hiiv.com/v1/c/%2FCArrAC235hcQGxiwWceBlO9xqeik8rl9LcvTfquybbpLgfQB5MDVoyeQcD=
g%0AjIeFly91HnonxbWubh0Z7EUEge9r%2FsRH7DsY6P1ffgKSnxE9sR1zb0SRmd%2Fu%0A8IR%=
2FiDjCD08U99rbJZkrfnrnvqevDcFwrWEGxAuJ%2FOBDwPxEZdA%3D%0A/9293bc59ea9afe1e"=
 target=3D"_blank" rel=3D"noopener noreferrer nofollow"><span>The AXION Col=
lective</span></a></span></p></li></ul></div></td></tr><tr><td id=3D"try-ze=
roats-the-worlds-first-sugarf" class=3D"dd" align=3D"left" valign=3D"top" s=
tyle=3D"color:#2A2A2A;font-weight:normal;padding:0px 15px;text-align:left;"=
><h4 style=3D"color:#2A2A2A;font-weight:normal;mso-line-height-alt:112.5%;"=
><span style=3D"font-size:1.5rem;">=F0=9F=91=89Try Zeroats, the world=E2=80=
=99s first sugar-free, naturally flavored oatmeal:</span></h4></td></tr><tr=
><td style=3D"padding-bottom:12px;padding-left:37px;padding-right:27px;padd=
ing-top:12px;" class=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_ou=
tlooklist"><ul style=3D"font-weight:normal;list-style-type:disc;margin-bott=
om:12px !important;margin-top:12px !important;padding:0px 0px 0px 0px;"><li=
 class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0=
px;text-align:left;word-break:break-word;"><span style=3D"font-size:1.5rem;=
">Store:=C2=A0</span><span style=3D"font-size:1.5rem;"><a class=3D"link" hr=
ef=3D"https://link.mail.beehiiv.com/v1/c/4%2BtxRkHf65sUK44Rv8n3xQyzbmwB9yl3=
YVScrVCo%2B7trs7DJNhZy1ASDWGT1%0AHE4CpS15xO26339N7RB8P8qT7AogZo1zGfT0AnXe3g=
Vn1kP9JnkGwsMsGKxB%0AOkWohDVNQ7CJ8BpkfmyWUXf6ztqFKepypHDMWVgA10uRIkGz28g%3D=
%0A/083b9c9f8a803e0d" target=3D"_blank" rel=3D"noopener noreferrer nofollow=
"><span>https://zeroats.com/</span></a></span><span style=3D"font-size:1.5r=
em;">=C2=A0</span></p></li><li class=3D"listItem ultext"><p style=3D"mso-li=
ne-height-alt:150.0%;padding:0px;text-align:left;word-break:break-word;"><s=
pan style=3D"font-size:1.5rem;">Amazon:=C2=A0</span><span style=3D"font-siz=
e:1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/Fbv=
HLMnBNjMw%2FmI%2BCedl0DafjFOOk9qeVg1PBIo4RLDXZAssGZ3KJf%2BBZX37%0Ab8kCb3kDG=
HMvfOtja6DLXYeZDKyS00ow4KUJmPcN3a54s0nU%2FuD1HOGGESN7%0AjMO7ng%2F3dG985tXxr=
%2FdfpRmhNpF95n4JXdsfD1a5pCK4d3CyItQ%3D%0A/89d5ecdd3772f307" target=3D"_bla=
nk" rel=3D"noopener noreferrer nofollow"><span>https://a.co/d/2gq1zJ9</span=
></a></span></p></li></ul></div></td></tr><tr><td id=3D"link-to-all-my-old-=
videos" class=3D"dd" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;f=
ont-weight:normal;padding:0px 15px;text-align:left;"><h4 style=3D"color:#2A=
2A2A;font-weight:normal;mso-line-height-alt:112.5%;"><span style=3D"font-si=
ze:1.5rem;">=F0=9F=91=89</span><span style=3D"font-size:1.5rem;">Link To Al=
l My Old Videos:</span></h4></td></tr><tr><td style=3D"padding-bottom:12px;=
padding-left:37px;padding-right:27px;padding-top:12px;" class=3D"ee"><div s=
tyle=3D"margin-left:0px;" class=3D"edm_outlooklist"><ul style=3D"font-weigh=
t:normal;list-style-type:disc;margin-bottom:12px !important;margin-top:12px=
 !important;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p styl=
e=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-break:brea=
k-word;"><span style=3D"font-size:1.5rem;"><a class=3D"link" href=3D"https:=
//link.mail.beehiiv.com/v1/c/Pi3l9F8kW%2FPkwTOwnt1nXMGhxeou4K549skHG05Mn%2B=
Q8S%2BCnngq%2F5ZXjm0N2%0A95aNXcLDW6Njm1MKhxghQ0AO7kLlV2nwJN0nmlr9EqbmHzRxBC=
VMRrzT2Gwo%0AupH4CFWWqdHzkNlqx6AXTgTzsbOYAWeflLAhaDEanYeOkwJi%2Bs4%3D%0A/63=
473c963d2c467d" target=3D"_blank" rel=3D"noopener noreferrer nofollow"><spa=
n>DropBox with all videos</span></a></span></p></li></ul></div></td></tr><t=
r><td id=3D"link-to-all-my-old-videos" class=3D"dd" align=3D"left" valign=
=3D"top" style=3D"color:#2A2A2A;font-weight:normal;padding:0px 15px;text-al=
ign:left;"><h4 style=3D"color:#2A2A2A;font-weight:normal;mso-line-height-al=
t:112.5%;"><span style=3D"font-size:1.5rem;">=F0=9F=91=89</span><span style=
=3D"font-size:1.5rem;">Audio Versions of All Videos:</span></h4></td></tr><=
tr><td style=3D"padding-bottom:12px;padding-left:37px;padding-right:27px;pa=
dding-top:12px;" class=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_=
outlooklist"><ul style=3D"font-weight:normal;list-style-type:disc;margin-bo=
ttom:12px !important;margin-top:12px !important;padding:0px 0px 0px 0px;"><=
li class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding=
:0px;text-align:left;word-break:break-word;"><span style=3D"font-size:1.5re=
m;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/Sr%2F9GkFA=
zYdyUdgvozNhJ%2FSqS6OaDHSs9iQbuoXqdKHFomqB%2BHbmtdzIm8%2Br%0ALwmlUVxYo9tcBJ=
tjTzS%2BSmZwu0VSZxfdz29FogtHTUdjcTCSbM5EU0b%2B%2BO79%0AfGLbWxhzCXGQ5S%2Fkqb=
u8WvOPzmeLA0HMT%2FxrGS07oqCD4wh7hWU%3D%0A/77e4726babe495c1" target=3D"_blan=
k" rel=3D"noopener noreferrer nofollow"><span>Itunes</span></a></span></p><=
/li><li class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;pa=
dding:0px;text-align:left;word-break:break-word;"><span style=3D"font-size:=
1.5rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/Jw%2F=
7aRIr3oSXEUrQkDJSbXtSs65vLCaq0TdhYjpXGm7iw9OwZz6bjMzQC6%2FG%0AJ5II8T3e5jSE%=
2Ftl5JtrGUdfwGXCagh6TEWS2VA%2By7kZufhJ%2FIlFoR7YLblBl%0AVZZRR7Pg7p9%2F0OVhf=
hPwQHIbl3mzQCUcCdnYhKErTMQitvcwbng%3D%0A/05b2e48189e4629d" target=3D"_blank=
" rel=3D"noopener noreferrer nofollow"><span>Spotify</span></a></span></p><=
/li></ul></div></td></tr><tr><td id=3D"get-the-peptide-cheat-sheet" class=
=3D"dd" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:no=
rmal;padding:0px 15px;text-align:left;"><h3 style=3D"color:#2A2A2A;font-wei=
ght:normal;mso-line-height-alt:125.0%;"><span style=3D"font-size:1.5rem;">=
=F0=9F=91=89Get the Peptide Cheat Sheet:</span></h3></td></tr><tr><td style=
=3D"padding-bottom:12px;padding-left:37px;padding-right:27px;padding-top:12=
px;" class=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_outlooklist"=
><ul style=3D"font-weight:normal;list-style-type:disc;margin-bottom:12px !i=
mportant;margin-top:12px !important;padding:0px 0px 0px 0px;"><li class=3D"=
listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-al=
ign:left;word-break:break-word;"><span style=3D"font-size:1.5rem;"><a class=
=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/QoScS292cR56UePJyHSqwL=
kh9cFUkwo3ee4yBv%2B%2FrOHaOSeh1l2w3tIEVil%2F%0Ar6atyr9a4WZhbwTbFl8LWEgmCzTb=
xC4gZR3O42f3Ce3VogNvMBUitY3tt9%2Fz%0Av3aT9Sxetb7O1Qqg7cfZYR06efwJA0qO2goj3L=
QUR5K5eSmtAcE%3D%0A/a73005cfb2af3734" target=3D"_blank" rel=3D"noopener nor=
eferrer nofollow"><span>Peptide Cheat Sheet</span></a></span></p></li></ul>=
</div></td></tr><tr><td id=3D"all-my-daily-essentials-on-amazon" class=3D"d=
d" align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:normal;=
padding:0px 15px;text-align:left;"><h3 style=3D"color:#2A2A2A;font-weight:n=
ormal;mso-line-height-alt:125.0%;"><span style=3D"font-size:1.5rem;">=F0=9F=
=91=89All my daily essentials on Amazon</span></h3></td></tr><tr><td style=
=3D"padding-bottom:12px;padding-left:37px;padding-right:27px;padding-top:12=
px;" class=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_outlooklist"=
><ul style=3D"font-weight:normal;list-style-type:disc;margin-bottom:12px !i=
mportant;margin-top:12px !important;padding:0px 0px 0px 0px;"><li class=3D"=
listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-al=
ign:left;word-break:break-word;"><span style=3D"font-size:1.5rem;"><a class=
=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/MxoAj1bT%2BNwzlQfwoYoL=
jDCvwQuWGC1LeX7iJriHx0%2FG2JV3MfUg2ma80W6K%0AiheM%2B040MhR43HfHLTbTHTeY6Hwu=
ACUhAoCNoen61O2G0wvXnQWN33fEVfrh%0A0MYkPkJvE9dJF2hW4WhbcutWPS7YhLMA2H9bDVyk=
h3CTviUP6sU%3D%0A/db0c9969cedb6847" target=3D"_blank" rel=3D"noopener noref=
errer nofollow"><span>Amazon Storefront</span></a></span></p></li></ul></di=
v></td></tr><tr><td id=3D"get-discounts-on-your-favorite-pept" class=3D"dd"=
 align=3D"left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:normal;pa=
dding:0px 15px;text-align:left;"><h3 style=3D"color:#2A2A2A;font-weight:nor=
mal;mso-line-height-alt:125.0%;"><span style=3D"font-size:1.5rem;">=F0=9F=
=91=89Get discounts on your favorite peptides and research chemicals:</span=
></h3></td></tr><tr><td style=3D"padding-bottom:12px;padding-left:37px;padd=
ing-right:27px;padding-top:12px;" class=3D"ee"><div style=3D"margin-left:0p=
x;" class=3D"edm_outlooklist"><ul style=3D"font-weight:normal;list-style-ty=
pe:disc;margin-bottom:12px !important;margin-top:12px !important;padding:0p=
x 0px 0px 0px;"><li class=3D"listItem ultext"><p style=3D"mso-line-height-a=
lt:150.0%;padding:0px;text-align:left;word-break:break-word;"><span style=
=3D"color:#ff0000;font-family:Verdana,Geneva,sans-serif;font-size:1.5rem;fo=
nt-weight:700;">PEPTIDES</span></p><ul style=3D"list-style-type:disc;margin=
:0px 0px;padding:0px 0px 0px 0px;"><li class=3D"listItem ultext"><p style=
=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;word-break:break=
-word;"><span style=3D"font-size:1.5rem;">BioLongevity Labs (use code hunte=
rw for 15% off):=C2=A0</span><span style=3D"font-size:1.5rem;"><a class=3D"=
link" href=3D"https://link.mail.beehiiv.com/v1/c/DjoWR3JIRPUJY5pym8cF2Ottnm=
yNGmbPeAWuDfWsxJ1ttAkmhhjcKyHebC7U%0AOeSJNSbM3SmyA6bYocxIuZi8bqOpjwPZxSUIA5=
YeIRG2shA5S%2BERK4G1l30V%0A4CveMpoTexge43xAFdE5Z60kiprW5AsPZiB4gihJHRy2hQ4N=
kGI%3D%0A/ef4e32d2fa4e1e58" target=3D"_blank" rel=3D"noopener noreferrer no=
follow"><span>https://biolongevitylabs.com/</span></a></span><span style=3D=
"font-size:1.5rem;">=C2=A0</span></p></li></ul></li><li class=3D"listItem u=
ltext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-align:left;w=
ord-break:break-word;"><span style=3D"color:#ff0000;font-family:Verdana,Gen=
eva,sans-serif;font-size:1.5rem;font-weight:700;">ANCILLARIES</span></p><ul=
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px;text-align:left;word-break:break-word;"><span style=3D"font-size:1.5rem;=
">Anabolic Pharmacist (Genotropin, Jardiance, Modafinil and more =E2=80=94 =
use code hunter10 for 10% off): </span><span style=3D"font-size:1.5rem;"><b=
><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/kx1Nhl%2FoCq9=
WG6ixAgPFW2W0zfdq6w6H8KqkdWSTLIRuKzvJyTiI5Pt6crot%0AeZY7qDKXqzJoTdZfM2MzzwN=
6OmYU%2BxLLbtG8JodPciLV70CowOKbpfZc3DAY%0ARjjkhSo6HBXj8sz3XpHlmPAea0UmDxfPG=
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=3D"10-off-my-favorite-protein-powder-a" class=3D"dd" align=3D"left" valign=
=3D"top" style=3D"color:#2A2A2A;font-weight:normal;padding:0px 15px;text-al=
ign:left;"><h3 style=3D"color:#2A2A2A;font-weight:normal;mso-line-height-al=
t:125.0%;"><span style=3D"font-size:1.5rem;">=F0=9F=91=8910% off the BEST w=
orkout supplements from Unmatched Supps (pre-workout, whey protein, creatin=
e, EAAs, electrolytes - use code HUNTERW at checkout):</span></h3></td></tr=
><tr><td style=3D"padding-bottom:12px;padding-left:37px;padding-right:27px;=
padding-top:12px;" class=3D"ee"><div style=3D"margin-left:0px;" class=3D"ed=
m_outlooklist"><ul style=3D"font-weight:normal;list-style-type:disc;margin-=
bottom:12px !important;margin-top:12px !important;padding:0px 0px 0px 0px;"=
><li class=3D"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;paddi=
ng:0px;text-align:left;word-break:break-word;"><span style=3D"font-size:1.5=
rem;"><a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/S8pTGW37=
nia3m%2Bjcqk9fblrCvuKfQFjILdwwE3MXRJdw2%2B91i9WnYNXwMT%2B5%0ADhiOp7%2B5Q1NR=
g4UwK3CxYkL4bFZ1lRVKWwxB0qKm2ouiMP5DCYz8PYmpb2Pt%0ACMkQF8qmlDKoFNQEWxVYJhDs=
Y5AtIuaA7NoxlRCdsOZHre8dUj8%3D%0A/b4ba484baf294e0a" target=3D"_blank" rel=
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r><tr><td id=3D"submit-a-video-topic-for-my-next-yo" class=3D"dd" align=3D"=
left" valign=3D"top" style=3D"color:#2A2A2A;font-weight:normal;padding:0px =
15px;text-align:left;"><h3 style=3D"color:#2A2A2A;font-weight:normal;mso-li=
ne-height-alt:125.0%;"><span style=3D"font-size:1.5rem;">=F0=9F=91=89Submit=
 A Video Topic For My Next YouTube Video:</span></h3></td></tr><tr><td styl=
e=3D"padding-bottom:12px;padding-left:37px;padding-right:27px;padding-top:1=
2px;" class=3D"ee"><div style=3D"margin-left:0px;" class=3D"edm_outlooklist=
"><ul style=3D"font-weight:normal;list-style-type:disc;margin-bottom:12px !=
important;margin-top:12px !important;padding:0px 0px 0px 0px;"><li class=3D=
"listItem ultext"><p style=3D"mso-line-height-alt:150.0%;padding:0px;text-a=
lign:left;word-break:break-word;"><span style=3D"font-size:1.5rem;"><a clas=
s=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/6O0PjqmL9oaEnrRHQSCog=
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wgdutd1%2F6%2BguHgUCAoTRzhrqJWUkqpj25%0AhWKZeHkAsRSxY7ZgqxyUwHOCfMM2VaYSZda=
nbGDvUAIlz831saY%3D%0A/0a4f7615cf7da827" target=3D"_blank" rel=3D"noopener =
noreferrer nofollow"><span>https://hunterwilliamsvideotopic.carrd.co/</span=
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er" valign=3D"top" style=3D"padding:15px 15px 15px 15px;"><table role=3D"no=
ne" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" align=
=3D"center"><tr><td align=3D"center" valign=3D"top"><p style=3D"font-family=
:'Verdana',Geneva,sans-serif;color:#2D2D2D!important;"> Update your email p=
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le=3D"text-decoration:underline;text-decoration-color:#2D2D2D!important;col=
or:#2D2D2D!important;"> here</a></p><p class=3D"copyright" style=3D"font-fa=
mily:'Verdana',Geneva,sans-serif;color:#2D2D2D!important;"> &copy; 2026 Hun=
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=3D"display:table-cell !important;"><table role=3D"none" border=3D"0" cells=
pacing=3D"0" cellpadding=3D"0" align=3D"center" style=3D"display:table !imp=
ortant;"><tr style=3D"display:table-row !important;"><td class=3D"u" align=
=3D"center" valign=3D"middle" height=3D"32" style=3D"height:32px;display:ta=
ble-cell !important; max-height: 32px !important;margin:0px !important; bac=
kground-color: #ffffff !important;"><a style=3D"line-height:32px !important=
;text-decoration:none;display:block !important;" href=3D"https://link.mail.=
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